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Losartan Carboxaldehyde

Product Name
Losartan Carboxaldehyde
CAS No.
114798-36-6
Chemical Name
Losartan Carboxaldehyde
Synonyms
DUP 167;EXP 3179;Losartan Aldehyde;Losartan EP IMpurity K;Losartan Carboxaldehyde;Losartan Impurity K (EP);Losartan Carboxaldehyde-d3;Losartan Related CoMpound C;Losartan Potassium Impurity K;Losartan USP Related Compound C
CBNumber
CB01176401
Molecular Formula
C22H21ClN6O
Formula Weight
420.89
MOL File
114798-36-6.mol
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Losartan Carboxaldehyde Property

Melting point:
84-86°C
Boiling point:
666.7±65.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator, Under Inert Atmosphere
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form 
Solid
pka
4.16±0.10(Predicted)
color 
Off-White to Light Yellow
CAS DataBase Reference
114798-36-6
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Safety

HS Code 
2933290000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18855
Product name
Losartan Carboxaldehyde
Purity
≥95%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
18855
Product name
Losartan Carboxaldehyde
Purity
≥95%
Packaging
5mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
18855
Product name
Losartan Carboxaldehyde
Purity
≥95%
Packaging
10mg
Price
$249
Updated
2024/03/01
TRC
Product number
L470505
Product name
LosartanCarboxaldehyde
Packaging
50mg
Price
$670
Updated
2021/12/16
Usbiological
Product number
281287
Product name
Losartan carboxaldehyde
Packaging
2mg
Price
$345
Updated
2021/12/16
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Losartan Carboxaldehyde Chemical Properties,Usage,Production

Description

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.

Chemical Properties

Yellow Solid

Uses

A metabolite of Losartan. An intermediate in the synthesis of the EXP 3174

Uses

A labelled intermediate in the synthesis of the EXP 3174, a metabolite of Losartan

Uses

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.[Cayman Chemical]

in vitro

losartan is an intermediate aldehyde metabolite of losartan, the angiotensin ii type 1 receptor antagonist. losartan could not block angiotensin receptors, but inhibit the expression of endothelial cyclooxygenase (cox)-2, therefore exerting anti-inflammatory actions. moreover, losartan at 1 μm was able to block the upregulation of icam-1 mrna and cox-dependent generation of thromboxane a2 and prostaglandin f2α [1].

in vivo

in animal stufdy, losartan was infused for 10 days to rats on a normal sodium intake (nna) and rats on a high sodium intake (hna) to suppress endogenous ang ii. although basal plasma renin activity was markedly suppressed in hna rats compared with nna rats, control arterial pressure was not different between nna and hna rats. losartan could decrease arterial pressure from control levels in nna rats on the first day of infusion but had no effect on arterial pressure in hna rats. in addition, by day 10 of losartan infusion, arterial pressure had decreased further from control levels in nna rats but remained unchanged compared with control in hna rats [2].

References

[1] c. kr mer, j. sunkomat, j. witte, et al. angiotensin ii receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite exp3179. circulation research 90(7), 770-776 (2002).
[2] collister jp, hornfeldt bj, osborn jw. hypotensive response to losartan in normal rats. role of ang ii and the area postrema. hypertension. 1996 mar;27(3 pt 2):598-606.
[3] goa kl, wagstaff aj. losartan potassium: a review of its pharmacology, clinical efficacy and tolerability in the management of hypertension. drugs. 1996 may;51(5):820-45.

Losartan Carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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Losartan Carboxaldehyde Suppliers

Canada 1 China 67 India 8 United States 9 Global 85
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
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View Lastest Price from Losartan Carboxaldehyde manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Allisartan Isoproxil Impurity 14 114798-36-6
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-01
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Allisartan Isoproxil Impurity 14 114798-36-6
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-01

114798-36-6, Losartan CarboxaldehydeRelated Search:

Losartan carboxylic acid N2-Losartanyl-losartan (Losartan IMpurity) Losartan IsoMer IMpurity, PotassiuM Salt 2'-[(1H-Tetrazol-5-yl)biphenyl-4-yl]Methanol N1-Losartanyl-losartan (Losartan IMpurity) Triphenylmethanol 2-Butyl-4-chloro-5-formylimidazole Losartan Impurity D 5-(4'-((2-butyl-4-chloro-5-(isopropoxymethyl)-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-1H-tetrazole (2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL 5-[2-(4'-METHYLBIPHENYL)]TETRAZOLE Losartan IMpurity C (Isolosartan) O-Acetyl Losartan Losartan potassium Losartan Losartan Carboxaldehyde AKOS 91711 AKOS 91707

  • 2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde
  • DUP 167
  • EXP 3179
  • Losartan Carboxaldehyde Discontinued see product # L470505
  • Losartan Carboxaldehyde
  • 2-(Butyl-d3)-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde
  • Losartan Carboxaldehyde-d3
  • Losartan EP Impurity K (Losartan Carboxaldehyde)
  • 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carbaldehyde
  • Losartan EP IMpurity K (LosaratnCarboxaldehyde)
  • Losartan EP IMpurity K
  • Losartan Related CoMpound C
  • Losartan Aldehyde
  • 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde
  • Losartan Impurity K (EP)
  • 2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-formaldehyde
  • Losartan Impurity 11(Losartan EP Impurity K)
  • Losartan EP Impurity K:Losartan Impurity K
  • 1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
  • Allisartan Isoproxil impurity II
  • Losartan EP Impurity K/ Losartan Related Compound C (Losartan Aldehyde)
  • Losartan Carboxaldehyde_x000b_Discontinued see product # L470505
  • Losartan Related Compound C (2-Butyl-4-chloro-1-[[2''-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imi (1370495)
  • Losartan USP Related Compound C
  • DuP 167,EXP-3179,DuP-167,Inhibitor,COX,AT1-R–blocking,intermediate aldehyde metabolite,Cyclooxygenase,COX-2,EXP3179,inhibit,EXP 3179,Losartan,Losartan Carboxaldehyde,anti-inflammatory,DuP167
  • Losartan Potassium EP Impurity K
  • Losartan Potassium Impurity K
  • 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde
  • Losartan EP Impurity K (Losartan USP Related Compound C, Losartan Carboxaldehyde)
  • Losartan EP Impurity K Losartan USP RC C
  • 114798-36-6
  • 14798-36-6
  • C22H21ClN6O
  • Intermediates & Fine Chemicals
  • Isotope Labelled Compounds
  • Metabolites & Impurities
  • Pharmaceuticals
  • Isotope Labeled Compounds