ChemicalBook > CAS DataBase List > Fluorexon

Fluorexon

Product Name
Fluorexon
CAS No.
1461-15-0
Chemical Name
Fluorexon
Synonyms
CALCEIN;CALCEINE;FLUOREXON;FLUREXONE;N,N'-[[3';FLUOREXONE;Oftasceine;oftasccine;Nsc 298193;CALCEIN(RG)
CBNumber
CB0146553
Molecular Formula
C30H26N2O13
Formula Weight
622.53
MOL File
1461-15-0.mol
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Fluorexon Property

Melting point:
200 °C
Boiling point:
662.7°C (rough estimate)
Density 
1.4388 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
H2O: soluble
form 
Powder
pka
6.67(at 25℃)
color 
Yellow-orange to orange-brown
PH Range
Weak green ' uorescence (6.0) to strong green ' uorescence (7.2)
Water Solubility 
insoluble
λmax
494nm
Stability:
Stable. Incompatible with strong oxidizing agents.
Biological Applications
Calcium indicator; fluoride indicator; iron indicator; mercury indicator; detecting nucleic acids,proteins; treating osteoporosis; drug delivery systems
Major Application
Chemical-mechanical polishing, stabilizing liposomes, cell motility assay, detecting nucleic acids, virus, screening safety of gastric mucosa, MDR inhibitors, delivery, imaging atherosclerotic plaque
CAS DataBase Reference
1461-15-0(CAS DataBase Reference)
EPA Substance Registry System
Glycine, N,N'-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-2',7'-diyl)bis(methylene)]bis[N-(carboxymethyl)- (1461-15-0)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-24/25-36/37/39-26
WGK Germany 
3
F 
10
HS Code 
32041900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1.02315
Product name
Calcein indicator
Purity
for metal determination
Packaging
5G
Price
$241
Updated
2024/03/01
Cayman Chemical
Product number
16221
Product name
Calcein
Packaging
1g
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16221
Product name
Calcein
Packaging
5g
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
16221
Product name
Calcein
Packaging
10g
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
16221
Product name
Calcein
Packaging
25g
Price
$169
Updated
2024/03/01
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Fluorexon Chemical Properties,Usage,Production

Chemical Properties

orange crystals

Uses

Calcein is used for determination of Ca in biological systems. Indicator for the fluorimetric determination of calcium in presence of Mg by complexometric titration.

Uses

Calcein could be useful for magnetic resonance imaging-guided sonodynamic and nitric oxide combination therapy.

Uses

Calcein is a anthene that is commonly used for the fluorometric determination of calcium in solution. As this form of calcein is not membrane permeable, it can be used in assays that evaluate membrane integrity. Calcein can also be used as a fluorescent indicator for fluoride, iron, and mercury. [Cayman Chemical]

Definition

ChEBI: Calcein is a xanthene dye. It has a role as a fluorochrome. It is functionally related to a fluoran.

Biological Activity

Calcein is a fluorescent dye and self-extinguishing probe that can be used as an indicator of lipid vesicle leakage, as well as a complex indicator for EDTA calcium titration and fluorescence determination of calcium.

Purification Methods

Dissolve it in distilled H2O and acidify with dilute HCl to pH 3.5. Filter off the solid acid and wash it well with H2O. Redissolve ca 10g in 300mL H2O containing 12g of NaOAc. Precipitate it again by adding HCl, filtering and washing with H2O. Add the solid to 200mL of EtOH stir for 1hour and filter. Repeat the EtOH wash and dry the bright yellow solid in a vacuum. This acid decomposes on heating at ca 180o. See below for the preparation of the Na salt. [Diehl & Ellingboe Anal Chem 28 882 1956]. Altenatively dissolve it in H2O and acidify with 3N HCl to pH 3.5. Collect the solid and wash it with H2O. The air-dried precipitate is extracted with 70% aqueous EtOH, filtered hot and cooled slowly. Fine yellow needles of the acid crystallise out; they are filtered off and dissolved in the minimum quantity of 0.01N NaOH and re-precipitated by adding N HCl to pH 3.5. It is then recrystallised from 70% aqueous EtOH (3x). The final product (acid) is dried at 80o in a vacuum for 24hours, m >300o(dec). It contains one molecule of water per molecule of acid (C30H36N4O13.H2O). The product is pure as revealed by electrophoresis at pH 5.6 and 8.6, and by TLC in i-BuOH/i-PrOH/AcOH/H2O (60:60:5:5 by volume) or i-PrOH or pH 8.0 borate buffer. [Wallach et al. Anal Chem 31 456 1959.] The Na salt is prepared by dissolving the pure acid in H2O containing 2 mols of NaOH per mol of acid reagent and lyophilising. It complexes with Ca and Mg ions. [Beilstein 19 III/IV 4338.]

