ChemicalBook > CAS DataBase List > psicofuranine

psicofuranine

Product Name
psicofuranine
CAS No.
1874-54-0
Chemical Name
psicofuranine
Synonyms
U-9586;NSC 53104;psicofuranin;psicofuranine;Angustmycin C;Psicofuranosyladenine;1'-(Hydroxymethyl)adenosine;Psicofuranine [AngustMycin C];9-beta-D-Psicofuranosyladenine;9-beta-D-psicofuranyl adenosine
CBNumber
CB01334610
Molecular Formula
C11H15N5O5
Formula Weight
297.27
MOL File
1874-54-0.mol
More
Less

psicofuranine Property

Melting point:
212-214℃ (decomposition)
alpha 
D25 -68° (dimethylformamide)
Boiling point:
720.1±70.0 °C(Predicted)
Density 
2.02±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
solid
pka
12.87±0.70(Predicted)
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
19574
Product name
Psicofuranine
Purity
≥98%
Packaging
1mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
19574
Product name
Psicofuranine
Purity
≥98%
Packaging
5mg
Price
$414
Updated
2024/03/01
TRC
Product number
P839628
Product name
Psicofuranine
Packaging
1mg
Price
$115
Updated
2021/12/16
Usbiological
Product number
207362
Product name
Psicofuranine
Packaging
1mg
Price
$316
Updated
2021/12/16
Adipogen Life Sciences
Product number
BVT-0284-M001
Product name
Psicofuranine
Purity
≥98%(HPLC,TLC)
Packaging
1mg
Price
$80
Updated
2021/12/16
More
Less

psicofuranine Chemical Properties,Usage,Production

Uses

Psicofuranine is an antibiotic and antitumor compound that acts as an inhibitor of xanthosine monophosphate (XMP) aminase (IC50 = 67 μM), causing guanine deficiency in enteric bacteria.[Cayman Chemical]

Uses

Psicofuranine is a nucleoside antibiotic shown to inhibit xanthosine monophosphate aminase.

Definition

ChEBI: Psicofuranin is a purine nucleoside and a psicose derivative.

Biological Activity

psicofuranine is an antibiotic that acts as an inhibitor of xanthosine 5’-phosphate (xmp) aminase with ic50 value of 67 μm [1][2][3].xanthosine 5’-phosphate (xmp) aminase is an enzyme essential for guanine nucleotide synthesis and possess catalytic activity with either glutamine or ammonia as a substrate [2][3].psicofuranine (9-n-psicofuranosy-6-aminopurine) is an antibiotic that acts as an inhibitor of xanthosine 5’-phosphate (xmp) aminase with ic50 value of 67 μm. in unfractionated preparations of both strains b-24 and b-35-2, 6.7 x 10-5m psicofuranin inhibited 50% xmp aminase after 2 minutes. psicofuranine caused a guanine deficiency in enteric bacteria by inhibition of xmp aminase [2]. psicofuranine-inhibited aminase couldn’t catalyze the aminolysis of the preformed intermediate to amp and gmp, nor could it condense atp and xmp to form the intermediate [3]. psicofuranine had good antibacterial activity in vivo and antitumor activity [1].

Enzyme inhibitor

This adenosine analogue (FW = 297.27 g/mol; CAS 1874-54-0), also known as 6-amino-9-D-psicofuranosylpurine, 9b-D-(psicofuranosyl)- adenine, and angustmycin C, is a nucleoside antibiotic isolated from Streptomyces hygroscopicus that also exhibits antitumor activity. Psicofuranine is soluble in water (8 mg/mL at 25°C) and has a lmax value of 261 nm in 10 mM base or 259 nm in 10 mM acid. Psicofuranine is an irreversible inhibitor of GMP synthetase that acts by preventing the release (or further reaction) of adenyl-XMP with water or ammonia; however, it does not suppress exchange reactions. Target(s): deoxycytidine kinase, weakly inhibited, Ki = 12 mM; GMP synthetase, or XMP aminase (2- 11); and NAD+ synthetase.

storage

+4°C

References

[1]. ladislav j. hanka. mechanism of action of psicofuranine. j bacteriol. 1960 jul; 80(1): 30–36.
[2]. udaka s, moyed hs. inhibition of parental and mutant xanthosine 5'-phosphate aminases by psicofuranine. j biol chem. 1963 aug;238:2797-803.
[3]. fukuyama tt. formation of an adenyl xanthosine monophosphate intermediate by xanthosine 5'-phosphate aminase and its inhibition by psicofuranine. j biol chem. 1966 oct 25;241(20):4745-9.

