ChemicalBook > CAS DataBase List > 6-Chloro-imidazo[1,2-a]pyrazine

6-Chloro-imidazo[1,2-a]pyrazine

Uses

Product Name: 6-Chloro-imidazo[1,2-a]pyrazine
CAS No.: 76537-23-0
Chemical Name: 6-Chloro-imidazo[1,2-a]pyrazine
Synonyms: 6-Chloro-imidazo[1,2-a]pyrazine;Imidazo[1,2-a]pyrazine, 6-chloro-
CBNumber: CB01113381
Molecular Formula: C6H4ClN3
Formula Weight: 153.57
MOL File: 76537-23-0.mol

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6-Chloro-imidazo[1,2-a]pyrazine Property

Melting point:: 137-138℃
Density: 1.51
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.68±0.30(Predicted)
Appearance: Light yellow to brown Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C381690
Product name: 6-Chloroimidazo[1,2-a]pyrazine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: C12875
Product name: 6-Chloroimidazo[1,2-a]pyrazine
Purity: 95%
Packaging: 1g
Price: $40
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-J0
Product name: 6-Chloroimidazo[1,2-a]pyrazine
Packaging: 250mg
Price: $48
Updated: 2021/12/16

AK Scientific

Product number: W8334
Product name: 6-Chloroimidazo[1,2-a]pyrazine
Packaging: 1g
Price: $74
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: C12875
Product name: 6-Chloroimidazo[1,2-a]pyrazine
Purity: 95%
Packaging: 5g
Price: $120
Updated: 2021/12/16

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6-Chloro-imidazo[1,2-a]pyrazine Chemical Properties,Usage,Production

Uses

6-Chloroimidazole[1,2A]pyrazine is a heterocyclic derivative that can be used as a pharmaceutical intermediate.

Synthesis

33332-29-5

2032-35-1

76537-23-0

2-Amino-5-chloropyrazine (2.6 g, 20 mmol) and 2-bromo-1,1-diethoxyethane (12.0 g, 60.89 mmol) were used as starting materials and dissolved in 30 mL of isopropanol. Subsequently, hydrogen bromide solution (10.5 g, 62.22 mmol) was added to the reaction system and the reaction was stirred at 80°C overnight. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with sodium bicarbonate to 8. Next, extraction was carried out with dichloromethane, the organic phases were separated and combined, and the crude product was concentrated under reduced pressure. Purification by Combi-flash fast column chromatography (eluent ratio: dichloromethane:methanol = 90:10:70:30) afforded a brown solid product, 6-chloroimidazo[1,2A]pyrazine (2.3 g), in a yield of 49.75% and a purity of 96.63%. The product did not need further purification and could be used directly in the subsequent reaction.

References

[1] Patent: CN105524068, 2016, A. Location in patent: Paragraph 0286; 0287
[2] Journal of Medicinal Chemistry, 1983, vol. 26, # 3, p. 357 - 363

6-Chloro-imidazo[1,2-a]pyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Chloro-imidazo[1,2-a]pyrazine manufacturers

Shanghai Rlavie Technology Co ltd

Product: 6-Chloro-imidazo[1,2-a]pyrazine 76537-23-0
Price: US $0.00-0.00/kg
Min. Order: 0.0001kg
Purity: 98%minNMR
Supply Ability: 50kg/month
Release date: 2022-05-10

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76537-23-0