5-Trifluoromethyl-1-tetralone
- Product Name
- 5-Trifluoromethyl-1-tetralone
- CAS No.
- 885268-02-0
- Chemical Name
- 5-Trifluoromethyl-1-tetralone
- Synonyms
- 5-(trifluoroMethyl)-3,4-dihydro-2H-naphthalen-1-one;5-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one;1(2H)-Naphthalenone, 3,4-dihydro-5-(trifluoromethyl)-
- CBNumber
- CB01116852
- Molecular Formula
- C11H9F3O
- Formula Weight
- 214.18
- MOL File
- 885268-02-0.mol
5-Trifluoromethyl-1-tetralone Property
- Boiling point:
- 257.6±40.0 °C(Predicted)
- Density
- 1.288±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0295517
- Product name
- 5-TRIFLUOROMETHYL-1-TETRALONE
- Purity
- 98.00%
- Packaging
- 5MG
- Price
- $500.18
- Updated
- 2021/12/16
- Product number
- 885268020
- Product name
- 5-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one
- Packaging
- 100mg
- Price
- $221.52
- Updated
- 2021/12/16
- Product number
- CD12017489
- Product name
- 5-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $337
- Updated
- 2021/12/16
- Product number
- 885268020
- Product name
- 5-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one
- Packaging
- 250mg
- Price
- $353.6
- Updated
- 2021/12/16
- Product number
- CM243082
- Product name
- 5-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $795
- Updated
- 2021/12/16
5-Trifluoromethyl-1-tetralone Chemical Properties,Usage,Production
Synthesis
899350-21-1
885268-02-0
General procedure for the synthesis of 5-(trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one from 4-(2-(trifluoromethyl)phenyl)butyric acid: 4-(2-(trifluoromethyl)phenyl)butyric acid (246 mg, 1.06 mmol) was dissolved in chlorosulphonic acid (2 mL) at 0 °C, and the reaction mixture was kept stirred for 1 hour at 0 °C. Upon completion of the reaction, the reaction solution was slowly poured into ice water to quench the reaction. The organic phase was extracted with ethyl acetate, and the organic layer was washed sequentially with saturated aqueous sodium bicarbonate solution and saturated sodium chloride solution, then dried with anhydrous magnesium sulfate and filtered. The solvent was removed by distillation under reduced pressure to afford the target compound 5-(trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one as a colorless oil (160 mg, 70% yield).1H NMR (CDCl3, 500 MHz) data were as follows: δ 2.16-2.21 (2H, m), 2.70 (2H, dd, J = 6.4, 6.8 Hz), 3.14 (2H, t, J = 6.4 Hz), 7.43 (1H, t, J = 7.8 Hz), 7.83 (1H, d, J = 7.8 Hz), 8.27 (1H, d, J = 7.8 Hz).
References
[1] Patent: US2011/53974, 2011, A1. Location in patent: Page/Page column 57-58
5-Trifluoromethyl-1-tetralone Preparation Products And Raw materials
Raw materials
Preparation Products
5-Trifluoromethyl-1-tetralone Suppliers
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- Country
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