Brequinar
- Product Name
- Brequinar
- CAS No.
- 96187-53-0
- Chemical Name
- Brequinar
- Synonyms
- BPQ;CS-157;Brequinar;Biphenquinate;Brequinar (DUP785);Brequinar, 10 mM in DMSO;BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.;6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl);6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl;6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid
- CBNumber
- CB01178142
- Molecular Formula
- C23H15F2NO2
- Formula Weight
- 375.37
- MOL File
- 96187-53-0.mol
Brequinar Property
- Melting point:
- 355-357℃ (N,N-dimethylformamide water )
- storage temp.
- 2-8°C
- solubility
- DMSO:25.9(Max Conc. mg/mL);70.0(Max Conc. mM)
- form
- powder to crystal
- pka
- pKa 4.45(H2O t=RT I=0.10) (Uncertain)
- color
- White to Light yellow
- CAS DataBase Reference
- 96187-53-0
Safety
- HS Code
- 2933.49.7000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0113
- Product name
- Brequinar sodium salt hydrate
- Purity
- ≥97% (HPLC)
- Packaging
- 5 mg
- Price
- $140
- Updated
- 2025/07/31
- Product number
- SML0113
- Product name
- Brequinar sodium salt hydrate
- Purity
- ≥97% (HPLC)
- Packaging
- 25 mg
- Price
- $530
- Updated
- 2025/07/31
- Product number
- B5707
- Product name
- Brequinar
- Purity
- >98.0%(HPLC)
- Packaging
- 20mg
- Price
- $161
- Updated
- 2025/07/31
- Product number
- B5707
- Product name
- Brequinar
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $531
- Updated
- 2025/07/31
- Product number
- 24445
- Product name
- Brequinar
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Brequinar Chemical Properties,Usage,Production
Uses
Antineoplastic.
Definition
ChEBI: Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, an antineoplastic agent, an antiviral agent, a pyrimidine synthesis inhibitor, an anticoronaviral agent and an antimetabolite. It is a member of biphenyls, a member of monofluorobenzenes, a quinolinemonocarboxylic acid and a monocarboxylic acid. It is a conjugate acid of a brequinar(1-).
Biological Activity
Brequinar exhibits anti-neoplastic activity against refractory solid tumors in human and mouse models. Continuous treatment is required for depletion of pyrimidine pools in the cancer cells and tumor inhibition.', 'Brequinar inhibits dihydroorotate dehydrogenase (DHODH), the fourth enzyme in the de novo pyrimidine biosynthesis pathway, preventing the synthesis of DNA and RNA. Brequinar has recently been found to have antiviral activity against a broad spectrum of viruses including flaviviruses (dengue virus, West Nile virus, yellow fever virus, and Powassan virus) and also a plus-strand RNA alphavirus (Western equine encephalitis virus) and a negative-strand RNA rhabdovirus (vesicular stomatitis virus).
in vivo
Brequinar sodium-treated (10-20 mg/kg/day) mice has a 31% reduction in percentage of packed cell volume compared with untreated BALB/c mice. Brequinar sodium reduces UTP and CTP levels in bone marrow cells by 30 and 25%, respectively. Brequinar sodium (10-20 mg/kg/day) in combination with uridine (1000-2000 mg/kg/day) prevents anemia, and the hematocrits remain at levels (61-63%) comparable with those of untreated controls[3].
Brequinar Preparation Products And Raw materials
Raw materials
Preparation Products
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