ChemicalBook > CAS DataBase List > Sanggenon C

Sanggenon C

Product Name: Sanggenon C
CAS No.: 80651-76-9
Chemical Name: Sanggenon C
Synonyms: sanggenone;Sanggenon C;Sanggenone C;Sanggenon C, 10 mM in DMSO;2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-1,3,8,10a-tetrahydroxy-5a-(3-methylbut-2-enyl)-[1]benzofuro[3,2-b]chromen-11-one;2-[(1S)-6β-(2,4-Dihydroxybenzoyl)-5α-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexene-1β-yl]-5a,10a-dihydro-1,3,8,10aβ-tetrahydroxy-5aβ-(3-methyl-2-butenyl)-11H-benzofuro[3,2-b][1]benzopyran-11-one;(5aR,10aS)-2-[6β-(2,4-Dihydroxybenzoyl)-5α-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexene-1β-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-butenyl)-11H-benzofuro[3,2-b][1]benzopyran-11-one;(5aR,10aS)-2-[(1S,5S,6R)-6-(2,4-Dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-11H-benzofuro[3,2-b][1]benzopyran-11-one;11H-Benzofuro[3,2-b][1]benzopyran-11-one, 2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-, (5aR,10aS)-;(5aR,10aS)-2-((1S,2R,3S)-2-(2,4-Dihydroxybenzoyl)-2',4'-dihydroxy-5-methyl-1,2,3,6-tetrahydro-[1,1'-biphenyl]-3-yl)-1,3,8,10a-tetrahydroxy-5a-(3-methylbut-2-en-1-yl)-5a,10a-dihydro-11H-benzofuro[3,2-b]chromen-11-one
CBNumber: CB01252426
Molecular Formula: C40H36O12
Formula Weight: 708.71
MOL File: 80651-76-9.mol

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Sanggenon C Property

Melting point:: > 240°C (dec.)
Boiling point:: 995.5±65.0 °C(Predicted)
Density: 1.512
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Acetone (Slightly), Methanol (Slightly)
pka: 6.61±0.60(Predicted)
form: Solid
color: Yellow
InChIKey: XETHJOZXBVWLLM-HUKCQOFTSA-N
SMILES: [C@@]12(C/C=C(/C)\C)C3=CC=C(O)C=C3O[C@]1(O)C(=O)C1=C(O)C([C@@H]3[C@H](C(=O)C4=CC=C(O)C=C4O)[C@@H](C4=CC=C(O)C=C4O)CC(C)=C3)=C(O)C=C1O2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30061
Product name: Sanggenone C
Packaging: 1mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 30061
Product name: Sanggenone C
Packaging: 10mg
Price: $923
Updated: 2024/03/01

Cayman Chemical

Product number: 30061
Product name: Sanggenone C
Packaging: 5mg
Price: $521
Updated: 2024/03/01

TRC

Product number: S112545
Product name: SanggenoneC
Packaging: 2.5mg
Price: $220
Updated: 2021/12/16

Usbiological

Product number: 300919
Product name: Sanggenon C
Packaging: 20mg
Price: $623
Updated: 2021/12/16

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Sanggenon C Chemical Properties,Usage,Production

Description

Sanggenone C is a flavonoid that has been found in mulberry bark and has diverse biological activities. It inhibits TNF-α- or IL-1β-induced polymorphonuclear leukocyte (PMN) adhesion to human synovial cells (HSCs; IC₅₀s = 27.29 and 54.43 nM, respectively), as well as inhibits NF-κB activation in HSCs. Sanggenone C induces apoptosis and production of reactive oxygen species (ROS) in HT-29 cells when used at concentrations ranging from 10 to 40 μM. It decreases cell viability of HT-29 cells in vitro and reduces tumor growth in an HT-29 mouse xenograft model when administered at a dose of 10 mg/kg. Sanggenone C increases vertebrate column bone mineralization in a zebrafish model of prednisone-induced osteoporosis. It also attenuates cardiac hypertrophy and fibrosis and reduces activation of nuclear factor of activated T cells 2 (NFAT2) in a mouse model of pressure overload-induced cardiac hypertrophy.

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Morus alba bark.

Uses

Sanggenone C is a flavanone isolated from Morus plant that showed cytotoxicity against human oral tumor cell lines (HSC-2 and HSG). Sanggenone C is also an inhibitor of protein tyrosine phosphatase 1B.

