ChemicalBook > CAS DataBase List > 15-KETO PROSTAGLANDIN E2

15-KETO PROSTAGLANDIN E2

Product Name
15-KETO PROSTAGLANDIN E2
CAS No.
26441-05-4
Chemical Name
15-KETO PROSTAGLANDIN E2
Synonyms
15-KetoPGE2;15-Oxoprostaglandin E2;15-KETO PROSTAGLANDIN E2;15-Dehydroprostaglandin E2;Dinoprostone EP Impurity F;15-keto Prostaglandin E2 MaxSpecStandard;Alprostadil (Prostaglandin E1) Impurity 6;15-keto Prostaglandin E2 Lipid Maps MS Standard;9,15-DIOXO-11ALPHA-HYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;(5Z,13E)-9,15-Dioxo-11α-hydroxyprosta-5,13-diene-1-oic acid
CBNumber
CB0125323
Molecular Formula
C20H30O5
Formula Weight
350.45
MOL File
26441-05-4.mol
More
Less

15-KETO PROSTAGLANDIN E2 Property

Boiling point:
534.4±50.0 °C(Predicted)
Density 
1.144±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2)
form 
A crystalline solid
pka
4.75±0.10(Predicted)
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
14720
Product name
15-keto Prostaglandin E2
Purity
≥98%
Packaging
500μg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
10007215
Product name
15-keto Prostaglandin E2 MaxSpec? Standard
Purity
≥95%
Packaging
100μg
Price
$106
Updated
2023/06/20
Cayman Chemical
Product number
14720
Product name
15-keto Prostaglandin E2
Purity
≥98%
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
14720
Product name
15-keto Prostaglandin E2
Purity
≥98%
Packaging
5mg
Price
$505
Updated
2024/03/01
Cayman Chemical
Product number
14720
Product name
15-keto Prostaglandin E2
Purity
≥98%
Packaging
10mg
Price
$884
Updated
2024/03/01
More
Less

15-KETO PROSTAGLANDIN E2 Chemical Properties,Usage,Production

Description

15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Item Nos. 14010) formed by 15-hydroxy prostaglandin dehydrogenase (15-PGDH). Unlike PGE2, 15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 2.6 and 15 μM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = 1.8 and >33 μM, respectively). However, it does bind to EP2 and EP4 in HEK cells expressing these receptors (IC50s = 0.117 and 2.82 μM, respectively), as well as induces cAMP formation (EC50s = 0.137 and 0.426 μM, respectively) and the transcriptional activity of β-catenin/TCF in the same cells. 15-keto PGE2 inhibits CD3-CD28-MHC-I-induced proliferation of isolated human CD4+ T cells in a concentration-dependent manner. It also reduces mortality in a mouse model of LPS-induced sepsis when administered at a dose of 15 mg/kg.

15-keto PGE2 MaxSpec® standard is a quantitative grade standard of 15-keto PGE2 that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 15-keto PGE2 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 formed by 15-hydroxy PGDH. In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).[Cayman Chemical]

Uses

15-Keto Prostaglandin E2 is a lipid compound derived from arachidonic acid by the action of cyclooxygenases. Prostaglandins act locally as messenger molecules in a variety of physiological processes.

Definition

ChEBI: 15-dehydro-prostaglandin E2 is a prostaglandins E. It is functionally related to a prostaglandin E2. It is a conjugate acid of a 15-dehydro-prostaglandin E2(1-).

15-KETO PROSTAGLANDIN E2 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

15-KETO PROSTAGLANDIN E2 Suppliers

China 21 France 1 Germany 1 India 4 Switzerland 2 United Kingdom 1 United States 7 Global 37
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd
Tel
0571-85361029
Fax
0571-85361029
Email
synstar518@163.com
Country
China
ProdList
1990
Advantage
58
Finetech Industry Limited
Tel
+86-27-87465837 +8618971612321
Fax
86 27 87772287
Email
info@finetechnology-ind.com
Country
China
ProdList
9639
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44808
Advantage
58
Zhuhai Anzhe Biotechnology Co,Ltd.
Tel
13169972583
Email
513211116@qq.com
Country
China
ProdList
3006
Advantage
58
Changzhou Xianglong Pharmaceutical Technology Co., LTD
Tel
18661161657
Email
yaoxiangqiu2021@163.com
Country
China
ProdList
9996
Advantage
58
Hubei Kele Fine Chemical Co., Ltd
Tel
027-59101668 19945030958
Fax
027-59101668
Email
2881924765@qq.com
Country
China
ProdList
8126
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62163
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Hubei Aiputi Bioengineering Co., Ltd.
Tel
17762444226
Email
d17762444226@163.com
Country
China
ProdList
2402
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4933
Advantage
58
Shanghai AMINO Biotechnology Co., Ltd
Tel
17302153218
Email
1743952078@qq.com
Country
China
ProdList
706
Advantage
58
Shanghai Zerui Biotechnology Co., Ltd.
Tel
021-54580889 18321124657
Fax
021-54580889
Email
731997554@qq.com
Country
China
ProdList
10608
Advantage
58
Nantong Hanfang Biotechnology Co. , Ltd.
Tel
18616537568
Email
hanfangpharma@126.com
Country
China
ProdList
30961
Advantage
58
Wuhan Topule Biopharmaceutical Co., Ltd
Tel
+8618327326525
Email
masar@topule.com
Country
China
ProdList
8467
Advantage
58
Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

26441-05-4, 15-KETO PROSTAGLANDIN E2Related Search:

13,14-DIHYDRO-15-KETO PROSTAGLANDIN A2 13,14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER 13,14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA 15-KETO PROSTAGLANDIN F2ALPHA 15-KETO PROSTAGLANDIN E2 11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 15-KETO PROSTAGLANDIN E1 13,14-DIHYDRO-15-KETO PROSTAGLANDIN F1ALPHA 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA 15-KETO PROSTAGLANDIN F1ALPHA 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1-D4 15-KETO PROSTAGLANDIN E2 LIPID MAPS 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 LIPID MAPS 13,14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA LIPID MAPS 15-KETO PROSTAGLANDIN F2ALPHA LIPID MAPS

  • (E)-7-[(1R,2S,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid
  • 11-Hydroxy-9,15-dioxo-[5Z,11α,13E]-prosta-5,13-dien-1-oic acid: 15-Dehydroprostaglandin E2
  • (5Z,11R,13E)-11-Hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid
  • (5Z,13E)-11α-Hydroxy-9,15-dioxo-5,13-prostadiene-1-oic acid
  • (5Z,13E)-9,15-Dioxo-11α-hydroxyprosta-5,13-diene-1-oic acid
  • 15-KetoPGE2
  • 15-Oxoprostaglandin E2
  • 15-keto Prostaglandin E2 Lipid Maps MS Standard
  • 11-Hydroxy-9,15-dioxo-[5Z,11α,13E]-prosta-5,13-dien-1-oic acid
  • 15-Dehydroprostaglandin E2
  • 15-keto Prostaglandin E2 MaxSpecStandard
  • 15-KETO PROSTAGLANDIN E2
  • 9,15-DIOXO-11ALPHA-HYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID
  • Prosta-5,13-dien-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,11α,13E)-
  • Dinoprostone EP Impurity F
  • (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E)-3-oxo-oct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid (15-oxo-PGE2
  • Alprostadil (Prostaglandin E1) Impurity 6
  • Prosta-5,13-dien-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,11α,13E)-
  • (Z)-7-((1R,2R,3R)-3-Hydroxy-5-oxo-2-((E)-3-oxooct-1-en-1-yl)cyclopentyl)hept-5-enoic acid
  • 26441-05-4