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demethylzeylasteral

Product Name
demethylzeylasteral
CAS No.
107316-88-1
Chemical Name
demethylzeylasteral
Synonyms
demethylzeylasteral;Demethylzeylasteral-RM;Demethylzeylasteral(T-96);Demethylzeylasteral, 10 mM in DMSO;A-Friedo-24-noroleana-1,3,5(10),7-tetraen-29-oicacid;24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-6,23-dioxo-, (9β,13α,14β,20α)-;(9beta,13alpha,14beta,20alpha)-2,3-Dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oic acid;(2R,4AS,6aS,12bR,14aS,14bR)-9-formyl-10,11-dihydroxy-2,4a,6a,12b,14a-pentamethyl-8-oxo-1,2,3,4,4a,5,6,6a,8,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
CBNumber
CB01371631
Molecular Formula
C29H36O6
Formula Weight
480.59
MOL File
107316-88-1.mol
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demethylzeylasteral Property

Melting point:
>221°C (dec.)
Boiling point:
663.6±55.0 °C(Predicted)
Density 
1.31
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.78±0.70(Predicted)
color 
Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28595
Product name
Demethylzeylasteral
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
28595
Product name
Demethylzeylasteral
Packaging
10mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
28595
Product name
Demethylzeylasteral
Packaging
1mg
Price
$32
Updated
2024/03/01
TRC
Product number
D231408
Product name
Demethylzeylasteral
Packaging
1mg
Price
$45
Updated
2021/12/16
Usbiological
Product number
300174
Product name
Demethylzeylasteral
Packaging
20mg
Price
$320
Updated
2021/12/16
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demethylzeylasteral Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Tripterygium wilfordii.

Uses

Demethylzeylasteral is a natural product as new inhibitor to block the Bcl-XL-Bid interaction. Also, it is an immunosuppressive monomer isolated from the root xylem of Tripterygium wilfordii. It exhibits inhibition towards the glucuronidation elimination reaction of SN-38.

Definition

ChEBI: A carbopolycyclic compound with formula C29H36O6, originally isolated from Tripterygium wilfordii.

in vivo

Demethylzeylasteral (30 mg/kg, 6 times every 2 days, i.p.) inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis[1]. Demethylzeylasteral (4 mg/kg, 5 weeks, i.p.) inhibits the invasion of triple negative breast cancer by blocking classical and non classical TGF - β signaling pathways[2]. Demethylzeylasteral (30-120 mg/kg, 8 weeks, i.p.) improves inflammation in a unilateral ureteral obstruction rat model by inhibiting the activation of the NF - κ B pathway[4]. Demethylzeylasteral (10, 40 mg/kg, 30 days, i.g.) can alleviate atherosclerosis in AS rabbits[5]. Demethylzeylasteral (10, 20 mg/kg, 4 weeks, p.o.) improves CCl4 induced liver fibrosis in mice by inhibiting AGAP2 mediated FAK/AKT signaling[6].

Animal Model:Female nude mice modeled with glioma LN-229 cells[1].
Dosage:30 mg/kg, 6 times every 2 days
Administration:Intraperitoneal injection (i.p.)
Result:Reduced tumor volume
Animal Model:Female BALB/c mice modeled with 4T1 cells[2].
Dosage:4 mg/kg, 5 weeks
Administration:Intraperitoneal injection (i.p.)
Result:Reduced cancer lung metastasis
Animal Model:Rat model of unilateral ureteral obstruction[4].
Dosage:30-120 mg/kg, 8 weeks
Administration:Intraperitoneal injection (i.p.)
Result:Inhibited the increases in serum creatinine, blood urea nitrogen and Up/Ucr ratio
Animal Model:Atherosclerotic rabbit[5].
Dosage:10, 40 mg/kg, 30 days
Administration:Intragastrical (i.g.)
Result:Reduced blood lipids triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-C)
Animal Model:CCl4-induced liver fibrosis model[6].
Dosage:10, 20 mg/kg, 4 weeks
Administration:Oral gavage (p.o.)
Result:Inhibited the expression of TGF-β1

demethylzeylasteral Preparation Products And Raw materials

Raw materials

Preparation Products

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demethylzeylasteral Suppliers

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View Lastest Price from demethylzeylasteral manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
demethylzeylasteral 107316-88-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2025-06-27
Shanghai Standard Technology Co., Ltd.
Product
Demethylzeylasteral 107316-88-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-13
Career Henan Chemical Co
Product
demethylzeylasteral 107316-88-1
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10000kg
Release date
2018-08-10

107316-88-1, demethylzeylasteralRelated Search:

Celastrol Triptonide WILFORLIDE A tripterifordin TRIPTOPHENOLIDE WILFORDINE Triptolide wilfortrine WILFORINE

  • demethylzeylasteral
  • (9beta,13alpha,14beta,20alpha)-2,3-Dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oic acid
  • A-Friedo-24-noroleana-1,3,5(10),7-tetraen-29-oicacid
  • Demethylzeylasteral(T-96)
  • 24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-6,23-dioxo-, (9β,13α,14β,20α)-
  • (2R,4AS,6aS,12bR,14aS,14bR)-9-formyl-10,11-dihydroxy-2,4a,6a,12b,14a-pentamethyl-8-oxo-1,2,3,4,4a,5,6,6a,8,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
  • Demethylzeylasteral-RM
  • Demethylzeylasteral, 10 mM in DMSO
  • 107316-88-1
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract