ChemicalBook > CAS DataBase List > 2-Butyl-4-chloro-5-formylimidazole

2-Butyl-4-chloro-5-formylimidazole

Product Name
2-Butyl-4-chloro-5-formylimidazole
CAS No.
83857-96-9
Chemical Name
2-Butyl-4-chloro-5-formylimidazole
Synonyms
BCFI;2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE;2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBALDEHYDE;2-Butyl-4-chloroimidazole-5-carboxaldehyde;Losaint-A;ALSTint-A03;Losartan potassium-1;LOSARTAN INTERMEDIATES;Losartan EP IMpurity D;Losartan impurity D CRS
CBNumber
CB4185349
Molecular Formula
C8H11ClN2O
Formula Weight
186.64
MOL File
83857-96-9.mol
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2-Butyl-4-chloro-5-formylimidazole Property

Melting point:
97-100 °C(lit.)
Boiling point:
384.1±22.0 °C(Predicted)
Density 
1.240
vapor pressure 
0.001Pa at 25℃
storage temp. 
Inert atmosphere,2-8°C
solubility 
soluble in methanol
form 
Powder to crystal
pka
8.87±0.10(Predicted)
color 
Pale Yellow to Brown
Water Solubility 
slightly soluble
InChIKey
JLVIHQCWASNXCK-UHFFFAOYSA-N
LogP
2.5 at 25℃ and pH7.1
Surface tension
58.3mN/m at 1.2g/L and 20℃
CAS DataBase Reference
83857-96-9(CAS DataBase Reference)
EPA Substance Registry System
2-Butyl-5-chloroimidazole-4-carbaldehyde (83857-96-9)
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Safety

Hazard Codes 
Xi,N
Risk Statements 
43-51/53
Safety Statements 
24-37-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
2
HazardClass 
IRRITANT
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1370473
Product name
Losartan Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
20mg
Price
$1210
Updated
2024/03/01
Sigma-Aldrich
Product number
559881
Product name
2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde
Purity
97%
Packaging
25g
Price
$169
Updated
2023/01/07
TCI Chemical
Product number
B2914
Product name
2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde
Purity
>98.0%(GC)
Packaging
25g
Price
$36
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001072
Product name
Losartan impurity D
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001072
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
T136964
Product name
2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE
Purity
Aldrich
Packaging
50mg
Price
$179
Updated
2024/03/01
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2-Butyl-4-chloro-5-formylimidazole Chemical Properties,Usage,Production

Description

2-Butyl-4-chloro-5-formylimidazole is an API intermediate used as an intermediate for the anti-hypertensive drug Chlosartan. It can be used in the chemical manufacture of many APIs and advanced intermediates. With the help of this chemical, a number of other chemicals can be manufactured that have further applications in industries such as Losartan manufacturing.

Chemical Properties

2-Butyl-4-chloro-5-formylimidazole is Yellow Solid

Uses

2-Butyl-4-chloro-5-formylimidazole is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists

Uses

2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde may be used in the preparation of the following symmetrical esters of dialkyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate:

  • dimethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • diethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • diisopropyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • diisobutyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • di-tert-butyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • bis(2-methoxyethyl) 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Application

2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde (Losartan EP Impurity D) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists. Losartan USP Related Compound A.

Synthesis Reference(s)

The Journal of Organic Chemistry, 64, p. 8084, 1999 DOI: 10.1021/jo9824910

Synthesis

2-Butyl-4-chloro-5-formylimidazole was synthesised as follows: Performing condensation reaction of pentamidine hydrochloride with glyoxal and controlling the pH value of the system in the range of 6.0-7.5; after the reaction terminates, arousing dehydration reaction of the compound of formula III, thereby obtaining 2-butyl-1H-imidazole-5(4H)-ketone; and finally, reacting 2-butyl-1H-imidazole-5(4H)-ketone with N,N-dimethylformamide in the presence of phosphorus oxychloride, thereby obtaining 2-butyl-4-chloro-5-formylimidazole.

storage

2-Butyl-4-chloro-5-formylimidazole is soluble in DMF, DMSO, Ethanol and Methanol.

2-Butyl-4-chloro-5-formylimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Butyl-4-chloro-5-formylimidazole Suppliers

TaiZhou ZhiCheng Chemicals & Technology Co., LTD.
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0523-82837785 13365232216
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0523-87913272
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info@jszchg.com
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China
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Harway Pharma CO., LTD
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0546-5612566 13793982289
Fax
0546-5180666
Email
lucy@harwaypharma.com
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China
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JUYE XIANDAI fine chemistry Co.,Ltd
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13566887771
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8459310@qq.com
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006608290; 18621169109
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86-21-61259102
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market03@meryer.com
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China
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future industrial shanghai co., ltd
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400-0066400 13621662912
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021-55660885
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sales@jonln.com
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China
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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021-67121385
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Sales-CN@TCIchemicals.com
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China
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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sales@capotchem.com
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
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isenchem@163.com
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China
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View Lastest Price from 2-Butyl-4-chloro-5-formylimidazole manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
2-Butyl-4-chloro-5-formylimidazole 83857-96-9
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000KG
Release date
2023-08-30
Hebei Mingeng Biotechnology Co., Ltd
Product
2-Butyl-4-Chloro-5-Formylimidazole 83857-96-9
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Month
Release date
2022-11-28
Changzhou Rokechem Technology Co., Ltd.
Product
2-Butyl-4-chloro-1H-imidazole-5-carbaldehyde 83857-96-9
Price
US $0.10-1.00/Kg
Min. Order
1Kg
Purity
99%
Supply Ability
1-10000kgs
Release date
2023-05-24

83857-96-9, 2-Butyl-4-chloro-5-formylimidazoleRelated Search:


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