2-Butyl-4-chloro-5-formylimidazole
- Product Name
- 2-Butyl-4-chloro-5-formylimidazole
- CAS No.
- 83857-96-9
- Chemical Name
- 2-Butyl-4-chloro-5-formylimidazole
- Synonyms
- BCFI;2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE;2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBALDEHYDE;2-Butyl-4-chloroimidazole-5-carboxaldehyde;Losaint-A;ALSTint-A03;Losartan potassium-1;LOSARTAN INTERMEDIATES;Losartan EP IMpurity D;Losartan impurity D CRS
- CBNumber
- CB4185349
- Molecular Formula
- C8H11ClN2O
- Formula Weight
- 186.64
- MOL File
- 83857-96-9.mol
2-Butyl-4-chloro-5-formylimidazole Property
- Melting point:
- 97-100 °C(lit.)
- Boiling point:
- 384.1±22.0 °C(Predicted)
- Density
- 1.240
- vapor pressure
- 0.001Pa at 25℃
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- soluble in methanol
- form
- Powder to crystal
- pka
- 8.87±0.10(Predicted)
- color
- Pale Yellow to Brown
- Water Solubility
- slightly soluble
- InChIKey
- JLVIHQCWASNXCK-UHFFFAOYSA-N
- LogP
- 2.5 at 25℃ and pH7.1
- Surface tension
- 58.3mN/m at 1.2g/L and 20℃
- CAS DataBase Reference
- 83857-96-9(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Butyl-5-chloroimidazole-4-carbaldehyde (83857-96-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 1370473
- Product name
- Losartan Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 20mg
- Price
- $1210
- Updated
- 2024/03/01
- Product number
- 559881
- Product name
- 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde
- Purity
- 97%
- Packaging
- 25g
- Price
- $169
- Updated
- 2023/01/07
- Product number
- B2914
- Product name
- 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $36
- Updated
- 2024/03/01
- Product number
- Y0001072
- Product name
- Losartan impurity D
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001072
- Price
- $153
- Updated
- 2024/03/01
- Product number
- T136964
- Product name
- 2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE
- Purity
- Aldrich
- Packaging
- 50mg
- Price
- $179
- Updated
- 2024/03/01
2-Butyl-4-chloro-5-formylimidazole Chemical Properties,Usage,Production
Description
2-Butyl-4-chloro-5-formylimidazole is an API intermediate used as an intermediate for the anti-hypertensive drug Chlosartan. It can be used in the chemical manufacture of many APIs and advanced intermediates. With the help of this chemical, a number of other chemicals can be manufactured that have further applications in industries such as Losartan manufacturing.
Chemical Properties
2-Butyl-4-chloro-5-formylimidazole is Yellow Solid
Uses
2-Butyl-4-chloro-5-formylimidazole is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists
Uses
2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde may be used in the preparation of the following symmetrical esters of dialkyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate:
- dimethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- diethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- diisopropyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- diisobutyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- di-tert-butyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- bis(2-methoxyethyl) 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Application
2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde (Losartan EP Impurity D) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists. Losartan USP Related Compound A.
Synthesis Reference(s)
The Journal of Organic Chemistry, 64, p. 8084, 1999 DOI: 10.1021/jo9824910
Synthesis
2-Butyl-4-chloro-5-formylimidazole was synthesised as follows: Performing condensation reaction of pentamidine hydrochloride with glyoxal and controlling the pH value of the system in the range of 6.0-7.5; after the reaction terminates, arousing dehydration reaction of the compound of formula III, thereby obtaining 2-butyl-1H-imidazole-5(4H)-ketone; and finally, reacting 2-butyl-1H-imidazole-5(4H)-ketone with N,N-dimethylformamide in the presence of phosphorus oxychloride, thereby obtaining 2-butyl-4-chloro-5-formylimidazole.
storage
2-Butyl-4-chloro-5-formylimidazole is soluble in DMF, DMSO, Ethanol and Methanol.
2-Butyl-4-chloro-5-formylimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
2-Butyl-4-chloro-5-formylimidazole Suppliers
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View Lastest Price from 2-Butyl-4-chloro-5-formylimidazole manufacturers
- Product
- 2-Butyl-4-chloro-5-formylimidazole 83857-96-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-19
- Product
- 2-Butyl-4-chloro-5-formylimidazole 83857-96-9
- Price
- US $1.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-08-13
- Product
- 2-Butyl-4-chloro-5-formylimidazole 83857-96-9
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000KG
- Release date
- 2023-08-30