GW5074
- Product Name
- GW5074
- CAS No.
- 220904-83-6
- Chemical Name
- GW5074
- Synonyms
- W5074;GW5074;CS-399;GW5074, >=98%;GW-5074;GW 5074;GW5074 USP/EP/BP;GW 5074;GW-5074;GW5074;RAF1 KINASE INHIBITOR I;Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem;3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
- CBNumber
- CB0130215
- Molecular Formula
- C15H8Br2INO2
- Formula Weight
- 520.94
- MOL File
- 220904-83-6.mol
GW5074 Property
- Boiling point:
- 561.4±50.0 °C(Predicted)
- Density
- 2.248±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble
- pka
- 5.86±0.25(Predicted)
- form
- solid
- color
- yellow to orange-brown
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- LMXYVLFTZRPNRV-XCVCLJGOSA-N
- CAS DataBase Reference
- 220904-83-6
Safety
- WGK Germany
- 3
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- G6416
- Product name
- GW5074
- Purity
- powder
- Packaging
- 5mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 553008
- Product name
- Raf1 Kinase Inhibitor I
- Packaging
- 1mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- 10010368
- Product name
- GW 5074
- Purity
- ≥98% (mixture of cis and trans)
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 10010368
- Product name
- GW 5074
- Purity
- ≥98% (mixture of cis and trans)
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- G6416
- Product name
- GW5074
- Purity
- powder
- Packaging
- 25mg
- Price
- $649
- Updated
- 2024/03/01
GW5074 Chemical Properties,Usage,Production
Description
GW-5074 (220904-83-6) is a potent inhibitor of cRAF1 kinase (IC50 = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW-5074 displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling. Cell permeable.
Uses
GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.
Biological Activity
Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC 50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.
Biochem/physiol Actions
GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.
storage
Desiccate at -20°C
References
1) Chang et al. (2005), Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK pathways; Cell Signal., 217 299 2) Huang et al. (2006), Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway; J. Pharmacol. Sci., 102 305 3) Lackey et al. (2000), The discovery of potent cRaf1 kinase inhibitors; Bioorg. Med. Chem. Lett., 10 223 4) Chen et al. (2004), Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells; J. Immunol., 173 5219
GW5074 Preparation Products And Raw materials
Raw materials
Preparation Products
GW5074 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
- Tel
- --
- Fax
- --
- solutions@vwr.com
- Country
- United Kingdom
- ProdList
- 6548
- Advantage
- 82
View Lastest Price from GW5074 manufacturers
- Product
- (3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one 220904-83-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23
- Product
- (3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one 220904-83-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-20