ChemicalBook > CAS DataBase List > Brequinar

Brequinar

Product Name
Brequinar
CAS No.
96187-53-0
Chemical Name
Brequinar
Synonyms
BPQ;CS-157;Brequinar;Biphenquinate;Brequinar (DUP785);BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.;6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl);6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl;6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid;6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylicaci
CBNumber
CB01178142
Molecular Formula
C23H15F2NO2
Formula Weight
375.37
MOL File
96187-53-0.mol
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Brequinar Property

Melting point:
355-357℃ (N,N-dimethylformamide water )
storage temp. 
2-8°C
solubility 
DMSO:25.9(Max Conc. mg/mL);70.0(Max Conc. mM)
form 
powder to crystal
pka
pKa 4.45(H2O t=RT I=0.10) (Uncertain)
color 
White to Light yellow
CAS DataBase Reference
96187-53-0
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Safety

HS Code 
2933.49.7000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5707
Product name
Brequinar
Purity
>98.0%(HPLC)
Packaging
20mg
Price
$161
Updated
2024/03/01
TCI Chemical
Product number
B5707
Product name
Brequinar
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$531
Updated
2024/03/01
Cayman Chemical
Product number
24445
Product name
Brequinar
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
24445
Product name
Brequinar
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
24445
Product name
Brequinar
Purity
≥98%
Packaging
10mg
Price
$199
Updated
2024/03/01
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Brequinar Chemical Properties,Usage,Production

Uses

Antineoplastic.

Definition

ChEBI: Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, an antineoplastic agent, an antiviral agent, a pyrimidine synthesis inhibitor, an anticoronaviral agent and an antimetabolite. It is a member of biphenyls, a member of monofluorobenzenes, a quinolinemonocarboxylic acid and a monocarboxylic acid. It is a conjugate acid of a brequinar(1-).

Brequinar Preparation Products And Raw materials

Raw materials

Preparation Products

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Brequinar Suppliers

Americas 1 CHINA 78 Europe 1 India 3 Japan 1 United Kingdom 1 United States 14 Global 99
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96187-53-0, BrequinarRelated Search:

Quinapril SODIUM 4-PYRIDINECARBOXYLATE TETRAHYDRATE 3-METHYLQUINOLINE-4-CARBOXYLIC ACID 6-Fluoroquinaldine 3-METHYL-2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID Brequinar 4-METHYL-2-P-TOLYL-PYRIDINE 2-P-TOLYL-QUINOLINE-4-CARBOXYLIC ACID 6-FLUORO-2-METHYLQUINOLINE-4-CARBOXYLIC ACID 2-BIPHENYL-4-YL-QUINOLINE-4-CARBOXYLIC ACID

  • Brequinar
  • 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid
  • 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid
  • 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl
  • 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-Methyl-
  • 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
  • Biphenquinate
  • BPQ
  • 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)
  • Brequinar (DUP785)
  • BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.
  • 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid
  • CS-157
  • NSC-368390,DHODH,Inhibitor,DUP 785,Brequinar,Virus Protease,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis,SARS coronavirus,inhibit,DUP-785,SARS-CoV,NSC368390
  • 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylicaci
  • 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
  • 96187-53-0
  • C22H13F2NO2
  • C23H15F2NO2
  • API