2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one

Product Name: 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
CAS No.: 60832-72-6
Chemical Name: 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
Synonyms: Oxazolophridinon;2,3-Dihydropyrido[2;Oxazolo[4,5-b]pyridin-2-ol;Crizotinib Intermediates 3;3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE;[1,3]Oxazolo[4,5-b]pyridin-2-ol;Oxazolo[4,5-b]pyridine-2(3H)one;oxazolo[4,5-b]pyridin-2(3H)-one;oxazolo[4,5-6]pyridine-2(3h)-one;3H-Oxazolo[4,5-b]pyridin-2(3H)-one
CBNumber: CB0114606
Molecular Formula: C6H4N2O2
Formula Weight: 136.11
MOL File: 60832-72-6.mol

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2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Property

Melting point:: 214 °C
Boiling point:: 253.8±23.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO, Methanol
pka: 2.76±0.20(Predicted)
form: Solid
color: Tan
InChI: InChI=1S/C6H4N2O2/c9-6-8-5-4(10-6)2-1-3-7-5/h1-3H,(H,7,8,9)
InChIKey: OVLXOTUWFLHWQT-UHFFFAOYSA-N
SMILES: C12NC(=O)OC1=CC=CN=2
CAS DataBase Reference: 60832-72-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38-36-22
Safety Statements: 22-26-36/37/39
Hazard Note: Harmful
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS005683
Product name: 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
Purity: AldrichCPR
Packaging: 100MG
Price: $68.1
Updated: 2023/01/07

TCI Chemical

Product number: O0408
Product name: Oxazolo[4,5-b]pyridin-2(3H)-one
Packaging: 5G
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: O0408
Product name: Oxazolo[4,5-b]pyridin-2(3H)-one
Packaging: 25G
Price: $184
Updated: 2025/07/31

TRC

Product number: D449430
Product name: 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
Packaging: 50g
Price: $950
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0019385
Product name: 2,3-DIHYDROPYRIDO[2,3-D][1,3]OXAZOL-2-ONE
Purity: 95.00%
Packaging: 2.5G
Price: $958.94
Updated: 2021/12/16

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2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one is a benzoxazolone analogue that may be used to inhibit the nitric oxide synthases (NOS).

Definition

ChEBI: Oxazolo[4,5-b]pyridin-2(3H)-one is a lactone. It derives from a hydride of an oxazolo[4,5-b]pyridine.

Synthesis

16867-03-1

530-62-1

60832-72-6

N,N'-Carbonyldiimidazole (57.4 g, 354.2 mmol) was slowly added to a tetrahydrofuran (THF) solution (400 mL) of 2-amino-3-hydroxypyridine (26.0 g, 236.1 mmol, purchased from Aldrich) as described in Step 4-i of Scheme 4. The resulting reaction mixture was stirred at 70 °C for 14 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The concentrated residue was dissolved in dichloromethane (DCM) (500 mL) and subsequently washed with 2N sodium hydroxide (NaOH) solution (3 x 100 mL). The aqueous phases were combined, cooled to 0 °C, and the pH was adjusted to 6 with 6 N hydrochloric acid (HCl).At this point, the product precipitated as a precipitate, which was collected through a sintered funnel and washed with cold water (100 mL). Finally, the product was dried under vacuum to afford 2,3-dihydropyrido[2,3-d][1,3]oxazol-2-one (compound 1011, 26.0 g, 81% yield). The product was characterized by the following data: electrospray mass spectrometry (ESMS) (M + H) + m/z 137; 1H NMR (DMSO-d6) δ 12.4 (br, 1H), 8.0 (d, 1H), 7.6 (d, 1H), 7.1 (dd, 1H).

References

[1] Patent: WO2007/67416, 2007, A2. Location in patent: Page/Page column 56; 91
[2] Patent: WO2010/96389, 2010, A1. Location in patent: Page/Page column 42; 44
[3] Patent: WO2010/135014, 2010, A1. Location in patent: Page/Page column 50-51
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 20, p. 8066 - 8096
[5] Patent: WO2009/23844, 2009, A2. Location in patent: Page/Page column 120

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Suppliers

Americas 1 Belgium 1 Canada 1 China 171 Europe 1 Germany 2 India 7 Japan 2 United Kingdom 8 United States 27 Global 221

Beijing Yisiyan Technology Research Center

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View Lastest Price from 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one 60832-72-6
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-22

Shaanxi Dideu Medichem Co. Ltd

Product: 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one 60832-72-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one 60832-72-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-31

60832-72-6, 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-oneRelated Search:

2,3-Lutidine Trazodone Triadimefon Zinc pyrithione 2,3-Diaminopyridine Furazolidone 2,3-Dibromopyridine Trazodone hydrochloride 2,3-Difluoropyridine Pyridine 2,3-Dihydroxypyridine 2,3-Dichloropyridine Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Oxazolo[5,4-b]pyridin-2(1H)-one (6CI,9CI) OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE Oxazolo[4,5-c]pyridin-2(3H)-one Oxazolo[4,5-b]pyridine 5-OXAZOLECARBOXALDEHYDE

(1,3 )oxazolo( 4,5-b) pyridin-2(3H)-one

2,3-Dihydropyrido[2

2,3-Dihydropyrido[2,3-d]oxazol-2-one

2H,3H-[1,3]oxazolo[4,5-b]pyridin-2-one

(1,3) OXAZOLO (4,5-B) PYRIDINE-2(3H)-ONE

3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE

2,3-DIHYDROPYRIDO[2,3-D][1,3]OXAZOL-2-ONE

[1,3]Oxazolo[4,5-b]pyridin-2-ol

oxazolo[4,5-6]pyridine-2(3h)-one

oxazolo[4,5-b]pyridin-2(3H)-one

Oxazolo[4,5-b]pyridine-2(3H)one

Oxazolo[4,5-b]pyridin-2-ol

2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one

Oxazolophridinon

2,3-Dihydropyrido[2,3-d]oxazol-2-one,97%

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one ISO 9001：2015 REACH

Crizotinib Intermediates 3

Oxazolo[4,5-b]pyridin-2(3H)-one (9CI, ACI)

3H-Oxazolo[4,5-b]pyridin-2(3H)-one

3H-Oxazolo[4,5-b]pyridin-2-one (100gx1,25gx3, 10gx5, 5gx6, 3.7gx1)

2.3-Dihydropyrido[2,3-d][1,3]oxazo1-2-one

3H-[1,3]oxazolo[4,5-b]pyridin-2-one

60832-72-6

Aromatics

Heterocycles