4-(Methylsulfonyl)phenol
- Product Name
- 4-(Methylsulfonyl)phenol
- CAS No.
- 14763-60-1
- Chemical Name
- 4-(Methylsulfonyl)phenol
- Synonyms
- 4-(METHYLSULFONYL)PHENOL;4-METHYLSULPHONYLPHENOL;4-Mesylphenol;4-Methylsulfonylphen;p-Methylsulphonylphenol;4-(methylsulfonyl)-pheno;4-METHANESULFONYL-PHENOL;p-(Methylsulfonyl)phenol;p-(methylsulfonyl)-pheno;4-METHANESULPHONYLPHENOL
- CBNumber
- CB0135245
- Molecular Formula
- C7H8O3S
- Formula Weight
- 172.2
- MOL File
- 14763-60-1.mol
4-(Methylsulfonyl)phenol Property
- Melting point:
- 90-95 °C
- Boiling point:
- 272.52°C (rough estimate)
- Density
- 1.3692 (rough estimate)
- refractive index
- 1.5151 (estimate)
- RTECS
- SM1530000
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO, Methanol
- form
- Powder
- pka
- pK1:7.83 (25°C)
- color
- Tan to pink-brown
- Water Solubility
- slight
- BRN
- 1866322
- LogP
- 0.886 (est)
- CAS DataBase Reference
- 14763-60-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-(Methylsulfonyl)phenol(14763-60-1)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H1367
- Product name
- 4-Hydroxyphenyl Methyl Sulfone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- H1367
- Product name
- 4-Hydroxyphenyl Methyl Sulfone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $123
- Updated
- 2025/07/31
- Product number
- M329450
- Product name
- 4-(Methylsulfonyl)phenol
- Packaging
- 10g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- M329450
- Product name
- 4-(Methylsulfonyl)phenol
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- JK145047
- Product name
- 4-Methylsulphonylphenol
- Purity
- 97%
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
4-(Methylsulfonyl)phenol Chemical Properties,Usage,Production
Chemical Properties
Tan to pink-brown powder
Uses
4-(Methylsulfonyl)phenol is a reagent in the synthesis of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Also a reagent in the synthesis of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.
Reactions
The reaction of 4-(methylsulfonyl)phenol (17.2 g, 100.0 mmol) with p-Toluenesulfonic anhydride as outlined in the general procedure provided 4-(methylsulfonyl)phenyl 4-methylbenzenesulfonate (26.1 g, 81%).
Synthesis
1073-72-9
14763-60-1
Step 2. Synthesis of 4-(methylsulfonyl)phenol Oxone (0.99 g, 6.5 mmol) was added batchwise to a solution of 4-(methylthio)phenol (0.50 g, 3.2 mmol) in ethanol (10.0 mL). Subsequently, water (10.0 mL) was added at room temperature. The reaction mixture was stirred for 18 h, after which it was partitioned between ethyl acetate and water. The combined organic layers were washed with brine, dried over magnesium sulfate, and concentrated under vacuum to afford 4-(methylsulfonyl)phenol as a semi-solid (0.60 g, 96% yield). LCMS calculated value C7H9O3S ([M + H]+): m/z = 173.0; measured value: 173.0.
References
[1] Patent: WO2015/164480, 2015, A1. Location in patent: Page/Page column 106; 107
[2] Journal of Organic Chemistry, 2003, vol. 68, # 13, p. 5388 - 5391
[3] Green Chemistry, 2014, vol. 16, # 4, p. 2190 - 2196
[4] Journal of the Indian Chemical Society, 1982, vol. 59, # 1, p. 52 - 54
[5] Patent: EP1598349, 2005, A1. Location in patent: Page/Page column 127
4-(Methylsulfonyl)phenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Methylsulfonyl)phenol manufacturers
- Product
- 4-(Methylsulfonyl)phenol 14763-60-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tons
- Release date
- 2025-08-19
- Product
- 4-(Methylsulfonyl)phenol 14763-60-1
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-24
- Product
- 4-Methylsulfonylphenol 14763-60-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-19