ChemicalBook > CAS DataBase List > Corynoxine B

Corynoxine B

Product Name: Corynoxine B
CAS No.: 17391-18-3
Chemical Name: Corynoxine B
Synonyms: Corynoxine B;Corynoxine B-RM;7-Isocorynoxine;Corynoxine B, 99.5%;(7R,16E)-17-Methoxy-2-oxo-20betaH-corynox-16-en-16-carbonsae;(E)-methyl 2-((1'R,6'S,7'S,8a'S)-6'-ethyl-2-oxo-3',5',6',7',8',8a'-hexahydro-2'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate;Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'R,6'S,7'S,8'aS)-
CBNumber: CB01469855
Molecular Formula: C22H28N2O4
Formula Weight: 384.48
MOL File: 17391-18-3.mol

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Corynoxine B Property

Boiling point:: 560.8±50.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 83.33 mg/mL (216.74 mM)
form: Solid
pka: 13.61±0.60(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 300110
Product name: Corynoxine B
Packaging: 10mg
Price: $581
Updated: 2021/12/16

Usbiological

Product number: 300111
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Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC145220
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Updated: 2021/12/16

AK Scientific

Product number: 5516CR
Product name: CorynoxineB
Packaging: 2mg
Price: $166
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC145220
Product name: Corynoxine B
Packaging: 5mg
Price: $171.25
Updated: 2021/12/16

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Corynoxine B Chemical Properties,Usage,Production

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the Rubiaceae plant Uncaria rhynchophylla.

Uses

Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer.

Definition

ChEBI: Corynoxine B is a member of indolizines. It has a role as a metabolite.

in vivo

Corynoxine B (5-20 mg/kg, i.p.) enhances autophagy of alpha synuclein (alpha syn) clearance in Parkinson's disease mice by targeting HMGB1/2^[3].

Animal Model:	A53T α-syn transgenic mouse model^[3].
Dosage:	5-20 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Promoted α-syn clearance

IC 50

α-synuclein Aggregation

Corynoxine B Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Corynoxine B manufacturers

Career Henan Chemical Co

Product: Corynoxine B 17391-18-3
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

17391-18-3, Corynoxine BRelated Search:

Butyl stearate geissoschizine methylether MITRAPHYLLINE corynoxeine Hirsutine Rhynchophylline UNCARINE D UNCARINE E Corynoxine UNCARINE C

Corynoxine B, 99.5%

Corynoxine B

7-Isocorynoxine

(7R,16E)-17-Methoxy-2-oxo-20betaH-corynox-16-en-16-carbonsae

Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'R,6'S,7'S,8'aS)-

Corynoxine B-RM

(E)-methyl 2-((1'R,6'S,7'S,8a'S)-6'-ethyl-2-oxo-3',5',6',7',8',8a'-hexahydro-2'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate

17391-18-3