2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
- Product Name
- 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
- CAS No.
- 60832-72-6
- Chemical Name
- 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
- Synonyms
- Oxazolophridinon;2,3-Dihydropyrido[2;Oxazolo[4,5-b]pyridin-2-ol;Crizotinib Intermediates 3;3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE;[1,3]Oxazolo[4,5-b]pyridin-2-ol;Oxazolo[4,5-b]pyridine-2(3H)one;oxazolo[4,5-b]pyridin-2(3H)-one;oxazolo[4,5-6]pyridine-2(3h)-one;3H-Oxazolo[4,5-b]pyridin-2(3H)-one
- CBNumber
- CB0114606
- Molecular Formula
- C6H4N2O2
- Formula Weight
- 136.11
- MOL File
- 60832-72-6.mol
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Property
- Melting point:
- 214 °C
- Boiling point:
- 253.8±23.0 °C(Predicted)
- Density
- 1.59±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO, Methanol
- pka
- 2.76±0.20(Predicted)
- form
- Solid
- color
- Tan
- InChI
- InChI=1S/C6H4N2O2/c9-6-8-5-4(10-6)2-1-3-7-5/h1-3H,(H,7,8,9)
- InChIKey
- OVLXOTUWFLHWQT-UHFFFAOYSA-N
- SMILES
- C12NC(=O)OC1=CC=CN=2
- CAS DataBase Reference
- 60832-72-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38-36-22
- Safety Statements
- 22-26-36/37/39
- Hazard Note
- Harmful
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CDS005683
- Product name
- 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
- Purity
- AldrichCPR
- Packaging
- 100MG
- Price
- $68.1
- Updated
- 2023/01/07
- Product number
- O0408
- Product name
- Oxazolo[4,5-b]pyridin-2(3H)-one
- Packaging
- 5G
- Price
- $61
- Updated
- 2025/07/31
- Product number
- O0408
- Product name
- Oxazolo[4,5-b]pyridin-2(3H)-one
- Packaging
- 25G
- Price
- $184
- Updated
- 2025/07/31
- Product number
- D449430
- Product name
- 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
- Packaging
- 50g
- Price
- $950
- Updated
- 2021/12/16
- Product number
- H542
- Product name
- 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
- Packaging
- 5g
- Price
- $15
- Updated
- 2021/12/16
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Chemical Properties,Usage,Production
Chemical Properties
Tan Solid
Uses
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one is a benzoxazolone analogue that may be used to inhibit the nitric oxide synthases (NOS).
Definition
ChEBI: Oxazolo[4,5-b]pyridin-2(3H)-one is a lactone. It derives from a hydride of an oxazolo[4,5-b]pyridine.
Synthesis
16867-03-1
530-62-1
60832-72-6
N,N'-Carbonyldiimidazole (57.4 g, 354.2 mmol) was slowly added to a tetrahydrofuran (THF) solution (400 mL) of 2-amino-3-hydroxypyridine (26.0 g, 236.1 mmol, purchased from Aldrich) as described in Step 4-i of Scheme 4. The resulting reaction mixture was stirred at 70 °C for 14 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The concentrated residue was dissolved in dichloromethane (DCM) (500 mL) and subsequently washed with 2N sodium hydroxide (NaOH) solution (3 x 100 mL). The aqueous phases were combined, cooled to 0 °C, and the pH was adjusted to 6 with 6 N hydrochloric acid (HCl).At this point, the product precipitated as a precipitate, which was collected through a sintered funnel and washed with cold water (100 mL). Finally, the product was dried under vacuum to afford 2,3-dihydropyrido[2,3-d][1,3]oxazol-2-one (compound 1011, 26.0 g, 81% yield). The product was characterized by the following data: electrospray mass spectrometry (ESMS) (M + H) + m/z 137; 1H NMR (DMSO-d6) δ 12.4 (br, 1H), 8.0 (d, 1H), 7.6 (d, 1H), 7.1 (dd, 1H).
References
[1] Patent: WO2007/67416, 2007, A2. Location in patent: Page/Page column 56; 91
[2] Patent: WO2010/96389, 2010, A1. Location in patent: Page/Page column 42; 44
[3] Patent: WO2010/135014, 2010, A1. Location in patent: Page/Page column 50-51
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 20, p. 8066 - 8096
[5] Patent: WO2009/23844, 2009, A2. Location in patent: Page/Page column 120
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one manufacturers
- Product
- 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one 60832-72-6
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-22
- Product
- 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one 60832-72-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one 60832-72-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-31