psicofuranine
- Product Name
- psicofuranine
- CAS No.
- 1874-54-0
- Chemical Name
- psicofuranine
- Synonyms
- U-9586;NSC 53104;psicofuranin;psicofuranine;Angustmycin C;Psicofuranosyladenine;1'-(Hydroxymethyl)adenosine;Psicofuranine [AngustMycin C];9-beta-D-Psicofuranosyladenine;Adenosine, 1'-C-(hydroxymethyl)-
- CBNumber
- CB01334610
- Molecular Formula
- C11H15N5O5
- Formula Weight
- 297.27
- MOL File
- 1874-54-0.mol
psicofuranine Property
- Melting point:
- 212-214℃ (decomposition)
- alpha
- D25 -68° (dimethylformamide)
- Boiling point:
- 720.1±70.0 °C(Predicted)
- Density
- 2.02±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- solid
- pka
- 12.87±0.70(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 19574
- Product name
- Psicofuranine
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 19574
- Product name
- Psicofuranine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $414
- Updated
- 2024/03/01
- Product number
- 207362
- Product name
- Psicofuranine
- Packaging
- 1mg
- Price
- $316
- Updated
- 2021/12/16
- Product number
- P839628
- Product name
- Psicofuranine
- Packaging
- 1mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- API0025389
- Product name
- PSICOFURANINE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $224.7
- Updated
- 2021/12/16
psicofuranine Chemical Properties,Usage,Production
Uses
Psicofuranine is an antibiotic and antitumor compound that acts as an inhibitor of xanthosine monophosphate (XMP) aminase (IC50 = 67 μM), causing guanine deficiency in enteric bacteria.[Cayman Chemical]
Uses
Psicofuranine is a nucleoside antibiotic shown to inhibit xanthosine monophosphate aminase.
Definition
ChEBI: Psicofuranin is a purine nucleoside and a psicose derivative.
Biological Activity
psicofuranine is an antibiotic that acts as an inhibitor of xanthosine 5’-phosphate (xmp) aminase with ic50 value of 67 μm [1][2][3].xanthosine 5’-phosphate (xmp) aminase is an enzyme essential for guanine nucleotide synthesis and possess catalytic activity with either glutamine or ammonia as a substrate [2][3].psicofuranine (9-n-psicofuranosy-6-aminopurine) is an antibiotic that acts as an inhibitor of xanthosine 5’-phosphate (xmp) aminase with ic50 value of 67 μm. in unfractionated preparations of both strains b-24 and b-35-2, 6.7 x 10-5m psicofuranin inhibited 50% xmp aminase after 2 minutes. psicofuranine caused a guanine deficiency in enteric bacteria by inhibition of xmp aminase [2]. psicofuranine-inhibited aminase couldn’t catalyze the aminolysis of the preformed intermediate to amp and gmp, nor could it condense atp and xmp to form the intermediate [3]. psicofuranine had good antibacterial activity in vivo and antitumor activity [1].
Enzyme inhibitor
This adenosine analogue (FW = 297.27 g/mol; CAS 1874-54-0), also known as 6-amino-9-D-psicofuranosylpurine, 9b-D-(psicofuranosyl)- adenine, and angustmycin C, is a nucleoside antibiotic isolated from Streptomyces hygroscopicus that also exhibits antitumor activity. Psicofuranine is soluble in water (8 mg/mL at 25°C) and has a lmax value of 261 nm in 10 mM base or 259 nm in 10 mM acid. Psicofuranine is an irreversible inhibitor of GMP synthetase that acts by preventing the release (or further reaction) of adenyl-XMP with water or ammonia; however, it does not suppress exchange reactions. Target(s): deoxycytidine kinase, weakly inhibited, Ki = 12 mM; GMP synthetase, or XMP aminase (2- 11); and NAD+ synthetase.
storage
+4°C
References
[1]. ladislav j. hanka. mechanism of action of psicofuranine. j bacteriol. 1960 jul; 80(1): 30–36.
[2]. udaka s, moyed hs. inhibition of parental and mutant xanthosine 5'-phosphate aminases by psicofuranine. j biol chem. 1963 aug;238:2797-803.
[3]. fukuyama tt. formation of an adenyl xanthosine monophosphate intermediate by xanthosine 5'-phosphate aminase and its inhibition by psicofuranine. j biol chem. 1966 oct 25;241(20):4745-9.
psicofuranine Preparation Products And Raw materials
Raw materials
Preparation Products
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