6-Azaindole-3-carboxaldehyde

Product Name: 6-Azaindole-3-carboxaldehyde
CAS No.: 25957-65-7
Chemical Name: 6-Azaindole-3-carboxaldehyde
Synonyms: 6-Azaindole-3-aldehyde;6-Azaindole-3-carbaldehyde;3-c]pyridine-3-carbaldehyde;6-Azazindole-3-carboxyaldehyde.;H-pyrrolo[2,3-c]pyridine-3-carbaldehyde;1H-Pyrrolo[2,3-c]pyridine-3-carboxaldehyde;1-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde (7CI)
CBNumber: CB01216033
Molecular Formula: C8H6N2O
Formula Weight: 146.15
MOL File: 25957-65-7.mol

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6-Azaindole-3-carboxaldehyde Property

Boiling point:: 383.2±22.0 °C(Predicted)
Density: 1.368
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 13.16±0.40(Predicted)
Appearance: Off-white to gray Solid
InChI: InChI=1S/C8H6N2O/c11-5-6-3-10-8-4-9-2-1-7(6)8/h1-5,10H
InChIKey: IAMJYHYPXUQXGI-UHFFFAOYSA-N
SMILES: C1=NC=CC2C(C=O)=CNC1=2
CAS DataBase Reference: 25957-65-7

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B529860
Product name: 1H-Pyrrolo[2,3-c]pyridine-3-carbaldehyde
Packaging: 100mg
Price: $40
Updated: 2021/12/16

ChemScene

Product number: CS-W009006
Product name: 6-Azaindole-3-carboxaldehyde
Purity: 99.90%
Packaging: 1g
Price: $54
Updated: 2021/12/16

Apolloscientific

Product number: OR942291
Product name: 1H-Pyrrolo[2,3-c]pyridine-3-carbaldehyde
Purity: 95%
Packaging: 250mg
Price: $145
Updated: 2021/12/16

ChemScene

Product number: CS-W009006
Product name: 6-Azaindole-3-carboxaldehyde
Purity: 99.90%
Packaging: 5g
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-W009006
Product name: 6-Azaindole-3-carboxaldehyde
Purity: 99.90%
Packaging: 10g
Price: $332
Updated: 2021/12/16

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6-Azaindole-3-carboxaldehyde Chemical Properties,Usage,Production

Uses

1H-Pyrrolo[2,3-c]pyridine-3-carbaldehyde is used in preparation of α,β-unsaturated ketone derivatives as microtubule inhibitors for treatment of tumor.

Synthesis

271-29-4

4885-02-3

25957-65-7

GENERAL STEPS: To a solution of 6-azaindole (0.400 g; 3.386 mmol) in a solvent mixture of 1,2-dichloroethane (10 mL) and nitromethane (10 mL), cooled to 0°C. A mixture of 1,1-dichlorodimethyl ether (1.544 mL; 16.92 mmol) and aluminum trichloride (1.500 g; 11.25 mmol) was slowly added dropwise under argon protection for a controlled time of 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of water and saturated sodium bicarbonate solution. The reaction mixture was extracted with a solvent mixture of dichloromethane and ethanol (9:1 v/v, 6 x 100 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford the crude product 1H-pyrrolo[2,3-c]pyridine-3-carboxaldehyde (0.295 g, 60% yield), which could be used in the subsequent reaction without further purification. Product characterization data: ESI/APCI(+) m/z: 147 ([M + H]+); ESI/APCI(-) m/z: 145 ([M - H]-). 1H NMR (DMSO-d6) δ: 10.01 (1H, s), 8.88 (1H, s), 8.50 (1H, s), 8.33 (1H, d), 8.00 (1H, d). d).

References

[1] Patent: WO2013/45516, 2013, A1. Location in patent: Page/Page column 200

6-Azaindole-3-carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Azaindole-3-carboxaldehyde Suppliers

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View Lastest Price from 6-Azaindole-3-carboxaldehyde manufacturers

Career Henan Chemical Co

Product: 6-Azaindole-3-carboxaldehyde 25957-65-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

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6-Azazindole-3-carboxyaldehyde.

6-Azaindole-3-carbaldehyde

1-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde (7CI)

1H-Pyrrolo[2,3-c]pyridine-3-carboxaldehyde

3-c]pyridine-3-carbaldehyde

6-Azaindole-3-aldehyde

H-pyrrolo[2,3-c]pyridine-3-carbaldehyde

25957-65-7