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Vardenafil hydrochloride trihydrate

Product Name
Vardenafil hydrochloride trihydrate
CAS No.
330808-88-3
Chemical Name
Vardenafil hydrochloride trihydrate
Synonyms
VARDENAFIL HYDROCHLORIDE TRIHYDRATE;Vardenafil hydrochloride CRS;Vardenafil for system suitability;Vardenafil Hydrochloride (1711010);vardenafil hydrochloride trihyrate;Verdenafil Hydrochloride Trihydrate;2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride hydrate;2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride trihydrate;2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one,hydrochloride, hydrate (1:1:3);IMidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-Methyl-7-propyl-,hydrochloride, hydrate (1:1:3)
CBNumber
CB01230855
Molecular Formula
C23H35ClN6O5S
Formula Weight
543.08
MOL File
330808-88-3.mol
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Vardenafil hydrochloride trihydrate Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
≥13.3 mg/mL in DMSO; ≥3.42 mg/mL in EtOH with gentle warming and ultrasonic; ≥95 mg/mL in H2O
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Safety

RIDADR 
UN 2811 6.1 / PGIII
HS Code 
2933595960
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001647
Product name
Vardenafil hydrochloride trihydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001647
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2720
Product name
Vardenafil Hydrochloride
Purity
certified reference material, pharmaceutical secondary standard
Packaging
500MG
Price
$253
Updated
2024/03/01
Sigma-Aldrich
Product number
1711010
Product name
Vardenafil for system suitability
Packaging
200mg
Price
$429
Updated
2024/03/01
Cayman Chemical
Product number
14930
Product name
Vardenafil (hydrochloride hydrate)
Purity
≥98%
Packaging
10mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
14930
Product name
Vardenafil (hydrochloride hydrate)
Purity
≥98%
Packaging
25mg
Price
$222
Updated
2024/03/01
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Vardenafil hydrochloride trihydrate Chemical Properties,Usage,Production

Description

Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM). It is selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively). Vardenafil (4 mg/kg per day for three weeks) improves erectile function in a rat model of acute arteriogenic erectile dysfunction by increasing intracavernous pressure and mean arterial pressure, and this effect persists for at least two weeks following the end of treatment. Chronic vardenafil administration at a dose of 2 mg/kg for five weeks in subordinate mice reduces the latency to mount and increases the frequency of mounting behavior. Formulations containing vardenafil have been used in the treatment of erectile dysfunction.

Uses

Vardenafil Hydrochloride Trihydrate (cas# 330808-88-3) has therapeutic applications and used in cosmetics and personal care products.

Uses

Vardenafil hydrochloride trihydrate is a potent inhibitor of PDE5 (IC50 = 0.2-1.2 nM) that less effectively blocks the activities of PDE6, PDE1, and PDE11 (IC50s = 2, 230, and 130 nM, respectively). PDE5 inhibitors, including vardenafil, have applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.[Cayman Chemical]

Biological Activity

Vardenafil HCl Trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.

in vitro

Vardenafil specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM (6.6 nM). Vardenafil significantly enhances the SNP-induced relaxation of human trabecular smooth muscle at 3 nM (10 nM). Vardenafil also significantly potentiates both ACh-induced and transmural electrical stimulation-induced relaxation of trabecular smooth muscle. Vardenafil (100 mM) increases cyclic GMP levels in rat hippocampal slices. Vardenafil, tadalafil, and Sildenafil each competitively inhibit cGMP hydrolysis by phosphodiesterase-5 (PDE5), thereby fostering cGMP accumulation and relaxation of vascular smooth muscle.

in vivo

Vardenafil dose-dependently potentiates erectile responses to intravenously administered sodium nitroprusside in rabbit. Vardenafil (3 mg/kg, p.o.) results in an improved object discrimination performance in rats. Vardenafil (30 mg/L, p.o.) increases both iNOS and proliferating cell nuclear antigen expression (SM cell replication) in rats, with normalization of the dynamic infusion cavernosometry drop rate and SM/collagen ratio.Vardenafil induces powerful preconditioning-like cardioprotective effect against ischemia/reperfusion injury through opening of mitochondrial K(ATP) channels in the heart of rabbit. Vardenafil protects the ischemic myocardium against reperfusion injury through a mechanism dependent on mitochondrial K(ATP) channel opening.

References

[1] saenz de tejada i1, angulo j, cuevas p, fernández a, moncada i, allona a, lledó e, körschen hg, niewöhner u, haning h, pages e, bischoff e.the phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new pde5 inhibitor vardenafil. int j impot res. 2001 oct;13(5):282-90.

Vardenafil hydrochloride trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Vardenafil hydrochloride trihydrate Suppliers

China 73 India 10 Poland 1 United Kingdom 1 United States 9 Global 94
YANCHENG JIANGZHONG CHEMICALS CO., LTD.
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0515-88981987 13365196093
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0515-88981987
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richard.li_jzchem@263.net
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Jinan Junnuo Trading Co., LTD
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13345898948
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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BOC Sciences
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1-631-485-4226; 16314854226
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United States
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Nanjing Norris-Pharm Technology Co., Ltd
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13901585132
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+86-25-52131256
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799750417@qq.com
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China
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TargetMol Chemicals Inc.
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021-33632979 15002134094
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021-33632979
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marketing@targetmol.com
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China
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3B Scientific (Wuhan) Corporation Limited
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0086-27-88063677 18186135292
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027-88063656
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sales@3bsc.com
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Bide Pharmatech Ltd.
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400-1647117 15221909166
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+86-21-61629029
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Shanghai Kewel Chemical Co., Ltd.
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021-64609169 18901607656
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021-64609160
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greensnown@163.com
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China
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Shanghai HuanChuan Industry Co.,Ltd.
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021-61478794
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021-61478794
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sales@hcshhai.com
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China
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View Lastest Price from Vardenafil hydrochloride trihydrate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE) 330808-88-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE) 330808-88-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

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