Pharmacological effects Application
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Celastrol

Pharmacological effects Application
Product Name
Celastrol
CAS No.
34157-83-0
Chemical Name
Celastrol
Synonyms
Tripterine;Celastro;TRIPTERIN;NSC70931;Celatrol;CELASTROL;Celasterol;CELASTROL(SH);Celastrol >Celastrol ,98%
CBNumber
CB7146431
Molecular Formula
C29H38O4
Formula Weight
450.61
MOL File
34157-83-0.mol
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Celastrol Property

Melting point:
219-230°C
Boiling point:
645.7±55.0 °C(Predicted)
Density 
1.2
storage temp. 
-20°C
solubility 
DMSO: >10mg/mL
form 
solid
pka
4.78±0.70(Predicted)
color 
red
λmax
424nm(MeOH)(lit.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey
KQJSQWZMSAGSHN-JJWQIEBTSA-N
LogP
7.080 (est)
CAS DataBase Reference
34157-83-0(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45-24/25
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
2
RTECS 
YJ7900000
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C0869
Product name
Celastrol
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
219465
Product name
Celastrol
Packaging
10mg
Price
$245
Updated
2024/03/01
TCI Chemical
Product number
C2737
Product name
Celastrol
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$276
Updated
2024/03/01
Cayman Chemical
Product number
70950
Product name
Celastrol
Purity
≥98%
Packaging
5mg
Price
$76
Updated
2024/03/01
Cayman Chemical
Product number
70950
Product name
Celastrol
Purity
≥98%
Packaging
10mg
Price
$142
Updated
2024/03/01
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Celastrol Chemical Properties,Usage,Production

Pharmacological effects

  • Tripterine is a natural product with a variety of biological activity. It has a strong antioxidant effect, anti-cancer neovascularization effect as well as anti-rheumatoid effect. It is mainly isolated from the root bark of the celastraceae plant, Tripterygium wilfordii. It is one of the active ingredients contained in the rheumatoid-treatment drug Tripterygium tablet, Tripterygium Glycosides tablets and other preparations.
  • The major activity and pharmacological effects of Tripterine:
  • Cytotoxic activity. In vitro, it has non-specific cytotoxic activity against P388 and a group of human cancer cell lines.
  • Immune regulation. It could significantly inhibit the formation of hemolytic plaque cells in mouse spleen cells and significantly inhibit the mice delayed-type hypersensitivity.
  • Anti-inflammatory effect. At a dose of 0.5mg/kg, it could result in significant inhibition of the formation of rat cotton granuloma. At a dose of 0.1~1.0μg/mL, it could suppress the production of PGE2 induced by the yeast sugar; at a dose of 1.0μg/mL, it can inhibit the macrophage phagocytosis.
  • The anti-oxidation effect of tripterine is 15 times that of tocopherol with an IC50 of 7μM. Inhibit the peroxidation occurring inside and outside of the mitochondrial membrane, direct removing the free radicals.
  • Tripterine can extend the sleep time of mice triggered by the pentobarbital sodium.
  • Immunosuppressive effect: inhibit the spleen cell proliferation of mice induced by PHA, ConA and LPS, further inhibiting the lymphocyte proliferation.
  • It can inhibit the in vitro sperm fertilization capacity of guinea pig with the activity being significantly stronger than acetic acid gossypol.
  • Anti-arthritic effect, it will inhibit the activity of interleukin-1 of inside and outside the mouse intraperitoneal macrophages, inhibit the production of interleukin-2 by mouse spleen cells and lower the level of PGE2 produced by rabbit synovial cells.
Source: ChemicalBook Editorial.

Application

Celastrol is an effective proteasome inhibitor. It has been confirmed that it is capable of inducing apoptosis of cancer cells through inhibiting proteasome activity.

Description

Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM). ?It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin activity (IC50=2.5 mM). Induces autophagy by targeting AR/miR-101 in prostate cancer cells.4 Induces UPR-dependent cell death in cancer cells.5 Cell permeable.

Chemical Properties

Orange Red Solid

Uses

antineoplastic, NO synthesis inhibitor, chaperone stimulant

Uses

Celastrol is an antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. It is also a leptin sensitizer with the potential to reduce weight in obesity.

