Desvenlafaxine succinate
- Product Name
- Desvenlafaxine succinate
- CAS No.
- 386750-22-7
- Chemical Name
- Desvenlafaxine succinate
- Synonyms
- Pristiq;Unii-zb22enf0xr;WY 45233 succinate;Desvenla succinate;Desvenlafaxine succinate;Norvenlafaxine succinate;Pristiq succinate hydrate;C16H25NO2.HOOCCH2CH2COOH.H2O;Desvenlafaxine (succinate hydrate);Desvenlafaxine succinate USP/EP/BP
- CBNumber
- CB01459766
- Molecular Formula
- C20H31NO6
- Formula Weight
- 381.47
- MOL File
- 386750-22-7.mol
Desvenlafaxine succinate Property
- storage temp.
- Store at +4°C
- solubility
- DMSO:3.0(Max Conc. mg/mL);7.51(Max Conc. mM)
- form
- Powder
- color
- White to off-white
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C16H25NO2.C4H6O4/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;5-3(6)1-2-4(7)8/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1-2H2,(H,5,6)(H,7,8)
- InChIKey
- ORUUBRMVQCKYHB-UHFFFAOYSA-N
- SMILES
- C(C(=O)O)CC(=O)O.C(C1C=CC(O)=CC=1)(C1(CCCCC1)O)CN(C)C
Safety
- HS Code
- 2922504500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29855
- Product name
- Desvenlafaxine (succinate hydrate)
- Packaging
- 50mg
- Price
- $84
- Updated
- 2024/03/01
- Product number
- 29855
- Product name
- Desvenlafaxine (succinate hydrate)
- Packaging
- 1g
- Price
- $765
- Updated
- 2024/03/01
- Product number
- 29855
- Product name
- Desvenlafaxine (succinate hydrate)
- Packaging
- 25mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 29855
- Product name
- Desvenlafaxine (succinate hydrate)
- Packaging
- 100mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- FD139136
- Product name
- 4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol succinate monohydrate
- Packaging
- 100mg
- Price
- $260
- Updated
- 2021/12/16
Desvenlafaxine succinate Chemical Properties,Usage,Production
Description
Desvenlafaxine Succinate is a dual serotonin and norepinephrine reuptake inhibitor (SNRI) that was approved for the treatment of major depressive disorder (MDD) in the United States in 2008. In order to improve the efficacy and safety profile of venlafaxine, Wyeth discovered and developed one of the major metabolites of venlafaxine, namely the O-desmethyl metabolite (desvenlafaxine). Desvenlafaxine is also being developed for the treatment of moderate to severe vasomotor symptoms associated with menopause (i.e., hot flashes and night sweats) and is also in phase III clinical trials to study it’s effectiveness in treating fibromyalgia and neuropathic pain.
Chemical Properties
Desvenlafaxine succinate (Pristiq SR) is an extended-release tablet for oral administration that contains desvenlafaxine succinate, a structurally novel SNRI for treating MDD. Desvenlafaxine succinate is a white to off-white powder that is soluble in water. The solubility of Desvenlafaxine succinate is pH-dependent. Its octanol: aqueous system (at pH 7.0) partition coefficient is 0.21. Desvenlafaxine succinate (Pristiq SR) is available as a 50 mg extended-release tablet for oral administration. The 50 mg tablet consists of light pink, square (pyramid, one-sided), film-coated tablets debossed “W” over “50” on the flat side.
Uses
Antianxiety therapeutic
Synthesis
Desvenlafaxine has been prepared via two different routes, and both are described in the scheme. The first route involved simple demethylation of venlafaxine (67) using L-selectride in dimethoxyethane giving desvenlafaxine 68 as its free base in 91% yield. Compound 68 was then recrystallized with succinic acid in acetone/ water to give desvenlafaxine succinate (VIII) in 86% yield. An alternative method to prepare desvenlafaxine is described in the bottom portion of the scheme. 4-Benzyloxyphenylacetic acid 69 was converted to its corresponding acid chloride upon treatment with thionyl chloride and catalytic DMF in refluxing methylene chloride. The crude reaction mixture was added to a solution of dimethylamine hydrochloride and triethyl amine in methylene chloride at 5 ??C to give dimethylacetamide 70 in 90% yield. Deprotonation of 70 with LHMDS in THF at -70 ??C followed by addition of cyclohexanone gave alcohol 71 in 82% yield. Reduction of the acetamide with borane THF complex in refluxing THF produced dimethyl amine 72 in 66% yield. Catalytic hydrogenation in the presence of 20% Pd/C effected debenzylation of 72 to give desvenlafaxine free base 68 in 87% yield.
Desvenlafaxine succinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Desvenlafaxine succinate manufacturers
- Product
- Desvenlafaxine Succinate 386750-22-7
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-09-06
- Product
- Desvenlafaxine succinate 386750-22-7
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2018-07-25