5-Bromo-thiophene-2-carboxylic acid methyl ester

Product Name: 5-Bromo-thiophene-2-carboxylic acid methyl ester
CAS No.: 62224-19-5
Chemical Name: 5-Bromo-thiophene-2-carboxylic acid methyl ester
Synonyms: 5-broMo-;Methyl 2-broMothiophene-5...;2-Bromo-5-(methoxycarbonyl)thiophene;Methyl 2-broMothiophene-5-carboxylate;Methyl 5-bromo-2-thiophenecarboxylate;methyl 5-bromothiophene-2-carboxylate;5-bromo-2-thiophenecarboxylic acid methyl ester;5-Bromo-thiophene-2-carboxylic acid methyl ester;2-Thiophenecarboxylic acid, 5-bromo-, methyl ester
CBNumber: CB01113336
Molecular Formula: C6H5BrO2S
Formula Weight: 221.07
MOL File: 62224-19-5.mol

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5-Bromo-thiophene-2-carboxylic acid methyl ester Property

Melting point:: 87-88℃
Boiling point:: 251.9±20.0 °C(Predicted)
Density: 1.662±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C6H5BrO2S/c1-9-6(8)4-2-3-5(7)10-4/h2-3H,1H3
InChIKey: QLWUHAQCKDHUNL-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)SC(Br)=CC=1

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B6245
Product name: Methyl 5-Bromothiophene-2-carboxylate
Purity: min. 98.0 %
Packaging: 5G
Price: $155
Updated: 2025/07/31

TCI Chemical

Product number: B6245
Product name: Methyl 5-Bromothiophene-2-carboxylate
Purity: min. 98.0 %
Packaging: 25G
Price: $470
Updated: 2025/07/31

TRC

Product number: M294170
Product name: Methyl5-Bromo-2-thiophenecarboxylate
Packaging: 1g
Price: $85
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6H66-9-11
Product name: Methyl 5-bromothiophene-2-carboxylate
Purity: 97.0%
Packaging: 250mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-B0140
Product name: 2-Thiophenecarboxylicacid,5-bromo-,methylester
Purity: >97.0%
Packaging: 10g
Price: $94
Updated: 2021/12/16

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5-Bromo-thiophene-2-carboxylic acid methyl ester Chemical Properties,Usage,Production

Uses

Methyl 5-Bromo-2-thiophenecarboxylate is used as a reagent in the synthesis of trisubstituted isoxazole derivatives which are novel nonsteroidal antagonists of Farnesoid X Receptor (FXR). FXR plays an important role in regulation of cholesterol, lipid and glucose metabolism.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 35, p. 1109, 1992 DOI: 10.1021/jm00084a016

Synthesis

67-56-1

7311-63-9

62224-19-5

General procedure for the synthesis of methyl 5-bromothiophene-2-carboxylate from methanol and 5-bromo-2-carboxythiophene: 950 mg (4.62 mmol) of 5-bromo-2-carboxythiophene was accurately weighed and dissolved in 10 mL of methanol. Under stirring conditions, 2 ml of sulfoxide chloride (SOCl2) was slowly added dropwise to the solution. After completion of the reaction, the reaction mixture was cooled to room temperature. Subsequently, the solvent was removed by evaporation under reduced pressure. The residue was dissolved in an appropriate amount of toluene and dried by evaporation under reduced pressure, this process was repeated three times to completely remove the residual sulfoxide chloride and methanol. The intermediate 5-bromothiophene-2-carboxylic acid methyl ester was finally obtained as 1.0 g in 100% yield.

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 6, p. 1109 - 1116
[2] Patent: CN103992311, 2017, B. Location in patent: Paragraph 0103; 0114; 0115; 0116
[3] Angewandte Chemie - International Edition, 2010, vol. 49, # 38, p. 6817 - 6820
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 9562 - 9575
[5] Journal of Materials Chemistry A, 2013, vol. 1, # 34, p. 10008 - 10015

5-Bromo-thiophene-2-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-thiophene-2-carboxylic acid methyl ester Suppliers

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View Lastest Price from 5-Bromo-thiophene-2-carboxylic acid methyl ester manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Bromo-thiophene-2-carboxylic acid methyl ester 62224-19-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Bromo-thiophene-2-carboxylic acid methyl ester 62224-19-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 5-Bromo-thiophene-2-carboxylic acid methyl ester 62224-19-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-25

62224-19-5, 5-Bromo-thiophene-2-carboxylic acid methyl esterRelated Search:

Dibenzothiophene 2-Thiophenecarboxylic acid, 5-bromo-4-fluoro-, methyl ester 2-Thiophenecarboxylic acid, 4,5-dibromo-3-fluoro-, methyl ester METHYL 4,5-DIBROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE RARECHEM AL BI 0455 SPECS AI-942/25034100 METHYL 5-BROMO-3-METHYLTHIOPHENE-2-CARBOXYLATE METHYL 4,5-DIBROMO-3-METHOXYTHIOPHENE-2-CARBOXYLATE Ethyl 5-bromothiophene-2-carboxylate methyl 5-bromo-4-(chlorosulfonyl)thiophene-2-carboxylate METHYL 5-BROMO-4-METHYL-2-THIOPHENECARBOXYLATE 5-Bromo-4-nitrothiophene-2-carboxylic acid methyl ester 5-Bromo-thiophene-2-carboxylic acid methyl ester METHYL4,5-DIBROMOTHIOPHENE-2-CARBOXYLATE METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97

5-Bromo-thiophene-2-carboxylic acid methyl ester

Methyl 5-bromo-2-thiophenecarboxylate

5-broMo-

Methyl 2-broMothiophene-5...

Methyl 2-broMothiophene-5-carboxylate

2-Thiophenecarboxylic acid, 5-bromo-, methyl ester

methyl 5-bromothiophene-2-carboxylate

5-bromo-2-thiophenecarboxylic acid methyl ester

2-Bromo-5-(methoxycarbonyl)thiophene

62224-19-5

API intermediates