DEFEROXAMINE MESYLATE
- Product Name
- DEFEROXAMINE MESYLATE
- CAS No.
- 138-14-7
- Chemical Name
- DEFEROXAMINE MESYLATE
- Synonyms
- DFOM;desferal;DESFERRIOXAMINE MESYLATE;deferoxaminebmesylate;Desferioxamine mesylate;desferrioxamine mesilate;DEFEROXAMINE MESYLATE SALT;Prestwick_988;desferalmesylate;deferoxaminemesilate
- CBNumber
- CB4372020
- Molecular Formula
- C26H52N6O11S
- Formula Weight
- 656.79
- MOL File
- 138-14-7.mol
DEFEROXAMINE MESYLATE Property
- Melting point:
- 148-149°
- storage temp.
- 2-8°C
- solubility
- H2O: 50 mg/mL
- form
- powder
- color
- white to off-white
- Water Solubility
- Soluble to 100 mM in water
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 2
- RTECS
- UG5310000
- HS Code
- 29280000
- Toxicity
- man,TDLo,parenteral,16gm/kg/34W-I (16000mg/kg),CARDIAC: PERICARDITISGASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINEBLOOD: OTHER CHANGES,American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D9533
- Product name
- Deferoxamine mesylate salt
- Purity
- powder, ≥92.5% (TLC)
- Packaging
- 1g
- Price
- $142
- Updated
- 2024/03/01
- Product number
- 252750
- Product name
- Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem
- Purity
- Parenteralironchelatingagent.Commonlyusedintherapyasachelatorofferri
- Packaging
- 1g
- Price
- $210
- Updated
- 2024/03/01
- Product number
- 1166003
- Product name
- Deferoxamine mesylate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 300mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- Y0001934
- Product name
- Deferoxamine for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0001934
- Price
- $218
- Updated
- 2023/06/20
- Product number
- 14595
- Product name
- Deferoxamine (mesylate)
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $73
- Updated
- 2024/03/01
DEFEROXAMINE MESYLATE Chemical Properties,Usage,Production
Description
Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-
Chemical Properties
DEFEROXAMINE MESYLATE is white or almost white powder.
Uses
chelating agent (Fe & Al)
Uses
DEFEROXAMINE MESYLATE is an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients
brand name
Desferal (Novartis).
Biochem/physiol Actions
An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.
Clinical Use
Chelating agent:
Acute iron poisoning
Chronic iron or aluminium overload
Veterinary Drugs and Treatments
Deferoxamine is used for the treatment of either acute or chronic iron toxicity. It is being evaluated as an iron chelator for adjunctive treatment of acute cardiac ischemia and as a chelator for aluminum toxicity. Its efficacy in treating reperfusion injuries has been disappointing.
Drug interactions
Potentially hazardous interactions with other drugs
Avoid prochlorperazine, levomepromazine and
methotrimeprazine (prolonged unconsciousness).
Do not administer with blood.
Metabolism
When given parenterally desferrioxamine forms chelates with iron and aluminium ions to form ferrioxamine and aluminoxamine, respectively. The chelates are excreted in the urine and faeces via the bile. Desferrioxamine is metabolised, mainly in the plasma. Four metabolites of desferrioxamine were isolated from urine of patients with iron overload. The following biotransformation reactions were found to occur with desferrioxamine: transamination and oxidation yielding an acid metabolite, beta-oxidation also yielding an acid metabolite, decarboxylation and N-hydroxylation yielding neutral metabolites.
storage
Store at -20°C
DEFEROXAMINE MESYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
DEFEROXAMINE MESYLATE Suppliers
View Lastest Price from DEFEROXAMINE MESYLATE manufacturers
- Product
- DEFEROXAMINE MESYLATE 138-14-7
- Price
- US $8.00-2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-24
- Product
- DeferoxaMine Mesylate 138-14-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.4%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- DEFEROXAMINE MESYLATE 138-14-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 0.999
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-13