Rhynchophylline

Product Name: Rhynchophylline
CAS No.: 76-66-4
Chemical Name: Rhynchophylline
Synonyms: NSC-21731;mitrinermin;MITRINERMINE;UNCARINE D(P);rhyncophylline;rhynchophyllin;RHYNCHOPHYLLINE;RHYNCHOLPHYLLINE;Hook vine extract;Rhynchophylline98%
CBNumber: CB0256535
Molecular Formula: C22H28N2O4
Formula Weight: 384.47
MOL File: 76-66-4.mol

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Rhynchophylline Property

Melting point:: 216°; mp 197-199° (Ban et al., loc. cit.)
alpha: D13 -14.7° (c = 2.5 in chloroform)
Boiling point:: 560.8±50.0 °C(Predicted)
Density: 1.23
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 6.4(at 25℃)
color: White to Off-White
λmax: 247nm(lit.)
Merck: 14,8197
Stability:: Hygroscopic
InChIKey: DAXYUDFNWXHGBE-QCJVZUPCSA-N
LogP: 3.311 (est)
CAS DataBase Reference: 76-66-4

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Safety

RTECS: GN1600000
HS Code: 29399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL80526
Product name: Rhynchophylline
Purity: phyproof<SUP>®</SUP> Reference Substance
Packaging: 10 mg
Price: $642
Updated: 2025/07/31

TRC

Product number: R414180
Product name: Rhynchophylline
Packaging: 100mg
Price: $315
Updated: 2021/12/16

Usbiological

Product number: 300890
Product name: Rhynchophylline
Packaging: 20mg
Price: $433
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FR42770
Product name: Rhynchophylline
Packaging: 25mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-3807
Product name: Rhynchophylline
Purity: 98.51%
Packaging: 5mg
Price: $96
Updated: 2021/12/16

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Rhynchophylline Chemical Properties,Usage,Production

Chemical Properties

Soluble in chloroform, acetone, ethanol, benzene, slightly soluble in ether and ethyl acetate, almost insoluble in petroleum ether. Derived from the hooked branches of Uncaria rhynchopylla (Miq.) Jacks.

Uses

Rhynchophylline is a novel erythropoietin-producing hepatocellular A4 (EphA4) inhibitor.

Definition

ChEBI: A natural product found in Uncaria macrophylla.

in vivo

Rhynchophylline (10 and 30 mg/kg, i.p., once daily for 4 days) protects rats from pMCAO surgery induced ischemic brain damage^[2].
Rhynchophylline (100 μM, 2 μL, injected bilaterally in the hippocamp) shows neuroprotective effects against Aβ1-42-induced neurotoxicity in rats^[5].
Rhynchophylline (50 mg/kg, p.o., daily, 3-4 weeks) inhibits EphA4 activation in the hippocampus of APP/PS1 mice^[6].

Animal Model:	Aβ1-42(1.6 μM, 2 μL) treated rats^[5]
Dosage:	100 μM, 2 μL
Administration:	injected bilaterally in the hippocamp
Result:	Rescued the soluble Aβ1-42-induced spatial learning and memory deficits. Inhibited Aβ1-42-induced excessive activation of extrasynaptic NMDARs.

References

See Rhyncophylline

Rhynchophylline Preparation Products And Raw materials

Raw materials

Preparation Products

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Rhynchophylline Suppliers

China 253 Germany 1 India 2 Japan 2 United Kingdom 3 United States 20 USA 1 Global 282

ShangHai YuanYe Biotechnology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Chembest Research Laboratories Limited

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TCI (Shanghai) Development Co., Ltd.

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Sichuan Kulinan Technology Co., Ltd

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View Lastest Price from Rhynchophylline manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: Rhynchophylline 76-66-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-25

Hebei Fengjia New Material Co., Ltd

Product: Rhynchophylline 76-66-4
Price: US $3.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100000
Release date: 2024-09-04

Hebei Chuanghai Biotechnology Co., Ltd

Product: Rhynchophylline 76-66-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-05

76-66-4, RhynchophyllineRelated Search:

Kresoxim-methyl Methylparaben Tribenuron methyl Basic Violet 1 Methyl acrylate Methanol Methyl salicylate Indole Methyl Isorhychophylline Hirsutine Diangoutengjian I Isocorynoxeine UNCARINE C SNAP-N-SHOOT 0.1mg/mL(P) corynoxeine UNCARINE D INDOLIZINE Anti-isorhynchophylline N-oxide

RHYNCHOLPHYLLINE

RHYNCHOPHYLLINE

MITRINERMINE

16e,20-alpha)-(7-bet

mitrinermin

Rhynchophylline 76-66-4

Hook vine extract

rhynchophyllin

UNCARINE D(P)

rhyncophylline

Methyl (E)-2-[(6'R,7'S)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate

Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid,6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-,methyl ester, (αE,1'R,6'R,7'S,8'aS)-

(7R,16E,20R)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester

NSC-21731

Rhynchophylline, 98%, from Uncaria rhynchophylla (Miq.) Miq. ex Havil.

Rhynchophylline &gt

Rhynchophylline USP/EP/BP

Rhynchophylline98%

methyl (E)-2-[(3R,6'R,7'S,8'aS)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate

Methyl (E)-2-((3R,6'R,7'S,8a'S)-6'-ethyl-2-oxo-2',3',6',7',8',8a'-hexahydro-5'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate

Rhynchophylline-RM

Rhynchophylline, 10 mM in DMSO

Rhynchophylline - Bio-X ?

76-66-4

C22H28N2O4

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Alkaloids

API