Fluorexon Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fluorexon manufacturers

Hebei Duling International Trade Co. LTD
Product
Fluorexon 1461-15-0
Price
US $56.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 tons
Release date
2023-05-09
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Fluorexon 1461-15-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-08
Hebei Guanlang Biotechnology Co,.LTD
Product
Fluorexon 1461-15-0
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2023-05-31

1461-15-0, FluorexonRelated Search:

Hyaluronic acid Ethyl 2-(Chlorosulfonyl)acetate CARBOXYMETHYLCELLULOSE CALCIUM Fluorescein diacetate Calcitonin AZOMETHINE H Fluorescein LIGNOSULFONIC ACID, CALCIUM SALT Fluorescein Sodium Benzophenone imine CALCEIN-AM Folic acid Calcitonin salmon Citric acid Cellulose acetate Ascoric Acid CALCEIN DISODIUM SALT, INDICATOR FOR COM PLEXOMETRY FLUORESCEIN-BIS-METHYLIMINODIACETIC ACID (SODIUM)

  • BIS[N,N-BIS(CARBOXYMETHYL)AMINOMETHYL]FLUORESCEIN
  • CALCEIN
  • CALCEINE
  • CALCEIN, INDICATOR
  • FLUORESCEIN-2,7-BIS-METHYLIMINODIACETIC SODIUM SALT
  • FLUORESCEIN COMPLEXON
  • FLUORESCEIN COMPLEXONE
  • FLUORESCEIN-METHYLENE-IMINODIACETIC ACID
  • FLUOREXON
  • FLUOREXONE
  • FLUREXONE
  • LABOTEST-BB LT00159821
  • 2,7-BLS[BIS(CARBOXYMETHYL)AMINOMETHYL]-FLUORESCEIN
  • 3,3'-BIS[N,N-BIS(CARBOXYMETHYL)AMINOMETHYL]FLUORESCEIN
  • 3,6-DIHYDROXY-2,4-BIS-N,N'-DI-(CARBOXYMETHYL)-AMINOMETHYL FURAN
  • FLUOREXON, INDICATOR GRADE
  • CALCEIN INDICATOR FOR THE COMPLEXOMETRY
  • CalceineIndicatorGr
  • CalceineIndicatorGr(FluoresceinComplexone)
  • CalceineIndicatorGr-(FluoresceinComplexon)
  • FLUORESCEIN COMPLEXONE GR
  • Bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein~Fluorexon
  • Oftasceine
  • Glycine, N,N-(3,6-dihydroxy-3-oxospiroisobenzofuran-1(3H),9-9Hxanthene-2,7-diyl)bis(methylene)bisN-(carboxymethyl)-
  • CALCEIN(RG)
  • Fluorescein di-(methylimino diacetic acid)
  • Calcein(Fluorexone)
  • Calcein [for Fluorometric Determination of Ca]
  • Fluorescein-bis(methyliminodiacetic acid), Fluorexon, Bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein
  • Bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein, Calcein, Fluorescein Complexon
  • N,N'-[[3',6'-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-2',7'-diyl]bis(methylene)]bis[N-(carboxymethyl)glycine]
  • Calcein,Bis[N,Nbis(carboxymethyl)aminomethyl]fluorescein, Fluorescein-bis(methyliminodiacetic acid), Fluorexon
  • Calcein, indicator for metal titration
  • Bis-[di(carboxyMethylaMinoMethyl)]flurescein sodiuM salt
  • Fluorescein-2,7-bis-MethylaMinodiacetic acid sodiuM salt
  • CALCEIN HYDRATE: FOR FLUOROMETRIC DETERMINATION OF CA
  • CALCEIN INDICATOR FOR METAL DETERMINATIO
  • Calcein, AR
  • CALCEINCALCEINCALCEIN
  • 7’-diyl)bis(methylene)]bis[n-(carboxymethyl)--2
  • glycine,n,n’-[(3’,6’-dihydroxy-3-oxospiro[isobenzofuran-1(3h),9’-[9h]xanthene]
  • N,N’-[(3’,6’-dihydroxy-3-oxospiro(isobenzofuran-1(3H),9’-(9H)xanthene)-2’,7’-diyl)bis(methyGlycine
  • Fluorescein-bis(methyliminodiacetic acid)
  • N,N'-[[3'
  • oftasccine
  • 2,2',2'',2'''-(((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-2',7'-diyl)bis(Methylene))bis(azanetriyl))tetraacetic acid
  • Fluorescein, 2′,7′-bis[[bis(carboxymethyl)amino]methyl]-
  • Spiro[isobenzofuran-1(3h),9′-[9h]xanthene], glycine deriv.
  • 2,7-bis[n,n-bis(carboxymethyl)aminomethylene]- Uo-rescein
  • Acetic acid, [(3′,6′-dihydroxy-2′,7′- Uorandiyl)bis-(methylenenitrilo)]tetra-
  • Nsc 298193
  • Spiro[isobenzofuran-1(3h),9′-[9h]xanthene], glycine derivative
  • Fluorescein, 2 0 ,7 0 -bis[[bis(carboxymethyl) amino]methyl]-
  • Spiro[isobenzofuran-1(3 h ),9 0 -[9 h ]xanthene], Glycine derivative
  • Acetic Acid, [(3 0 ,6 0 -dihydroxy-2 0 ,7 0 -fluor- andiyl)bis(methylenenitrilo)]tetra-
  • Calcein indicator for metal determination
  • Calcein, Suitable for fluorometric determination of calcium and EDTA titration of calcium in the presence of magnesium.
  • 3,3'-Bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein (Calcein)