Brequinar

Product Name: Brequinar
CAS No.: 96187-53-0
Chemical Name: Brequinar
Synonyms: BPQ;CS-157;Brequinar;Biphenquinate;Brequinar (DUP785);BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.;6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl);6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl;6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid;6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylicaci
CBNumber: CB01178142
Molecular Formula: C23H15F2NO2
Formula Weight: 375.37
MOL File: 96187-53-0.mol

More

Less

Brequinar Property

Melting point:: 355-357℃ (N,N-dimethylformamide water )
storage temp.: 2-8°C
solubility: DMSO:25.9(Max Conc. mg/mL);70.0(Max Conc. mM)
form: powder to crystal
pka: pKa 4.45(H2O t=RT I=0.10) (Uncertain)
color: White to Light yellow
CAS DataBase Reference: 96187-53-0

More

Less

Safety

HS Code: 2933.49.7000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B5707
Product name: Brequinar
Purity: >98.0%(HPLC)
Packaging: 20mg
Price: $161
Updated: 2024/03/01

TCI Chemical

Product number: B5707
Product name: Brequinar
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $531
Updated: 2024/03/01

Cayman Chemical

Product number: 24445
Product name: Brequinar
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 24445
Product name: Brequinar
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 24445
Product name: Brequinar
Purity: ≥98%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

More

Less

Brequinar Chemical Properties,Usage,Production

Uses

Antineoplastic.

Definition

ChEBI: Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, an antineoplastic agent, an antiviral agent, a pyrimidine synthesis inhibitor, an anticoronaviral agent and an antimetabolite. It is a member of biphenyls, a member of monofluorobenzenes, a quinolinemonocarboxylic acid and a monocarboxylic acid. It is a conjugate acid of a brequinar(1-).

Brequinar Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Brequinar Suppliers

Americas 1 CHINA 78 Europe 1 India 3 Japan 1 United Kingdom 1 United States 14 Global 99

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

ChemFuture PharmaTech (Jiangsu) Ltd

Tel: 5108538618
Fax: 86 510 85386988-8017
Email: suger.wang@chemfuture.com
Country: China
ProdList: 832
Advantage: 65

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7195
Advantage: 65

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 9387
Advantage: 52

Shanghai Sphchem Co., Ltd.

Tel: 21-21-56491756 13512199871
Fax: 021-5649-1756
Email: sales@panhongchem.com
Country: China
ProdList: 4000
Advantage: 55

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

96187-53-0, BrequinarRelated Search:

Quinapril SODIUM 4-PYRIDINECARBOXYLATE TETRAHYDRATE 3-METHYLQUINOLINE-4-CARBOXYLIC ACID 6-Fluoroquinaldine 3-METHYL-2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID Brequinar 4-METHYL-2-P-TOLYL-PYRIDINE 2-P-TOLYL-QUINOLINE-4-CARBOXYLIC ACID 6-FLUORO-2-METHYLQUINOLINE-4-CARBOXYLIC ACID 2-BIPHENYL-4-YL-QUINOLINE-4-CARBOXYLIC ACID

Brequinar

6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid

6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid

6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl

4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-Methyl-

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid

Biphenquinate

BPQ

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)

Brequinar (DUP785)

BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.

6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid

CS-157

NSC-368390,DHODH,Inhibitor,DUP 785,Brequinar,Virus Protease,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis,SARS coronavirus,inhibit,DUP-785,SARS-CoV,NSC368390

6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylicaci

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid

96187-53-0

C22H13F2NO2

C23H15F2NO2

API