ChemicalBook > CAS DataBase List > 2-Butyl-4-chloro-5-formylimidazole

2-Butyl-4-chloro-5-formylimidazole

Product Name
2-Butyl-4-chloro-5-formylimidazole
CAS No.
83857-96-9
Chemical Name
2-Butyl-4-chloro-5-formylimidazole
Synonyms
BCFI;2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE;2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBALDEHYDE;2-Butyl-4-chloroimidazole-5-carboxaldehyde;Losaint-A;ALSTint-A03;Losartan potassium-1;LOSARTAN INTERMEDIATES;Losartan EP IMpurity D;Losartan impurity D CRS
CBNumber
CB4185349
Molecular Formula
C8H11ClN2O
Formula Weight
186.64
MOL File
83857-96-9.mol
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2-Butyl-4-chloro-5-formylimidazole Property

Melting point:
97-100 °C(lit.)
Boiling point:
384.1±22.0 °C(Predicted)
Density 
1.240
vapor pressure 
0.001Pa at 25℃
storage temp. 
Inert atmosphere,2-8°C
solubility 
soluble in methanol
form 
Powder to crystal
pka
8.87±0.10(Predicted)
color 
Pale Yellow to Brown
Water Solubility 
slightly soluble
InChIKey
JLVIHQCWASNXCK-UHFFFAOYSA-N
LogP
2.5 at 25℃ and pH7.1
Surface tension
58.3mN/m at 1.2g/L and 20℃
CAS DataBase Reference
83857-96-9(CAS DataBase Reference)
EPA Substance Registry System
2-Butyl-5-chloroimidazole-4-carbaldehyde (83857-96-9)
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Safety

Hazard Codes 
Xi,N
Risk Statements 
43-51/53
Safety Statements 
24-37-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
2
HazardClass 
IRRITANT
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1370473
Product name
Losartan Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
20mg
Price
$1210
Updated
2024/03/01
Sigma-Aldrich
Product number
559881
Product name
2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde
Purity
97%
Packaging
25g
Price
$169
Updated
2023/01/07
TCI Chemical
Product number
B2914
Product name
2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde
Purity
>98.0%(GC)
Packaging
25g
Price
$36
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001072
Product name
Losartan impurity D
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001072
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
T136964
Product name
2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE
Purity
Aldrich
Packaging
50mg
Price
$179
Updated
2024/03/01
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2-Butyl-4-chloro-5-formylimidazole Chemical Properties,Usage,Production

Description

2-Butyl-4-chloro-5-formylimidazole is an API intermediate used as an intermediate for the anti-hypertensive drug Chlosartan. It can be used in the chemical manufacture of many APIs and advanced intermediates. With the help of this chemical, a number of other chemicals can be manufactured that have further applications in industries such as Losartan manufacturing.

Chemical Properties

2-Butyl-4-chloro-5-formylimidazole is Yellow Solid

Uses

2-Butyl-4-chloro-5-formylimidazole is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists

Uses

2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde may be used in the preparation of the following symmetrical esters of dialkyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate:

  • dimethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • diethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • diisopropyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • diisobutyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • di-tert-butyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • bis(2-methoxyethyl) 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Application

2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde (Losartan EP Impurity D) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists. Losartan USP Related Compound A.

Synthesis Reference(s)

The Journal of Organic Chemistry, 64, p. 8084, 1999 DOI: 10.1021/jo9824910

Synthesis

2-Butyl-4-chloro-5-formylimidazole was synthesised as follows: Performing condensation reaction of pentamidine hydrochloride with glyoxal and controlling the pH value of the system in the range of 6.0-7.5; after the reaction terminates, arousing dehydration reaction of the compound of formula III, thereby obtaining 2-butyl-1H-imidazole-5(4H)-ketone; and finally, reacting 2-butyl-1H-imidazole-5(4H)-ketone with N,N-dimethylformamide in the presence of phosphorus oxychloride, thereby obtaining 2-butyl-4-chloro-5-formylimidazole.

storage

2-Butyl-4-chloro-5-formylimidazole is soluble in DMF, DMSO, Ethanol and Methanol.

