ChemicalBook > CAS DataBase List > DEFEROXAMINE MESYLATE

DEFEROXAMINE MESYLATE

Product Name: DEFEROXAMINE MESYLATE
CAS No.: 138-14-7
Chemical Name: DEFEROXAMINE MESYLATE
Synonyms: DFOM;desferal;DESFERRIOXAMINE MESYLATE;deferoxaminebmesylate;Desferioxamine mesylate;desferrioxamine mesilate;DEFEROXAMINE MESYLATE SALT;Prestwick_988;desferalmesylate;deferoxaminemesilate
CBNumber: CB4372020
Molecular Formula: C26H52N6O11S
Formula Weight: 656.79
MOL File: 138-14-7.mol

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DEFEROXAMINE MESYLATE Property

Melting point:: 148-149°
storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL
form: powder
color: white to off-white
Water Solubility: Soluble to 100 mM in water
InChIKey: IDDIJAWJANBQLJ-UHFFFAOYSA-N
SMILES: C(=O)(N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN)CCC(=O)NCCCCCN(O)C(=O)C.S(=O)(=O)(O)C

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Safety

Safety Statements: 22-24/25
WGK Germany: 2
RTECS: UG5310000
HS Code: 29280000
Toxicity: man,TDLo,parenteral,16gm/kg/34W-I (16000mg/kg),CARDIAC: PERICARDITISGASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINEBLOOD: OTHER CHANGES,American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001934
Product name: Deferoxamine for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $225
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR3411
Product name: Deferoxamine Mesylate
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 500 mg
Price: $245
Updated: 2025/07/31

Sigma-Aldrich

Product number: D9533
Product name: Deferoxamine mesylate salt
Purity: powder, ≥92.5% (TLC)
Packaging: 1g
Price: $138.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: D0160000
Product name: Deferoxamine mesylate salt
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 30 mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: 252750
Product name: Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem
Purity: Parenteralironchelatingagent.Commonlyusedintherapyasachelatorofferri
Packaging: 1g
Price: $204
Updated: 2025/07/31

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DEFEROXAMINE MESYLATE Chemical Properties,Usage,Production

Description

Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC₅₀ = 17.8 μM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia. Deferoxamine has applications in diseases that are characterized by high levels of circulating iron, such as thalassemia major.

Chemical Properties

DEFEROXAMINE MESYLATE is white or almost white powder.

Uses

chelating agent (Fe & Al)

Uses

DEFEROXAMINE MESYLATE is an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients

brand name

Desferal (Novartis).

reaction suitability

reagent type: chelator

Biochem/physiol Actions

An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.

Clinical Use

Chelating agent:
Acute iron poisoning
Chronic iron or aluminium overload

Veterinary Drugs and Treatments

Deferoxamine is used for the treatment of either acute or chronic iron toxicity. It is being evaluated as an iron chelator for adjunctive treatment of acute cardiac ischemia and as a chelator for aluminum toxicity. Its efficacy in treating reperfusion injuries has been disappointing.

Drug interactions

Potentially hazardous interactions with other drugs
Avoid prochlorperazine, levomepromazine and methotrimeprazine (prolonged unconsciousness).
Do not administer with blood.

Metabolism

When given parenterally desferrioxamine forms chelates with iron and aluminium ions to form ferrioxamine and aluminoxamine, respectively. The chelates are excreted in the urine and faeces via the bile. Desferrioxamine is metabolised, mainly in the plasma. Four metabolites of desferrioxamine were isolated from urine of patients with iron overload. The following biotransformation reactions were found to occur with desferrioxamine: transamination and oxidation yielding an acid metabolite, beta-oxidation also yielding an acid metabolite, decarboxylation and N-hydroxylation yielding neutral metabolites.

storage

Store at -20°C

References

[1] W L STEINMETZ T O O M R Glick. Modified aca method for determination of iron chelated by deferoxamine and other chelators.[J]. Clinical chemistry, 1980, 26 11: 1593-1597.
[2] JIMMY R. THERIAULT . Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathway[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22 1: Pages 76-81. DOI: 10.1016/j.bmcl.2011.11.077
[3] PANU JAAKKOLA. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation[J]. Science, 2001, 292 5516. DOI: 10.1126/science.1059796
[4] K. SANDAU. Regulation of the Hypoxia-inducible Factor 1α by the Inflammatory Mediators Nitric Oxide and Tumor Necrosis Factor-α in Contrast to Desferroxamine and Phenylarsine Oxide*[J]. The Journal of Biological Chemistry, 2001, 120 1: 39805-39811. DOI: 10.1074/jbc.m107689200
[5] NEUFELD E J. Update on iron chelators in thalassemia.[J]. Hematology. American Society of Hematology. Education Program, 2010: 451-455. DOI: 10.1182/asheducation-2010.1.451
[6] JOSEPH M. HENDRICKS. Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis[J]. bioRxiv?: the preprint server for biology, 2022, 6 1. DOI: 10.1101/2022.12.14.520445
[7] FENGXIANG WANG . PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ[J]. Cell Chemical Biology, 2022, 29 1: Pages 157-170.e6. DOI: 10.1016/j.chembiol.2021.11.001
[8] DAVID A. ARMENTA . Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein[J]. Cell Chemical Biology, 2022, 29 11: Pages 1588-1600.e7. DOI: 10.1016/j.chembiol.2022.10.006
[9] ALEXANDER BEATTY. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1.[J]. ACS Combinatorial Science, 2021: 2244. DOI: 10.1038/s41467-021-22471-y
[10] WANLU DU. Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma.[J]. ACS Applied Polymer Materials, 2021: 109848. DOI: 10.1016/j.celrep.2021.109848
[11] PANDIAN NAGAKANNAN . Cathepsin B is an executioner of ferroptosis[J]. Biochimica et biophysica acta. Molecular cell research, 2021, 1868 3: Article 118928. DOI: 10.1016/j.bbamcr.2020.118928
[12] DANIEL M. KREMER. GOT1 Inhibition Primes Pancreatic Cancer for Ferroptosis through the Autophagic Release of Labile Iron[J]. bioRxiv?: the preprint server for biology, 2020, 8 1. DOI: 10.1101/2020.02.28.970228
[13] KIRILL BERSUKER. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis[J]. Nature, 2019, 575 7784: 688-692. DOI: 10.1038/s41586-019-1705-2
[14] JENNIFER YINUO CAO. A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity.[J]. Cell reports, 2019: 1544-1556.e8. DOI: 10.1016/j.celrep.2019.01.043
[15] ANAGHA SEN. MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1.[J]. PLoS ONE, 2013: e78684. DOI: 10.1371/journal.pone.0078684