psicofuranine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

psicofuranine Suppliers

Nanjing Baifuli Technology Co., Ltd.
Tel
25-25-58740604 15951658055
Fax
+86-25-58356858
Email
sales@unisyn.cn
Country
China
ProdList
561
Advantage
58
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
NewCan Biotech Limited
Tel
+86-0571-86912261 +8613735419629
Email
sales@newcanbio.com
Country
China
ProdList
9981
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30238
Advantage
58
Nanjing Baifuli Technology Co., Ltd.
Tel
+86-15335185688
Email
sales@unisyn.cn
Country
CHINA
ProdList
332
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-89903882 13626641628
Email
jiangnan@huidabiotech.com
Country
China
ProdList
3656
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44806
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-0571-89903882 15990081639
Email
sunshixuan@huidabiotech.com
Country
China
ProdList
3705
Advantage
58
Panaishen (Henan) Pharmaceutical Science and Technology Co. , Ltd.
Tel
0371-65325800 13700860222
Email
haifeng.zhang@pannacean.com
Country
China
ProdList
637
Advantage
58
G-CLONE
Tel
400-910-1997 17560619001
Email
3243204476@qq.com
Country
China
ProdList
9959
Advantage
58
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD
Tel
0371-55159968 18137130222
Email
haifeng.zhang@pannacean.com
Country
China
ProdList
645
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Beijing Taize Jiaye Technology Development Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6050
Advantage
58
Shanghai Silk Dragon Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
3988
Advantage
58
Beijing Sizhengbai Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
marketing@4abio.com
Country
CHINA
ProdList
6401
Advantage
58
Shanghai Haoran Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
470003480@QQ.COM
Country
CHINA
ProdList
6955
Advantage
58
Beijing Luyuan Bird Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
15810802415@139.com
Country
CHINA
ProdList
6750
Advantage
58
Beijing Dongge Boye Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1861586486@qq.com
Country
CHINA
ProdList
6648
Advantage
58
Boao Pike
Tel
--
Fax
--
Email
lyn@biopike.com.cn
Country
CHINA
ProdList
6629
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
market@xlswkj.com
Country
CHINA
ProdList
6793
Advantage
58
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6973
Advantage
58
Beijing Bai Ao Si Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
yangmei@bioneeds.net
Country
CHINA
ProdList
6999
Advantage
58
Beijing Lebo Biotechnology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6057
Advantage
58
Xiamen Research Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1562893815@qq.com
Country
CHINA
ProdList
6936
Advantage
58
Morning Student Science and Technology (Guangzhou) Co., Ltd.
Tel
--
Fax
--
Email
chenxue_gz@163.com
Country
CHINA
ProdList
6600
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6906
Advantage
58
Beijing Baiao Innovation Technology Co., Ltd.
Tel
--
Fax
--
Email
3007606172@qq.com
Country
CHINA
ProdList
6002
Advantage
58
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1985563437@qq.com
Country
CHINA
ProdList
6158
Advantage
58
Shanghai Minmin Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1914109725@qq.com
Country
CHINA
ProdList
6518
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Beijing Fubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
info@f-biology.com
Country
CHINA
ProdList
6025
Advantage
58
Shenzhen Xinbosheng Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
service@neobioscience.com
Country
CHINA
ProdList
6151
Advantage
58

1874-54-0, psicofuranineRelated Search:


  • psicofuranine
  • 9-(β-D-Psicofuranosyl)-9H-purin-6-amine
  • 9-β-D-Psicofuranosyl-9H-purin-6-amine
  • Angustmycin C
  • Psicofuranosyladenine
  • U-9586
  • Psicofuranine [AngustMycin C]
  • 1'-(Hydroxymethyl)adenosine
  • 9-beta-D-Psicofuranosyl-6-aminopurine
  • 9-beta-D-Psicofuranosyladenine
  • NSC 53104
  • psicofuranin
  • Adenosine, 1'-C-(hydroxymethyl)-
  • 9-beta-D-psicofuranyl adenosine
  • Psicofuranine, Adenosine analog
  • 1874-54-0