2-Butyl-4-chloro-5-formylimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Butyl-4-chloro-5-formylimidazole Suppliers

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View Lastest Price from 2-Butyl-4-chloro-5-formylimidazole manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2-Butyl-4-chloro-5-formylimidazole 83857-96-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-19
Hebei Chuanghai Biotechnology Co,.LTD
Product
2-Butyl-4-chloro-5-formylimidazole 83857-96-9
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-13
Hebei Mojin Biotechnology Co., Ltd
Product
2-Butyl-4-chloro-5-formylimidazole 83857-96-9
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000KG
Release date
2023-08-30

83857-96-9, 2-Butyl-4-chloro-5-formylimidazoleRelated Search:

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  • 2-BUTYL-4-CHLORO-5-IMIDAZOLECARBOXALDEHYDE (BCFI)
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  • 2-butyl-4-chloro-5-imidazolecarboxyaldehyde
  • 2-n-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde
  • 2-Butyl-4(5)-chloro-1H-imidazole-5(4)-carbaldehyde
  • 2-Butyl-5-chloro-1H-imidazole-4-carbaldehyde ,99%
  • 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde,2-Butyl-4-chloro-5-formylimidazole
  • 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde 97%
  • 2-(But-1-yl)-5-chloro-1H-imidazole-4-carboxaldehyde 97%
  • 2-(But-1-yl)-5-chloro-4-formyl-1H-imidazole
  • Ethyl(2S)-2-[(3S,8aS)-3-Methyl-1,4-dioxo-octahydropyrrolo[1,2-alpha]pyrazin-2-yl]-4-phenylbutanoate
  • 2-n-Butyl-4(5)-Chloro-1H-IMidazole-5(4)-Carboxaldehyde (BCFI)
  • 2-Butyl-4-chloro-5-formylimidazole,99%
  • 2-N-Butyl-4-chloro-5-Formyl Imidazole (BCFI)
  • Losartan potassium-1
  • 2-(But-1-yl)-5-chloro-1H-imidazole-4-carboxaldehyde
  • Losartan potassium impurity A
  • LOSARTAN INTERMEDIATES
  • 2-n-butyl-4(5)-Chloro-1H-imdazole-5(4)-carboxaldehyde
  • 2-Butyl-5-chloro-4-formylimidazole
  • 2-Butyl-5-choloro-1H-imidazole-4-carbaldehyde
  • 2-Butyl-4-chloro-5-imidazolecarboxaldehyde
  • 2-Butyl-5-Chloro-1H-Imidagole-4-Carbaldehyde
  • 2-Buty1-4(5)-Chloro-5(4)Imidazolecarboxaldehyde
  • 2N-Butyl-4(5)-Chloro-1H-Imidazole-5(4)-Oarboxaldehyde
  • 2-BUTYL-5-CHLOROIMIDAZOLE-4-CARBOXALDEHYDE
  • 2-BUTYL-4-CHLORO-IMIDAZOLE-5-CARBALDEHYDE
  • 2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBALDEHYDE
  • 2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBOXALDEHYDE
  • 2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE
  • 2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBOXALDEHYDE
  • 2-BUTYL-4-CHLORO-5-FORMYLIMIDAZLOE
  • 2-BUTYL-4-CHLORO-5-FORMYLIMIDAZOLE
  • 2-BUTYL-4(5)-CHLORO-5(4)IMIDAZOLECARBOXALDEHYDE
  • 2-N-BUTYL-5-CHLORO-4-FORMYL IMIDAZOLE
  • 2-N-BUTYL-4(5)-CHLORO-1H-IMIDAZOLE-5(4)-CARBOXALDEHYDE
  • 2-N-BUTYL-4-CHLORO-5-FORMYLIMIDAZOLE
  • 2-N-BUTYL-4-CHLOROIMIDAZOLE-5-CARBOXALDEHYDE
  • 2-Butyl-5-chloro-1H-imidazole carboxaldehyde
  • 2-Butyl-4(5)-chloro-5(4)-imidazolecarboxyaldehyde
  • Losartan EP IMpurity D
  • 2- butyl-4-chloro -5-forMyl iMidazoles
  • (2-n-Butyl-5-chloro-imidazole-4-yl)-carboxaldehyde
  • 2-Butyl-4-chloro-5-formylimidazole (BCFI)
  • ALSTint-A03
  • Losaint-A
  • Losartan Impurity D (EP)
  • Losartan Impurity 4(Losartan EP Impurity D)
  • Losartan Potassium EP Impurity D
  • Losartan impurity D CRS
  • 2-Butyl-4-chloro-1H-imidazole-5-car
  • 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde &gt