Brequinar

Product Name: Brequinar
CAS No.: 96187-53-0
Chemical Name: Brequinar
Synonyms: BPQ;CS-157;Brequinar;Biphenquinate;Brequinar (DUP785);Brequinar, 10 mM in DMSO;BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.;6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl);6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl;6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid
CBNumber: CB01178142
Molecular Formula: C23H15F2NO2
Formula Weight: 375.37
MOL File: 96187-53-0.mol

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Brequinar Property

Melting point:: 355-357℃ (N,N-dimethylformamide water )
storage temp.: 2-8°C
solubility: DMSO:25.9(Max Conc. mg/mL);70.0(Max Conc. mM)
form: powder to crystal
pka: pKa 4.45(H2O t=RT I=0.10) (Uncertain)
color: White to Light yellow
CAS DataBase Reference: 96187-53-0

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Safety

HS Code: 2933.49.7000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5707
Product name: Brequinar
Purity: >98.0%(HPLC)
Packaging: 20mg
Price: $161
Updated: 2024/03/01

TCI Chemical

Product number: B5707
Product name: Brequinar
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $531
Updated: 2024/03/01

Cayman Chemical

Product number: 24445
Product name: Brequinar
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 24445
Product name: Brequinar
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 24445
Product name: Brequinar
Purity: ≥98%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

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Brequinar Chemical Properties,Usage,Production

Uses

Antineoplastic.

Definition

ChEBI: Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, an antineoplastic agent, an antiviral agent, a pyrimidine synthesis inhibitor, an anticoronaviral agent and an antimetabolite. It is a member of biphenyls, a member of monofluorobenzenes, a quinolinemonocarboxylic acid and a monocarboxylic acid. It is a conjugate acid of a brequinar(1-).

Biological Activity

Brequinar exhibits anti-neoplastic activity against refractory solid tumors in human and mouse models. Continuous treatment is required for depletion of pyrimidine pools in the cancer cells and tumor inhibition.', 'Brequinar inhibits dihydroorotate dehydrogenase (DHODH), the fourth enzyme in the de novo pyrimidine biosynthesis pathway, preventing the synthesis of DNA and RNA. Brequinar has recently been found to have antiviral activity against a broad spectrum of viruses including flaviviruses (dengue virus, West Nile virus, yellow fever virus, and Powassan virus) and also a plus-strand RNA alphavirus (Western equine encephalitis virus) and a negative-strand RNA rhabdovirus (vesicular stomatitis virus).

Brequinar Preparation Products And Raw materials

Raw materials

Preparation Products

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Brequinar Suppliers

Americas 1 CHINA 82 Europe 1 India 3 Japan 1 United Kingdom 1 United States 14 Global 103

Shanghai Boyle Chemical Co., Ltd.

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96187-53-0, BrequinarRelated Search:

Quinapril SODIUM 4-PYRIDINECARBOXYLATE TETRAHYDRATE 3-METHYLQUINOLINE-4-CARBOXYLIC ACID 6-Fluoroquinaldine 3-METHYL-2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID Brequinar 4-METHYL-2-P-TOLYL-PYRIDINE 2-P-TOLYL-QUINOLINE-4-CARBOXYLIC ACID 6-FLUORO-2-METHYLQUINOLINE-4-CARBOXYLIC ACID 2-BIPHENYL-4-YL-QUINOLINE-4-CARBOXYLIC ACID

Brequinar

6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid

6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid

6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl

4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-Methyl-

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid

Biphenquinate

BPQ

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)

Brequinar (DUP785)

BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.

6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid

CS-157

NSC-368390,DHODH,Inhibitor,DUP 785,Brequinar,Virus Protease,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis,SARS coronavirus,inhibit,DUP-785,SARS-CoV,NSC368390

6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylicaci

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid

Brequinar, 10 mM in DMSO

96187-53-0

C22H13F2NO2

C23H15F2NO2

API