ChemicalBook > CAS DataBase List > 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one

Product Name
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
CAS No.
60832-72-6
Chemical Name
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
Synonyms
Oxazolophridinon;2,3-Dihydropyrido[2;Oxazolo[4,5-b]pyridin-2-ol;Crizotinib Intermediates 3;3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE;[1,3]Oxazolo[4,5-b]pyridin-2-ol;Oxazolo[4,5-b]pyridine-2(3H)one;oxazolo[4,5-b]pyridin-2(3H)-one;oxazolo[4,5-6]pyridine-2(3h)-one;3H-Oxazolo[4,5-b]pyridin-2(3H)-one
CBNumber
CB0114606
Molecular Formula
C6H4N2O2
Formula Weight
136.11
MOL File
60832-72-6.mol
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2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Property

Melting point:
214 °C
Boiling point:
253.8±23.0 °C(Predicted)
Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO, Methanol
pka
2.76±0.20(Predicted)
form 
Solid
color 
Tan
InChI
InChI=1S/C6H4N2O2/c9-6-8-5-4(10-6)2-1-3-7-5/h1-3H,(H,7,8,9)
InChIKey
OVLXOTUWFLHWQT-UHFFFAOYSA-N
SMILES
C12NC(=O)OC1=CC=CN=2
CAS DataBase Reference
60832-72-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38-36-22
Safety Statements 
22-26-36/37/39
Hazard Note 
Harmful
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS005683
Product name
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
Purity
AldrichCPR
Packaging
100MG
Price
$68.1
Updated
2023/01/07
TCI Chemical
Product number
O0408
Product name
Oxazolo[4,5-b]pyridin-2(3H)-one
Packaging
5G
Price
$61
Updated
2025/07/31
TCI Chemical
Product number
O0408
Product name
Oxazolo[4,5-b]pyridin-2(3H)-one
Packaging
25G
Price
$184
Updated
2025/07/31
TRC
Product number
D449430
Product name
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
Packaging
50g
Price
$950
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0019385
Product name
2,3-DIHYDROPYRIDO[2,3-D][1,3]OXAZOL-2-ONE
Purity
95.00%
Packaging
2.5G
Price
$958.94
Updated
2021/12/16
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2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one is a benzoxazolone analogue that may be used to inhibit the nitric oxide synthases (NOS).

Definition

ChEBI: Oxazolo[4,5-b]pyridin-2(3H)-one is a lactone. It derives from a hydride of an oxazolo[4,5-b]pyridine.

Synthesis

16867-03-1

530-62-1

60832-72-6

N,N'-Carbonyldiimidazole (57.4 g, 354.2 mmol) was slowly added to a tetrahydrofuran (THF) solution (400 mL) of 2-amino-3-hydroxypyridine (26.0 g, 236.1 mmol, purchased from Aldrich) as described in Step 4-i of Scheme 4. The resulting reaction mixture was stirred at 70 °C for 14 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The concentrated residue was dissolved in dichloromethane (DCM) (500 mL) and subsequently washed with 2N sodium hydroxide (NaOH) solution (3 x 100 mL). The aqueous phases were combined, cooled to 0 °C, and the pH was adjusted to 6 with 6 N hydrochloric acid (HCl).At this point, the product precipitated as a precipitate, which was collected through a sintered funnel and washed with cold water (100 mL). Finally, the product was dried under vacuum to afford 2,3-dihydropyrido[2,3-d][1,3]oxazol-2-one (compound 1011, 26.0 g, 81% yield). The product was characterized by the following data: electrospray mass spectrometry (ESMS) (M + H) + m/z 137; 1H NMR (DMSO-d6) δ 12.4 (br, 1H), 8.0 (d, 1H), 7.6 (d, 1H), 7.1 (dd, 1H).

References

[1] Patent: WO2007/67416, 2007, A2. Location in patent: Page/Page column 56; 91
[2] Patent: WO2010/96389, 2010, A1. Location in patent: Page/Page column 42; 44
[3] Patent: WO2010/135014, 2010, A1. Location in patent: Page/Page column 50-51
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 20, p. 8066 - 8096
[5] Patent: WO2009/23844, 2009, A2. Location in patent: Page/Page column 120

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Suppliers

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View Lastest Price from 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one 60832-72-6
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-22
Shaanxi Dideu Medichem Co. Ltd
Product
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one 60832-72-6
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-12
Hebei Chuanghai Biotechnology Co., Ltd
Product
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one 60832-72-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31

60832-72-6, 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-oneRelated Search:

2,3-Lutidine Trazodone Triadimefon Zinc pyrithione 2,3-Diaminopyridine Furazolidone 2,3-Dibromopyridine Trazodone hydrochloride 2,3-Difluoropyridine Pyridine 2,3-Dihydroxypyridine 2,3-Dichloropyridine Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Oxazolo[5,4-b]pyridin-2(1H)-one (6CI,9CI) OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE Oxazolo[4,5-c]pyridin-2(3H)-one Oxazolo[4,5-b]pyridine 5-OXAZOLECARBOXALDEHYDE

  • (1,3 )oxazolo( 4,5-b) pyridin-2(3H)-one
  • 2,3-Dihydropyrido[2
  • 2,3-Dihydropyrido[2,3-d]oxazol-2-one
  • 2H,3H-[1,3]oxazolo[4,5-b]pyridin-2-one
  • (1,3) OXAZOLO (4,5-B) PYRIDINE-2(3H)-ONE
  • 3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE
  • 2,3-DIHYDROPYRIDO[2,3-D][1,3]OXAZOL-2-ONE
  • [1,3]Oxazolo[4,5-b]pyridin-2-ol
  • oxazolo[4,5-6]pyridine-2(3h)-one
  • oxazolo[4,5-b]pyridin-2(3H)-one
  • Oxazolo[4,5-b]pyridine-2(3H)one
  • Oxazolo[4,5-b]pyridin-2-ol
  • 2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one
  • Oxazolophridinon
  • 2,3-Dihydropyrido[2,3-d]oxazol-2-one,97%
  • 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one ISO 9001：2015 REACH
  • Crizotinib Intermediates 3
  • Oxazolo[4,5-b]pyridin-2(3H)-one (9CI, ACI)
  • 3H-Oxazolo[4,5-b]pyridin-2(3H)-one
  • 3H-Oxazolo[4,5-b]pyridin-2-one (100gx1,25gx3, 10gx5, 5gx6, 3.7gx1)
  • 2.3-Dihydropyrido[2,3-d][1,3]oxazo1-2-one
  • 3H-[1,3]oxazolo[4,5-b]pyridin-2-one
  • 60832-72-6
  • Aromatics
  • Heterocycles