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2-Amino-3-bromo-5-cyanopyridine

Product Name
2-Amino-3-bromo-5-cyanopyridine
CAS No.
477871-32-2
Chemical Name
2-Amino-3-bromo-5-cyanopyridine
Synonyms
6-amino-6-bromonicotinonitrile;2-Amino-3-bromo-5-cyanopyridine;6-Amino-5-bromo-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 6-amino-5-bromo-;2-Amino-3-bromo-5-cyanopyridine ISO 9001：2015 REACH
CBNumber
CB01471094
Molecular Formula
C6H4BrN3
Formula Weight
198.02
MOL File
477871-32-2.mol
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2-Amino-3-bromo-5-cyanopyridine Property

Melting point:
194-195°
Boiling point:
294.4±40.0 °C(Predicted)
Density 
1.80±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
solid
pka
0.72±0.49(Predicted)
color 
Beige
InChI
InChI=1S/C6H4BrN3/c7-5-1-4(2-8)3-10-6(5)9/h1,3H,(H2,9,10)
InChIKey
CKUQTHSGTPGGFK-UHFFFAOYSA-N
SMILES
C1=NC(N)=C(Br)C=C1C#N
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Safety

TSCA 
N
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
A594680
Product name
6-Amino-5-bromonicotinonitrile
Packaging
500mg
Price
$150
Updated
2021/12/16
Matrix Scientific
Product number
043552
Product name
6-Amino-5-bromonicotinonitrile
Purity
>95%
Packaging
500mg
Price
$73
Updated
2021/12/16
Apolloscientific
Product number
OR2759
Product name
6-Amino-5-bromonicotinonitrile
Packaging
1g
Price
$95
Updated
2021/12/16
SynQuest Laboratories
Product number
3H37-9-Y0
Product name
6-Amino-5-bromonicotinonitrile
Packaging
1g
Price
$104
Updated
2021/12/16
Matrix Scientific
Product number
043552
Product name
6-Amino-5-bromonicotinonitrile
Purity
>95%
Packaging
1g
Price
$112
Updated
2021/12/16
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2-Amino-3-bromo-5-cyanopyridine Chemical Properties,Usage,Production

Synthesis

4214-73-7

477871-32-2

The general procedure for the synthesis of 6-amino-5-bromonicotinonitrile from 2-amino-5-cyanopyridine is as follows: Step 1: To a solution of 6-aminonicotinonitrile (102 mg, 0.86 mmol) in acetic acid (2 mL) was added a solution of bromine in acetic acid (0.86 mmol). The mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by rapid chromatography on silica gel (eluent: hexane/ethyl acetate, 3:1, v/v) to afford the title compound 6-amino-5-bromonicotinonitrile (110 mg, 65% yield). The product characterization data are as follows: 1H-NMR (DMSO, 300 MHz): δ 8.26 (d, 1H, J = 2.0 Hz), 8.10 (d, 1H, J = 2.0 Hz), 7.24 (bs, 2H). MS (APCI Neg): m/z 196, 198.

References

[1] Patent: WO2005/90337, 2005, A1. Location in patent: Page/Page column 42-43
[2] Patent: WO2008/60907, 2008, A2. Location in patent: Page/Page column 38
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 9, p. 2073 - 2078
[4] Patent: US2015/266872, 2015, A1. Location in patent: Paragraph 0783; 0784
[5] Patent: EP3372601, 2018, A1. Location in patent: Paragraph 0743; 0744

2-Amino-3-bromo-5-cyanopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-3-bromo-5-cyanopyridine Suppliers

China 74 Germany 1 India 3 United Kingdom 1 United States 9 Global 88
Changzhou Jienuo Pharmaceutical Technology Co., Ltd
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13915093723
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joinpharm@aliyun.com
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
96815
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
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China
ProdList
35896
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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42934
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Shanghai Sunway Pharmaceutical Technology Co., Ltd
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18270980682
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021 51613951
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mlcheng@sunwaypharm.cn
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China
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SuZhou ShiYa Biopharmaceuticals, Inc.
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86(512)5235 8471 17715136450
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86(512)5235 6881
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sales@shiyabiopharm.com
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China
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SynAsst Chemical.
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021-60343070
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021-35122006
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China
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Synchem OHG
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+49 5662 408730
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+49 5662 4087320
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info@synchem.de
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Germany
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HangZhou YuHao Chemical Technology Co., Ltd.
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0571-82693216
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0571-82880190
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info@yuhaochemical.com
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China
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2028
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58
Shanghai ChuangYan Chemical Technology Co., Ltd.
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021-11111111 11111111111
Fax
qq:546919421
Email
546919421@qq.com
Country
China
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3518
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View Lastest Price from 2-Amino-3-bromo-5-cyanopyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-3-bromo-5-cyanopyridine 477871-32-2
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Career Henan Chemical Co
Product
2-Amino-3-bromo-5-cyanopyridine 477871-32-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

477871-32-2, 2-Amino-3-bromo-5-cyanopyridineRelated Search:

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  • 477871-32-2