5-Trifluoromethyl-1-tetralone

Product Name: 5-Trifluoromethyl-1-tetralone
CAS No.: 885268-02-0
Chemical Name: 5-Trifluoromethyl-1-tetralone
Synonyms: 5-(trifluoroMethyl)-3,4-dihydro-2H-naphthalen-1-one;5-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one;1(2H)-Naphthalenone, 3,4-dihydro-5-(trifluoromethyl)-
CBNumber: CB01116852
Molecular Formula: C11H9F3O
Formula Weight: 214.18
MOL File: 885268-02-0.mol

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5-Trifluoromethyl-1-tetralone Property

Boiling point:: 257.6±40.0 °C(Predicted)
Density: 1.288±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: Colorless to light yellow Liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0295517
Product name: 5-TRIFLUOROMETHYL-1-TETRALONE
Purity: 98.00%
Packaging: 5MG
Price: $500.18
Updated: 2021/12/16

Chemenu

Product number: CM243082
Product name: 5-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one
Purity: 95%
Packaging: 1g
Price: $795
Updated: 2021/12/16

Crysdot

Product number: CD12017489
Product name: 5-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one
Purity: 95+%
Packaging: 1g
Price: $842
Updated: 2021/12/16

Alichem

Product number: 885268020
Product name: 5-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one
Packaging: 1g
Price: $858.5
Updated: 2021/12/16

Alichem

Product number: 885268020
Product name: 5-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one
Packaging: 100mg
Price: $221.52
Updated: 2021/12/16

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5-Trifluoromethyl-1-tetralone Chemical Properties,Usage,Production

Synthesis

899350-21-1

885268-02-0

General procedure for the synthesis of 5-(trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one from 4-(2-(trifluoromethyl)phenyl)butyric acid: 4-(2-(trifluoromethyl)phenyl)butyric acid (246 mg, 1.06 mmol) was dissolved in chlorosulphonic acid (2 mL) at 0 °C, and the reaction mixture was kept stirred for 1 hour at 0 °C. Upon completion of the reaction, the reaction solution was slowly poured into ice water to quench the reaction. The organic phase was extracted with ethyl acetate, and the organic layer was washed sequentially with saturated aqueous sodium bicarbonate solution and saturated sodium chloride solution, then dried with anhydrous magnesium sulfate and filtered. The solvent was removed by distillation under reduced pressure to afford the target compound 5-(trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one as a colorless oil (160 mg, 70% yield).1H NMR (CDCl3, 500 MHz) data were as follows: δ 2.16-2.21 (2H, m), 2.70 (2H, dd, J = 6.4, 6.8 Hz), 3.14 (2H, t, J = 6.4 Hz), 7.43 (1H, t, J = 7.8 Hz), 7.83 (1H, d, J = 7.8 Hz), 8.27 (1H, d, J = 7.8 Hz).

References

[1] Patent: US2011/53974, 2011, A1. Location in patent: Page/Page column 57-58

5-Trifluoromethyl-1-tetralone Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Trifluoromethyl-1-tetralone Suppliers

China 20 India 1 United States 3 Global 24

Shanghai Hanhong Scientific Co.,Ltd.

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Shanghai Kaiwei Chemical Technology Co., Ltd.

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Taizhou Nanfeng Pharmaceutical Research Institute

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885268-02-0, 5-Trifluoromethyl-1-tetraloneRelated Search:

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5-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one

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1(2H)-Naphthalenone, 3,4-dihydro-5-(trifluoromethyl)-

885268-02-0