DEFEROXAMINE MESYLATE

Product Name: DEFEROXAMINE MESYLATE
CAS No.: 138-14-7
Chemical Name: DEFEROXAMINE MESYLATE
Synonyms: DFOM;desferal;DESFERRIOXAMINE MESYLATE;deferoxaminebmesylate;Desferioxamine mesylate;desferrioxamine mesilate;DEFEROXAMINE MESYLATE SALT;Prestwick_988;desferalmesylate;deferoxaminemesilate
CBNumber: CB4372020
Molecular Formula: C26H52N6O11S
Formula Weight: 656.79
MOL File: 138-14-7.mol

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DEFEROXAMINE MESYLATE Property

Melting point:: 148-149°
storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL
form: powder
color: white to off-white
Water Solubility: Soluble to 100 mM in water

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Safety

Safety Statements: 22-24/25
WGK Germany: 2
RTECS: UG5310000
HS Code: 29280000
Toxicity: man,TDLo,parenteral,16gm/kg/34W-I (16000mg/kg),CARDIAC: PERICARDITISGASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINEBLOOD: OTHER CHANGES,American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D9533
Product name: Deferoxamine mesylate salt
Purity: powder, ≥92.5% (TLC)
Packaging: 1g
Price: $142
Updated: 2024/03/01

Sigma-Aldrich

Product number: 252750
Product name: Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem
Purity: Parenteralironchelatingagent.Commonlyusedintherapyasachelatorofferri
Packaging: 1g
Price: $210
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1166003
Product name: Deferoxamine mesylate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 300mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001934
Product name: Deferoxamine for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0001934
Price: $218
Updated: 2023/06/20

Cayman Chemical

Product number: 14595
Product name: Deferoxamine (mesylate)
Purity: ≥95%
Packaging: 500mg
Price: $73
Updated: 2024/03/01

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DEFEROXAMINE MESYLATE Chemical Properties,Usage,Production

Description

Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC₅₀ = 17.8 μM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia. Deferoxamine has applications in diseases that are characterized by high levels of circulating iron, such as thalassemia major.

Chemical Properties

DEFEROXAMINE MESYLATE is white or almost white powder.

Uses

chelating agent (Fe & Al)

Uses

DEFEROXAMINE MESYLATE is an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients

brand name

Desferal (Novartis).

Biochem/physiol Actions

An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.

Clinical Use

Chelating agent:
Acute iron poisoning
Chronic iron or aluminium overload

Veterinary Drugs and Treatments

Deferoxamine is used for the treatment of either acute or chronic iron toxicity. It is being evaluated as an iron chelator for adjunctive treatment of acute cardiac ischemia and as a chelator for aluminum toxicity. Its efficacy in treating reperfusion injuries has been disappointing.

Drug interactions

Potentially hazardous interactions with other drugs
Avoid prochlorperazine, levomepromazine and methotrimeprazine (prolonged unconsciousness).
Do not administer with blood.

Metabolism

When given parenterally desferrioxamine forms chelates with iron and aluminium ions to form ferrioxamine and aluminoxamine, respectively. The chelates are excreted in the urine and faeces via the bile. Desferrioxamine is metabolised, mainly in the plasma. Four metabolites of desferrioxamine were isolated from urine of patients with iron overload. The following biotransformation reactions were found to occur with desferrioxamine: transamination and oxidation yielding an acid metabolite, beta-oxidation also yielding an acid metabolite, decarboxylation and N-hydroxylation yielding neutral metabolites.

storage

Store at -20°C

DEFEROXAMINE MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DEFEROXAMINE MESYLATE Suppliers

Brazil 1 Canada 1 China 126 Czech Republic 1 Europe 1 France 3 Germany 4 India 6 Israel 2 Japan 1 Poland 1 South Korea 1 Spain 1 Switzerland 3 United Kingdom 14 United States 32 Global 198

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7815
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: +8618575662672 18575662672
Fax: 021 51613951
Email: mzeng@3wpharm.com
Country: China
ProdList: 10053
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4550
Advantage: 62

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4941
Advantage: 60

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9901
Advantage: 58

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View Lastest Price from DEFEROXAMINE MESYLATE manufacturers

