6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE

Product Name: 6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE
CAS No.: 21594-52-5
Chemical Name: 6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE
Synonyms: 6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one;Oxazolo[4,5-b]pyridin-2(3H)-one,6-broMo-;6-Bromo[1,3]oxazolo[4,5-b]pyridin-2(3H)-one;6-bromo-3H-[1,3]oxazolo[4,5-b]pyridin-2-one;6-broMo-2H,3H-[1,3]oxazolo[4,5-b]pyridin-2-one;6-Bromo[1,3]oxazolo[4,5-b]pyridin-2(3H)-one, 97%;6- broMo -3H- oxazole and [4,5-B] pyridine -2- ketone;6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE ISO 9001：2015 REACH
CBNumber: CB01118553
Molecular Formula: C6H3BrN2O2
Formula Weight: 215
MOL File: 21594-52-5.mol

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6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE Property

Melting point:: 233-235 °C
Boiling point:: 219.7±50.0 °C(Predicted)
Density: 2.19±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: Liquid
pka: 1.32±0.20(Predicted)
color: Clear colorless to amber
InChI: InChI=1S/C6H3BrN2O2/c7-3-1-4-5(8-2-3)9-6(10)11-4/h1-2H,(H,8,9,10)
InChIKey: VQPBRWIFFBIRRP-UHFFFAOYSA-N
SMILES: C12NC(=O)OC1=CC(Br)=CN=2

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Safety

HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B688768
Product name: 6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB32835
Product name: 6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one
Packaging: 500mg
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: W4484
Product name: 6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one
Packaging: 10g
Price: $105
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB32835
Product name: 6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one
Packaging: 1g
Price: $168
Updated: 2021/12/16

AK Scientific

Product number: W4484
Product name: 6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one
Packaging: 25g
Price: $201
Updated: 2021/12/16

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6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE Chemical Properties,Usage,Production

Synthesis

60832-72-6

21594-52-5

General procedure for the synthesis of 6-bromo-3H-oxazolo[4,5-b]pyridin-2-one from 2,3-dihydropyrido[2,3-d][1,3]oxazol-2-one: In a dry 3000 mL single-necked round-bottomed flask, 1500 mL of acetonitrile and 360 mL of acetic acid were sequentially added, followed by 42.8 g of 2,3-dihydropyrido[2,3-d][1,3 ]oxazol-2-one. After the ingredients were completely dissolved, 64.2 g of N-bromosuccinimide (NBS) was added in batches and the reaction mixture was stirred at room temperature for 14 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and gas chromatography (GC), and after confirming the completion of the reaction, 20 mL of sodium persulfate (24 g) was added. At the end of the reaction, the solvent was removed by rotary evaporator and 300 mL of water was added to the residue and extracted twice with 300 mL of ether. The organic phases were combined and washed sequentially with 180 mL of 2 N sodium hydroxide solution and 300 mL of saturated saline. The organic phase was dried with anhydrous sodium sulfate overnight. The drier was removed by filtration and the filtrate was concentrated under reduced pressure to give 64.1 g of the crude product 6-bromo-3H-oxazolo[4,5-b]pyridin-2-one. The crude product was recrystallized by mixed solvent recrystallization of dichloromethane and ethyl acetate to give 59.9 g of pure product in 89% yield and 98% purity (GC assay). The melting point of the product was measured to be 231°C to 234°C (literature value: 232°C to 233°C).

References

[1] Patent: CN103709174, 2016, B. Location in patent: Paragraph 0021-0022
[2] Patent: WO2009/100536, 2009, A1. Location in patent: Page/Page column 95-96
[3] Patent: WO2010/96389, 2010, A1. Location in patent: Page/Page column 42; 44
[4] Patent: WO2010/135014, 2010, A1. Location in patent: Page/Page column 50-51
[5] Journal of Medicinal Chemistry, 1993, vol. 36, # 4, p. 497 - 503

6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE Suppliers

China 131 Germany 1 India 3 United Kingdom 2 United States 8 Global 145

LinkChem Technology Co., Ltd.

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View Lastest Price from 6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE manufacturers

Dideu Industries Group Limited

Product: 6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE 21594-52-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one 21594-52-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one 21594-52-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

21594-52-5, 6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE Related Search:

metamifop 5-BROMO-3-METHOXYPYRIDIN-2-AMINE 3-Bromo-5-methylpyridine 6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one 2-amino-5-bromopyridin-3-ol

6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one

6-Bromo[1,3]oxazolo[4,5-b]pyridin-2(3H)-one, 97%

6-broMo-2H,3H-[1,3]oxazolo[4,5-b]pyridin-2-one

Oxazolo[4,5-b]pyridin-2(3H)-one,6-broMo-

6- broMo -3H- oxazole and [4,5-B] pyridine -2- ketone

6-bromo-3H-[1,3]oxazolo[4,5-b]pyridin-2-one

6-BROMO-3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE ISO 9001：2015 REACH

6-Bromo[1,3]oxazolo[4,5-b]pyridin-2(3H)-one

21594-52-5

C6H3BrN2O2

Heterocycles series