DEFEROXAMINE MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DEFEROXAMINE MESYLATE manufacturers

Henan Fengda Chemical Co., Ltd

Product: DEFEROXAMINE MESYLATE 138-14-7
Price: US $8.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-24

Honest Joy Holdings Limited

Product: DeferoxaMine Mesylate 138-14-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.4%
Supply Ability: 100 tons
Release date: 2022-02-18

Career Henan Chemical Co

Product: DEFEROXAMINE MESYLATE 138-14-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

138-14-7, DEFEROXAMINE MESYLATERelated Search:

Hydroxyurea Deferoxamine AMMONIUM FERRIC CHLORIDE Ammonium ferric sulfate dodecahydrate Ferric ammonium EDTA Ferrous ammonium sulfate hexahydrate AMMONIUM IRON (III) HEXACYANOFERRATE (II) Ferric ammonium citrate,brown Ammonium iron(III) sulfate Ferric ammonium oxalate MAFA Ammonium ferric citrate DEFEROXAMINE MESYLATE Ferric ammonium oxalate trihydrate NOCARDAMINE ferrimycin A1 MAFA aqueous solution (5%) Deferoxamine Mesylate Salt

deferoxaminebmesylate

deferoxaminemesilate

deferoxaminemethanesulfonate

desferal

desferalmesylate

desferalmethanesulfonate

desferrioxaminebmesylate

Deferoxamine Mesylate (300 mg)

N-[5-[3-[(5-aMinopentyl)hydroxycarbaMoyl]propionaMido]pentyl]-3-[[5-(N-hydroxyacetaMido)

N1-(5-aMinopentyl)-N1-hydroxy-N4-[5-[[4-[[5-(acetylhydroxyaMino)pentyl]aMino]-1,4-dioxobutyl]hydroxyaMino]pentyl]butanediaMide Methanesulfonate

desferrioxaminebmethanesulfonate

monomethanesulfonate(sa

propionohydroxamicacid,n-(5-(3-((5-aminopentyl)hydroxycarbamoyl)propionamido)

Butanediamide, N-5-4-5-(acetylhydroxyamino)pentylamino-1,4-dioxobutylhydroxyaminopentyl-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate (salt)

STARCHDEFEROXAMINECONJUGATE

Desferrioxamine mesylate salt

Prestwick_988

Deferoxamine mesylate salt,DFOM, Deferoxamine methanesulfonate salt, Desferrioxamine mesylate salt

Deferoxamine Mesylate (500 mg)

DFOM

DESFERRIOXAMINE MESYLATE

DEFEROXAMINE MESYLATE

DEFEROXAMINE MESYLATE SALT

DEFEROXAMINE METHANESULFONATE SALT

N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxybutanediamide methanesulfonate

Desferioxamine mesylate

Deferoxamine Mesilate RS

desferrioxamine mesilate

Deferoxamine mesilate CRS

Deferoxamine for system suitability

DEFEROXAMINE MESYLATE USP/EP/BP

Deferoxamine Mesylate (1166003)

esferrioxamineBmesylate

N1-(5-(4-((5-Aminopentyl)amino)-4-oxobutanamido)pentyl)-N1-hydroxy-N4-(5-(N-hydroxyacetamido)pentyl)succinamide methanesulfonate

HIFs,neovascularization,TAMSCs,diabetes mellitus,Akt,PKB,Protein kinase B,Apoptosis,Autophagy,SH-SY5Y,Hypoxia-inducible factors,Deferoxamine,Deferoxamine Mesylate,Inhibitor,MEFs,cancer,Alzheimer’s disease,HIF-PH,Reactive Oxygen Species,BMMSCs,inhibit,HIF/HIF Prolyl-Hydroxylase,COVID-19

Deferoxamine mesylate USP/Ph. Eur

Deferiprone Impurity 3

Deferoxamine mesylate, Iron chelator

Deferoxamine Mesylate, 10 mM in DMSO

N1-(5-Aminopentyl)-N1-hydroxy-N4-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)pentyl)amino)-4-oxobutanamido)pentyl)succinamide methanesulfonate

Deferoxamine mesylate salt【D0160000】

138-14-7

C26H52N6O11S

C25H48N6O8CH4O3S

C25H48N6O8CH4SO3

Inhibitors

DESFERAL

Pharmaceuticals

Aliphatics

Amines

Chelating Agents & Ligands

Intermediates & Fine Chemicals