GW5074

Product Name: GW5074
CAS No.: 220904-83-6
Chemical Name: GW5074
Synonyms: W5074;GW5074;CS-399;GW5074, >=98%;GW-5074;GW 5074;GW5074 USP/EP/BP;GW 5074;GW-5074;GW5074;RAF1 KINASE INHIBITOR I;Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem;3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
CBNumber: CB0130215
Molecular Formula: C15H8Br2INO2
Formula Weight: 520.94
MOL File: 220904-83-6.mol

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GW5074 Property

Boiling point:: 561.4±50.0 °C(Predicted)
Density: 2.248±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: soluble
pka: 5.86±0.25(Predicted)
form: solid
color: yellow to orange-brown
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey: LMXYVLFTZRPNRV-XCVCLJGOSA-N
CAS DataBase Reference: 220904-83-6

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Safety

WGK Germany: 3
HS Code: 2933790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G6416
Product name: GW5074
Purity: powder
Packaging: 5mg
Price: $166
Updated: 2024/03/01

Sigma-Aldrich

Product number: 553008
Product name: Raf1 Kinase Inhibitor I
Packaging: 1mg
Price: $187
Updated: 2024/03/01

Cayman Chemical

Product number: 10010368
Product name: GW 5074
Purity: ≥98% (mixture of cis and trans)
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 10010368
Product name: GW 5074
Purity: ≥98% (mixture of cis and trans)
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: G6416
Product name: GW5074
Purity: powder
Packaging: 25mg
Price: $649
Updated: 2024/03/01

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GW5074 Chemical Properties,Usage,Production

Description

GW-5074 (220904-83-6) is a potent inhibitor of cRAF1 kinase (IC50 = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW-5074 displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling. Cell permeable.

Uses

GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.

Biological Activity

Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC 50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.

Biochem/physiol Actions

GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.

storage

Desiccate at -20°C

References

1) Chang et al. (2005), Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK pathways; Cell Signal., 217 299 2) Huang et al. (2006), Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway; J. Pharmacol. Sci., 102 305 3) Lackey et al. (2000), The discovery of potent cRaf1 kinase inhibitors; Bioorg. Med. Chem. Lett., 10 223 4) Chen et al. (2004), Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells; J. Immunol., 173 5219

GW5074 Preparation Products And Raw materials

Raw materials

Preparation Products

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GW5074 Suppliers

China 121 Germany 1 India 1 Japan 1 Switzerland 2 United Kingdom 2 United States 23 Global 151

VDM Biochemicals

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View Lastest Price from GW5074 manufacturers

Career Henan Chemical Co

Product: (3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one 220904-83-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-23

Career Henan Chemical Co

Product: (3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one 220904-83-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-20

220904-83-6, GW5074Related Search:

GW284543 GW788388 GW9662 GW441756 Everolimus Sorafenib Alisertib (MLN8237) Dasatinib SCH772984 Tofacitinib GW 284543 hydrochloride - UNC 10225170 hydrochloride 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine GW9508 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- GW5074 6-IODO-2,3-DIHYDRO-1H-INDOLE 2H-INDOL-2-ONE, 1,3-DIHYDRO-5-IODO- 2-ETHYL-4-IODO-PHENYLAMINE

RAF1 KINASE INHIBITOR I

(3Z)-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLIDENE]-5-IODO-1H-INDOL-2-ONE

5-IODO-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLENE]-2-INDOLINONE

3-(3,5-DIBROMO-4-HYDROXY-BENZYLIDENE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE

3-(3,5-DIBROMO-4-HYDROXYBENZYLIDINE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE

GW5074

2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-

3-(3,5-dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one

GW5074, >=98%

(Z)-3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one

GW-5074;GW 5074

Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem

GW 5074;GW-5074;GW5074

CS-399

W5074

GW5074 USP/EP/BP

3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-2,3-dihydro-1H-indol-2-one

3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one

(3E)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one

220904-83-6

20904-83-6

C15H8Br2INO2

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Kinase/Phosphatase Biology

Raf

Serine/Threonine Kinase Inhibitors

MAPK

Inhibitors