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4-(Methylsulfonyl)phenol

Product Name
4-(Methylsulfonyl)phenol
CAS No.
14763-60-1
Chemical Name
4-(Methylsulfonyl)phenol
Synonyms
4-(METHYLSULFONYL)PHENOL;4-METHYLSULPHONYLPHENOL;4-Mesylphenol;4-Methylsulfonylphen;p-Methylsulphonylphenol;4-(methylsulfonyl)-pheno;4-METHANESULFONYL-PHENOL;p-(Methylsulfonyl)phenol;p-(methylsulfonyl)-pheno;4-METHANESULPHONYLPHENOL
CBNumber
CB0135245
Molecular Formula
C7H8O3S
Formula Weight
172.2
MOL File
14763-60-1.mol
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4-(Methylsulfonyl)phenol Property

Melting point:
90-95 °C
Boiling point:
272.52°C (rough estimate)
Density 
1.3692 (rough estimate)
refractive index 
1.5151 (estimate)
RTECS 
SM1530000
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO, Methanol
form 
Powder
pka
pK1:7.83 (25°C)
color 
Tan to pink-brown
Water Solubility 
slight
BRN 
1866322
LogP
0.886 (est)
CAS DataBase Reference
14763-60-1(CAS DataBase Reference)
NIST Chemistry Reference
4-(Methylsulfonyl)phenol(14763-60-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
24/25-26
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H1367
Product name
4-Hydroxyphenyl Methyl Sulfone
Purity
>98.0%(GC)
Packaging
5g
Price
$37
Updated
2025/07/31
TCI Chemical
Product number
H1367
Product name
4-Hydroxyphenyl Methyl Sulfone
Purity
>98.0%(GC)
Packaging
25g
Price
$123
Updated
2025/07/31
TRC
Product number
M329450
Product name
4-(Methylsulfonyl)phenol
Packaging
10g
Price
$105
Updated
2021/12/16
TRC
Product number
M329450
Product name
4-(Methylsulfonyl)phenol
Packaging
1g
Price
$55
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK145047
Product name
4-Methylsulphonylphenol
Purity
97%
Packaging
5g
Price
$65
Updated
2021/12/16
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4-(Methylsulfonyl)phenol Chemical Properties,Usage,Production

Chemical Properties

Tan to pink-brown powder

Uses

4-(Methylsulfonyl)phenol is a reagent in the synthesis of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Also a reagent in the synthesis of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.

Reactions

The reaction of 4-(methylsulfonyl)phenol (17.2 g, 100.0 mmol) with p-Toluenesulfonic anhydride as outlined in the general procedure provided 4-(methylsulfonyl)phenyl 4-methylbenzenesulfonate (26.1 g, 81%).

Synthesis

1073-72-9

14763-60-1

Step 2. Synthesis of 4-(methylsulfonyl)phenol Oxone (0.99 g, 6.5 mmol) was added batchwise to a solution of 4-(methylthio)phenol (0.50 g, 3.2 mmol) in ethanol (10.0 mL). Subsequently, water (10.0 mL) was added at room temperature. The reaction mixture was stirred for 18 h, after which it was partitioned between ethyl acetate and water. The combined organic layers were washed with brine, dried over magnesium sulfate, and concentrated under vacuum to afford 4-(methylsulfonyl)phenol as a semi-solid (0.60 g, 96% yield). LCMS calculated value C7H9O3S ([M + H]+): m/z = 173.0; measured value: 173.0.

References

[1] Patent: WO2015/164480, 2015, A1. Location in patent: Page/Page column 106; 107
[2] Journal of Organic Chemistry, 2003, vol. 68, # 13, p. 5388 - 5391
[3] Green Chemistry, 2014, vol. 16, # 4, p. 2190 - 2196
[4] Journal of the Indian Chemical Society, 1982, vol. 59, # 1, p. 52 - 54
[5] Patent: EP1598349, 2005, A1. Location in patent: Page/Page column 127

4-(Methylsulfonyl)phenol Preparation Products And Raw materials

Raw materials

Hydrogen peroxide Acetyl chloride Chloroform Carbon tetrachloride Ethyl acetate Hydrochloric acid Acetic acid Sodium periodate Sodium hydroxide 4-(Methylthio)phenol Magnesium sulfate

Preparation Products

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4-(Methylsulfonyl)phenol Suppliers

Americas 1 Belgium 2 China 109 Europe 3 France 1 Germany 3 India 4 Japan 3 Switzerland 1 United Kingdom 17 United States 28 USA 1 Global 173
Dr. Ehrenstorfer GmbH
Tel
--
Fax
--
Email
info@analytical-standards.com
Country
Germany
ProdList
5545
Advantage
66
CHEMOS GmbH & Co. KG
Tel
--
Fax
--
Email
chemos@chemos.de
Country
Germany
ProdList
6727
Advantage
58
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from 4-(Methylsulfonyl)phenol manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.
Product
4-(Methylsulfonyl)phenol 14763-60-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
20tons
Release date
2025-08-19
Henan Fengda Chemical Co., Ltd
Product
4-(Methylsulfonyl)phenol 14763-60-1
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-24
Hebei Zhanyao Biotechnology Co. Ltd
Product
4-Methylsulfonylphenol 14763-60-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-10-19

14763-60-1, 4-(Methylsulfonyl)phenolRelated Search:

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