13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2
- Product Name
- 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2
- CAS No.
- 363-23-5
- Chemical Name
- 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2
- Synonyms
- PGEM;13,14-Dihydro-15-keto-PGE2;CUJMXIQZWPZMNQ-XYYGWQPLSA-N;15-keto-13,14-dihydroprostaglandine2;13,14-dihydro-15-oxo-prostaglandin E2;13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2;13,14-Dihydro-15-ketoprostaglandinE2 solution;9,15-DIOXO-11ALPHA-HYDROXY-PROST-5Z-EN-1-OIC ACID;(5Z)-11α-Hydroxy-9,15-dioxoprosta-5-ene-1-oic acid;(5Z,11α)-11-Hydroxy-9,15-dioxoprost-5-en-1-oic acid
- CBNumber
- CB8349316
- Molecular Formula
- C20H32O5
- Formula Weight
- 352.47
- MOL File
- 363-23-5.mol
13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2 Property
- Boiling point:
- 538.1±45.0 °C(Predicted)
- Density
- 1.086±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMF: >100 mg/ml
DMSO: >100 mg/ml
Ethanol: >100 mg/mlPBS (pH 7.2): >5 mg/ml - form
- Liquid
- pka
- 4.75±0.10(Predicted)
- color
- Colorless to light yellow
Safety
- Hazard Codes
- F,Xn,Xi
- Risk Statements
- 11-20/21/22-36/37/38-67-66-36
- Safety Statements
- 16-26-36
- RIDADR
- UN 1231 3/PG 2
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H351Suspected of causing cancer
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 14650
- Product name
- 13,14-dihydro-15-keto Prostaglandin E2
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 14650
- Product name
- 13,14-dihydro-15-keto Prostaglandin E2
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $340
- Updated
- 2024/03/01
- Product number
- 14650
- Product name
- 13,14-dihydro-15-keto Prostaglandin E2
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $602
- Updated
- 2024/03/01
- Product number
- 10007214
- Product name
- 13,14-dihydro-15-keto Prostaglandin E2 MaxSpec? Standard
- Purity
- >95%
- Packaging
- 100μg
- Price
- $118
- Updated
- 2023/06/20
13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2 Chemical Properties,Usage,Production
Description
13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) is a metabolite of PGE2 and the primary PGE2 metabolite in plasma. It is formed from PGE2 via a 15-keto PGE2 intermediate by 15-oxo-PG Δ13 reductase. Unlike PGE2, 13,14-dihydro-15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 12 and 57 μM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = >18 and >38 μM, respectively). Levels of 13,14-dihydro-15-keto PGE2 are increased in the plasma of women in the third trimester of pregnancy and in women during and immediately after labor and delivery. Levels of 13,14-dihydro-15-keto PGE2 levels are decreased in tumor tissue compared to adjacent non-cancerous tissue isolated from patients with non-small cell lung cancer (NSCLC).
Uses
13,14-Dihydro-15-ketoPGE2 is a primary metabolite of PGE2 in plasma.
Definition
ChEBI: The 13,14-dihydro derivative of 15-oxo-prostaglandin E2.
References
[1] P. HUSSLEIN H. S. Concentration of 13,14-dihydro-15-keto-prostaglandin E2 in the maternal peripheral plasma during labour of spontaneous onset[J]. Bjog-An International Journal of Obstetrics and Gynaecology, 1984, 91 3: 228-231. DOI: 10.1111/j.1471-0528.1984.tb04757.x
[2] DUNCAN HUGHES. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer.[J]. Cancer prevention research (Philadelphia, Pa.), 2008, 1 4: 241-249. DOI: 10.1158/1940-6207.capr-08-0055
[3] JOVANA MARIC PHD , PHD Gerd G M Nerea Ferreirós PhD, PHD Danielle F M, et al. Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation[J]. Journal of Allergy and Clinical Immunology, 2019, 143 6: Pages 2202-2214.e5. DOI: 10.1016/j.jaci.2018.10.069
[4] M. HAMBERG B S. On the Metabolism of Prostaglandins E1 and E2 in Man[J]. Journal of Biological Chemistry, 1971, 246 1: 6713-6721. DOI: 10.1016/s0021-9258(19)45905-x
[5] N. NISHIGAKI A I M Negishi. Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist.[J]. Molecular Pharmacology, 1996, 146 1: 1031-1037. DOI: 10.1254/fpj.108.supplement_65
[6] DAVID MERIWETHER. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model.[J]. Journal of Clinical Investigation, 2019, 129 9: 3670-3685. DOI: 10.1172/jci123700
13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2 Preparation Products And Raw materials
Raw materials
Preparation Products
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