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15-KETO PROSTAGLANDIN E2

Product Name
15-KETO PROSTAGLANDIN E2
CAS No.
26441-05-4
Chemical Name
15-KETO PROSTAGLANDIN E2
Synonyms
15-KetoPGE2;15-Oxoprostaglandin E2;15-KETO PROSTAGLANDIN E2;15-Dehydroprostaglandin E2;Dinoprostone EP Impurity F;15-keto Prostaglandin E2 MaxSpecStandard;Alprostadil (Prostaglandin E1) Impurity 6;15-keto Prostaglandin E2 Lipid Maps MS Standard;9,15-DIOXO-11ALPHA-HYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;(5Z,13E)-9,15-Dioxo-11α-hydroxyprosta-5,13-diene-1-oic acid
CBNumber
CB0125323
Molecular Formula
C20H30O5
Formula Weight
350.45
MOL File
26441-05-4.mol
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15-KETO PROSTAGLANDIN E2 Property

Boiling point:
534.4±50.0 °C(Predicted)
Density 
1.144±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2)
form 
A crystalline solid
pka
4.75±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

Cayman Chemical
Product number
14720
Product name
15-keto Prostaglandin E2
Purity
≥98%
Packaging
500μg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
10007215
Product name
15-keto Prostaglandin E2 MaxSpec? Standard
Purity
≥95%
Packaging
100μg
Price
$106
Updated
2023/06/20
Cayman Chemical
Product number
14720
Product name
15-keto Prostaglandin E2
Purity
≥98%
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
14720
Product name
15-keto Prostaglandin E2
Purity
≥98%
Packaging
5mg
Price
$505
Updated
2024/03/01
Cayman Chemical
Product number
14720
Product name
15-keto Prostaglandin E2
Purity
≥98%
Packaging
10mg
Price
$884
Updated
2024/03/01
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15-KETO PROSTAGLANDIN E2 Chemical Properties,Usage,Production

Description

15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Item Nos. 14010) formed by 15-hydroxy prostaglandin dehydrogenase (15-PGDH). Unlike PGE2, 15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 2.6 and 15 μM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = 1.8 and >33 μM, respectively). However, it does bind to EP2 and EP4 in HEK cells expressing these receptors (IC50s = 0.117 and 2.82 μM, respectively), as well as induces cAMP formation (EC50s = 0.137 and 0.426 μM, respectively) and the transcriptional activity of β-catenin/TCF in the same cells. 15-keto PGE2 inhibits CD3-CD28-MHC-I-induced proliferation of isolated human CD4+ T cells in a concentration-dependent manner. It also reduces mortality in a mouse model of LPS-induced sepsis when administered at a dose of 15 mg/kg.

15-keto PGE2 MaxSpec® standard is a quantitative grade standard of 15-keto PGE2 that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 15-keto PGE2 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 formed by 15-hydroxy PGDH. In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).[Cayman Chemical]

Uses

15-Keto Prostaglandin E2 is a lipid compound derived from arachidonic acid by the action of cyclooxygenases. Prostaglandins act locally as messenger molecules in a variety of physiological processes.

Definition

ChEBI: 15-dehydro-prostaglandin E2 is a prostaglandins E. It is functionally related to a prostaglandin E2. It is a conjugate acid of a 15-dehydro-prostaglandin E2(1-).

15-KETO PROSTAGLANDIN E2 Preparation Products And Raw materials

Raw materials

Preparation Products

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15-KETO PROSTAGLANDIN E2 Suppliers

China 16 France 1 Germany 1 India 4 Switzerland 2 United Kingdom 1 United States 6 Global 31
ChemStrong Scientific Co.,Ltd
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0755-0755-66853366 13670046396
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0755-28363542
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sales@chem-strong.com
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China
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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sales@glpbio.cn
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China
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6870
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58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd
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0571-85361029
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0571-85361029
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synstar518@163.com
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China
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1991
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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11289
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58
Energy Chemical
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021-58432009 400-005-6266
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021-58436166
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marketing1@energy-chemical.com
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China
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44843
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58
Zhuhai Anzhe Biotechnology Co,Ltd.
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13169972583
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513211116@qq.com
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3015
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Changzhou Xianglong Pharmaceutical Technology Co., LTD
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0519-88910898 18661161657
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China
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10066
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Hubei Kele Fine Chemical Co., Ltd
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027-59101668 19945030958
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027-59101668
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2881924765@qq.com
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China
ProdList
7973
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58
Hubei Aiputi Bioengineering Co., Ltd.
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17762444226
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d17762444226@163.com
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China
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Nantong QuanYi Biotechnology Co., Ltd
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0513-66337626 18051384581
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sales@chemhifuture.com
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com
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8740
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Shanghai Zerui Biotechnology Co., Ltd.
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021-54580889 18321124657
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021-54580889
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731997554@qq.com
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China
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Nantong Hanfang Biotechnology Co. , Ltd.
Tel
3674309880
Email
hanfangpharma@126.com
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China
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30968
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Wuhan Topule Biopharmaceutical Co., Ltd
Tel
+8618327326525
Email
masar@topule.com
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8474
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Hangzhou MolCore BioPharmatech Co.,Ltd.
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+86-057181025280; +8617767106207
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49739
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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--
Fax
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info@zzsrm.com
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CHINA
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26441-05-4, 15-KETO PROSTAGLANDIN E2Related Search:

13,14-DIHYDRO-15-KETO PROSTAGLANDIN A2 13,14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER 13,14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA 15-KETO PROSTAGLANDIN F2ALPHA 15-KETO PROSTAGLANDIN E2 11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 15-KETO PROSTAGLANDIN E1 13,14-DIHYDRO-15-KETO PROSTAGLANDIN F1ALPHA 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA 15-KETO PROSTAGLANDIN F1ALPHA 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1-D4 15-KETO PROSTAGLANDIN E2 LIPID MAPS 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 LIPID MAPS 13,14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA LIPID MAPS 15-KETO PROSTAGLANDIN F2ALPHA LIPID MAPS

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