O-Desmethylvenlafaxine
- Product Name
- O-Desmethylvenlafaxine
- CAS No.
- 93413-62-8
- Chemical Name
- O-Desmethylvenlafaxine
- Synonyms
- DVS 233;Wy-45233;desvenlafaxine;Desvenlafaxine Base;Desmethylvenlafaxine;O-desMethylvenlafaxin;O-Desmethylvenlafaxine;Venlafxine-O-Desmethyl;Venlafaxine Impurity 36;Venlafaxine O-Desmethyl
- CBNumber
- CB8496834
- Molecular Formula
- C16H25NO2
- Formula Weight
- 263.38
- MOL File
- 93413-62-8.mol
O-Desmethylvenlafaxine Property
- Melting point:
- 208-213°C
- Boiling point:
- 403.8±25.0 °C(Predicted)
- Density
- 1.115±0.06 g/cm3(Predicted)
- Flash point:
- 9℃
- storage temp.
- 2-8°C
- solubility
- insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH
- pka
- 10.04±0.26(Predicted)
- InChIKey
- KYYIDSXMWOZKMP-UHFFFAOYSA-N
- LogP
- 0.33 at 25℃ and pH6
Safety
- Hazard Codes
- F,T,Xi
- Risk Statements
- 11-23/24/25-39/23/24/25-36
- Safety Statements
- 7-16-36/37-45-26
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 3
- RTECS
- GV8872620
- HS Code
- 29225090
- Hazardous Substances Data
- 93413-62-8(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- V-045
- Product name
- O-Desmethylvenlafaxine solution
- Purity
- 1.0?mg/mL in methanol, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $428
- Updated
- 2024/03/01
- Product number
- V-007
- Product name
- O-Desmethylvenlafaxine solution
- Purity
- 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $95.5
- Updated
- 2024/03/01
- Product number
- D5598
- Product name
- O-Desmethylvenlafaxine
- Packaging
- 1G
- Price
- $111
- Updated
- 2024/03/01
- Product number
- D5598
- Product name
- O-Desmethylvenlafaxine
- Packaging
- 5G
- Price
- $334
- Updated
- 2024/03/01
- Product number
- 9001881
- Product name
- (±)-O-Desmethyl Venlafaxine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2024/03/01
O-Desmethylvenlafaxine Chemical Properties,Usage,Production
Description
Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50＝47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.
Chemical Properties
White Solid
Originator
Wyeth (United States)
Uses
A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant
Uses
A metabolite of Venlafaxine (V120000), a selective serotonin noradrenaline reuptake inhibitor (SNRI). Used as an antidepressant.
Uses
a metabolite of Venlafaxine .;Labeled Venlafaxine, intended for use as an internal standard for the quantification of Venlafaxine by GC- or LC-mass spectrometry.
Definition
ChEBI: A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.
brand name
Pristiq
General Description
An analytical reference standard applicable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as urine drug testing, forensic analysis, or clinical toxicology. Also known as desvenlafaxine, O-desmethylvenlafaxine is an SNRI antidepressant marketed under the trade name Pristiq? for the treatment of depression. O-desmethylvenlafaxine is also a major urinary metabolite of venlafaxine, an SNRI antidepressant sold as Effexor? or Efexor and used to treat major depressive disorder, generalized anxiety disorder, and other anxiety disorders associated with depression.
Synthesis
Desvenlafaxine is chemically derived from 4-benzyloxyphenylacetic acid, by first converting to the acid chloride with oxalyl chloride and then condensing with dimethylamine to produce the corresponding N,N-dimethyl amide. Deprotonation of the amide with butyllithium, followed by condensation with cyclohexanone gives a b-hydroxyamide intermediate, which is reduced with alane, and debenzylated by using palladium on carbon and 1,4-cyclohexadiene to produce desvenlafaxine.
O-Desmethylvenlafaxine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from O-Desmethylvenlafaxine manufacturers
- Product
- O-Desmethylvenlafaxine 93413-62-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99% HPLC
- Supply Ability
- 2000tons
- Release date
- 2019-12-30
- Product
- O-Desmethylvenlafaxine 93413-62-8
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24