Uses

Celastrol can be used as an antioxidant onstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies.

Uses

An antioxidant natural product Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be

Definition

ChEBI: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. otently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF- α -induced NF κ B activation. Also shown to inhibit topoisomerase II activity in vitro (IC 50 = 7.41 μ M).

Biochem/physiol Actions

Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).

storage

+4°C

References

1) Sethi et al. (2007), Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κC-regulated gene products and TAK1-mediated NF-κB activation; Blood, 109 2727 2) Westerheide et al. (2004), Celastrols as inducers of the heat shock response and cytoprotection; J. Biol. Chem., 279 56053 3) Yang et al. (2006), Celastrol, a triterpene extracted from the Chinese “Thunder of God Vine” is a potent proteasome inhibitor and suppresses human prostate cancer cell growth in nude mice; Cancer Res., 66 4758 4) Guo et al. (2015), Celastrol Induces Autophagy by targeting AR/miR-101 in Prostate Cancer Cells; PLoS One, 10(10) e0140745 5) Fribley et al. (2015), Celastrol induces unfolded protein response-dependent cell death in head and neck cancer; Exp. Cell Res., 330 412

Celastrol Preparation Products And Raw materials

Raw materials

Preparation Products

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Celastrol Suppliers

Shanghai Moqi Biological Technology Co., LTD
Tel
021-38218169 13341702378
Email
190129269@qq.com
Country
China
ProdList
9042
Advantage
58
Guangzhou Shunyi Pharmaceutical Chemical Co., Ltd.
Tel
15360832999
Fax
QQ:1506687511
Email
jasontim@shuntongchem.cn
Country
China
ProdList
43
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Aktin Chemicals, Inc.
Tel
028-85159085
Email
info@aktinchem.com
Country
China
ProdList
1646
Advantage
58
Shanghai Jiaoze Industrial Co., LTD
Tel
021-37318802 18616909727
Fax
021-37318802
Email
liangpanpan@sh-jiaoze.com
Country
China
ProdList
107
Advantage
58
Shanxi Yuning Biotechnology Co., Ltd.
Tel
13623677056
Email
1639455302@qq.com
Country
China
ProdList
283
Advantage
58
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-85370565-229 18080489829
Email
3004654993@qq.com
Country
China
ProdList
9086
Advantage
60
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemvon Biotechnology Co., Ltd
Tel
021-50790412
Fax
+86-21-50790419
Email
info@chemvon.com
Country
China
ProdList
371
Advantage
57
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View Lastest Price from Celastrol manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
Celastrol 34157-83-0
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
≥98%HPLC
Supply Ability
20tons
Release date
2024-01-05
Changsha Staherb Natural Ingredients Co., Ltd.
Product
Celastrol; Bitter melon extract 34157-83-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥98% HPLC
Supply Ability
1000kg
Release date
2022-10-10
Changsha Staherb Natural Ingredients Co., Ltd.
Product
Celastrol; Common Threewingnut root extract 34157-83-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥98% HPLC
Supply Ability
1000kg
Release date
2022-10-10

34157-83-0, CelastrolRelated Search:


  • TRIPTERIN
  • (2r,4as,6as,6ar,14as,14br)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
  • 3-HYDROXY-9BETA,13ALPHA-DIMETHYL-2-OXO-24,25,26-TRINOROLEANA-1(10),3,5,7-TETRAEN-29-OIC ACID
  • 3-HYDROXY-24-NOR-2-OXO-1(10),3,5,7-FRIEDELATETRAEN-29-OIC ACID
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  • (9,13a,14,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic Acid
  • 3-Hydroxy-2-oxo- 24-nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic Acid
  • CELASTROL(SH)
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  • 2-Oxo-3-hydroxy-24-norfriedela-1(10),3,5,7-tetraene-29-oic acid
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  • Celastrol ,98%
  • (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
  • 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid
  • 3-Hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
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  • (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
  • (2r,4as,6as,6ar,14as,14br)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylicacid
  • (9,13a,14,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-
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  • C29H38O4
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