Henan Fengda Chemical Co., Ltd

Product: DEFEROXAMINE MESYLATE 138-14-7
Price: US $8.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-24

Honest Joy Holdings Limited

Product: DeferoxaMine Mesylate 138-14-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.4%
Supply Ability: 100 tons
Release date: 2022-02-18

Dideu Industries Group Limited

Product: DEFEROXAMINE MESYLATE 138-14-7
Price: US $1.10/g
Min. Order: 1g
Purity: 0.999
Supply Ability: 100 Tons min
Release date: 2021-08-13

138-14-7, DEFEROXAMINE MESYLATERelated Search:

Hydroxyurea Deferoxamine AMMONIUM FERRIC CHLORIDE Ammonium ferric sulfate dodecahydrate Ferric ammonium EDTA Ferrous ammonium sulfate hexahydrate AMMONIUM IRON (III) HEXACYANOFERRATE (II) Ferric ammonium citrate,brown Ammonium iron(III) sulfate Ferric ammonium oxalate MAFA Ammonium ferric citrate Ferric ammonium oxalate trihydrate DEFEROXAMINE MESYLATE NOCARDAMINE ferrimycin A1 MAFA aqueous solution (5%) Deferoxamine Mesylate Salt

deferoxaminebmesylate

deferoxaminemesilate

deferoxaminemethanesulfonate

desferal

desferalmesylate

desferalmethanesulfonate

desferrioxaminebmesylate

Deferoxamine Mesylate (300 mg)

N-[5-[3-[(5-aMinopentyl)hydroxycarbaMoyl]propionaMido]pentyl]-3-[[5-(N-hydroxyacetaMido)

N1-(5-aMinopentyl)-N1-hydroxy-N4-[5-[[4-[[5-(acetylhydroxyaMino)pentyl]aMino]-1,4-dioxobutyl]hydroxyaMino]pentyl]butanediaMide Methanesulfonate

desferrioxaminebmethanesulfonate

monomethanesulfonate(sa

propionohydroxamicacid,n-(5-(3-((5-aminopentyl)hydroxycarbamoyl)propionamido)

Butanediamide, N-5-4-5-(acetylhydroxyamino)pentylamino-1,4-dioxobutylhydroxyaminopentyl-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate (salt)

STARCHDEFEROXAMINECONJUGATE

Desferrioxamine mesylate salt

Prestwick_988

Deferoxamine mesylate salt,DFOM, Deferoxamine methanesulfonate salt, Desferrioxamine mesylate salt

Deferoxamine Mesylate (500 mg)

DFOM

DESFERRIOXAMINE MESYLATE

DEFEROXAMINE MESYLATE

DEFEROXAMINE MESYLATE SALT

DEFEROXAMINE METHANESULFONATE SALT

N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxybutanediamide methanesulfonate

Desferioxamine mesylate

Deferoxamine Mesilate RS

desferrioxamine mesilate

Deferoxamine mesilate CRS

Deferoxamine for system suitability

DEFEROXAMINE MESYLATE USP/EP/BP

Deferoxamine Mesylate (1166003)

esferrioxamineBmesylate

N1-(5-(4-((5-Aminopentyl)amino)-4-oxobutanamido)pentyl)-N1-hydroxy-N4-(5-(N-hydroxyacetamido)pentyl)succinamide methanesulfonate

HIFs,neovascularization,TAMSCs,diabetes mellitus,Akt,PKB,Protein kinase B,Apoptosis,Autophagy,SH-SY5Y,Hypoxia-inducible factors,Deferoxamine,Deferoxamine Mesylate,Inhibitor,MEFs,cancer,Alzheimer’s disease,HIF-PH,Reactive Oxygen Species,BMMSCs,inhibit,HIF/HIF Prolyl-Hydroxylase,COVID-19

Deferiprone Impurity 3

Deferoxamine mesylate USP/Ph. Eur

138-14-7

C26H52N6O11S

C25H48N6O8CH4O3S

C25H48N6O8CH4SO3

Inhibitors

DESFERAL

Pharmaceuticals

Aliphatics

Amines

Chelating Agents & Ligands

Intermediates & Fine Chemicals