Definition

ChEBI: Sanggenon C is a diarylheptanoid.

in vivo

Sanggenon C (10, 20 mg/kg/day; Intraperitoneally; for 3 weeks) improves impaired cardiac function following aortic banding (AB). Sanggenon C protects against cardiac hypertrophy^[1].
Sanggenon C (10, 20 mg/kg/day; Intraperitoneally; for 21 days) suppresses the tumor burden in the nude mice bearing tumor xenografts derived from AGS. Sanggenon C downregulates levels of p-ERK expression^[2].

Animal Model:	Male C57/BL6 mice (weight 23.5-27.5 g; age, 8 weeks)^[1]
Dosage:	10, 20 mg/kg
Administration:	Intraperitoneally; daily; for 3 weeks
Result:	Prevented the development of ventricular dysfunction, as evidenced by decreased LV end-diastolic diameter, LV end-systolic diameter, and increased LVFS and LVEF.

target

NF-kB | NO | NOS | IkB | IKK

IC 50

NF-κB; ERK

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] LI-DONG CHEN. Sanggenon C induces apoptosis of colon cancer cells via inhibition of NO production, iNOS expression and ROS activation of the mitochondrial pathway.[J]. Oncology reports, 2017: 2123-2131. DOI: 10.3892/or.2017.5912
[3] HUIJUAN WANG. Sanggenon C Stimulates Osteoblastic Proliferation and Differentiation, Inhibits Osteoclastic Resorption, and Ameliorates Prednisone-Induced Osteoporosis in Zebrafish Model.[J]. Molecules, 2018. DOI: 10.3390/molecules23092343
[4] LILI XIAO. Sanggenon C protects against pressure overload?induced cardiac hypertrophy via the calcineurin/NFAT2 pathway.[J]. Molecular medicine reports, 2017: 5338-5346. DOI: 10.3892/mmr.2017.7288

Sanggenon C Preparation Products And Raw materials

Raw materials

Preparation Products

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Sanggenon C Suppliers

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View Lastest Price from Sanggenon C manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Sanggenon C 80651-76-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-09-01

Shanghai Standard Technology Co., Ltd.

Product: Sanggenon C 80651-76-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-12

Career Henan Chemical Co

Product: Sanggenon C 80651-76-9
Price: US $100.00/KG
Min. Order: 1KG
Purity: 97%
Supply Ability: customise
Release date: 2018-07-26

80651-76-9, Sanggenon CRelated Search:

Mulberroside B Sanggenol P 3-N-OXALYL-L-2,3-DIAMINOPROPANOICACID Cornuside Alpinetin KAEMPFEROL-3-O-RUTINOSIDE SHANZHISIDE METHYL ESTER spicatosideB Complanatoside A Maslinic acid SAUCHINONE 7,8-Dihydroxycoumarin ARTEMISININ MORIN Cephalomannine Notoginsenoside R1 kuwanon H mulberrofuran G

sanggenone

Sanggenon C

(5aR,10aS)-2-[6β-(2,4-Dihydroxybenzoyl)-5α-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexene-1β-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-butenyl)-11H-benzofuro[3,2-b][1]benzopyran-11-one

2-[(1S)-6β-(2,4-Dihydroxybenzoyl)-5α-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexene-1β-yl]-5a,10a-dihydro-1,3,8,10aβ-tetrahydroxy-5aβ-(3-methyl-2-butenyl)-11H-benzofuro[3,2-b][1]benzopyran-11-one

Sanggenone C

(5aR,10aS)-2-[(1S,5S,6R)-6-(2,4-Dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-11H-benzofuro[3,2-b][1]benzopyran-11-one

11H-Benzofuro[3,2-b][1]benzopyran-11-one, 2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-, (5aR,10aS)-

(5aR,10aS)-2-((1S,2R,3S)-2-(2,4-Dihydroxybenzoyl)-2',4'-dihydroxy-5-methyl-1,2,3,6-tetrahydro-[1,1'-biphenyl]-3-yl)-1,3,8,10a-tetrahydroxy-5a-(3-methylbut-2-en-1-yl)-5a,10a-dihydro-11H-benzofuro[3,2-b]chromen-11-one

2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-1,3,8,10a-tetrahydroxy-5a-(3-methylbut-2-enyl)-[1]benzofuro[3,2-b]chromen-11-one

Sanggenon C, 10 mM in DMSO

80651-76-9

C40H36O12

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

reagent

standard substance

chemical reagent

pharmaceutical intermediate