2-Amino-3-bromo-5-cyanopyridine
- Product Name
- 2-Amino-3-bromo-5-cyanopyridine
- CAS No.
- 477871-32-2
- Chemical Name
- 2-Amino-3-bromo-5-cyanopyridine
- Synonyms
- 6-amino-6-bromonicotinonitrile;2-Amino-3-bromo-5-cyanopyridine;6-Amino-5-bromo-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 6-amino-5-bromo-;2-Amino-3-bromo-5-cyanopyridine ISO 9001：2015 REACH
- CBNumber
- CB01471094
- Molecular Formula
- C6H4BrN3
- Formula Weight
- 198.02
- MOL File
- 477871-32-2.mol
2-Amino-3-bromo-5-cyanopyridine Property
- Melting point:
- 194-195°
- Boiling point:
- 294.4±40.0 °C(Predicted)
- Density
- 1.80±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 0.72±0.49(Predicted)
- color
- Beige
- InChI
- InChI=1S/C6H4BrN3/c7-5-1-4(2-8)3-10-6(5)9/h1,3H,(H2,9,10)
- InChIKey
- CKUQTHSGTPGGFK-UHFFFAOYSA-N
- SMILES
- C1=NC(N)=C(Br)C=C1C#N
Safety
- TSCA
- N
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A594680
- Product name
- 6-Amino-5-bromonicotinonitrile
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 3H37-9-Y0
- Product name
- 6-Amino-5-bromonicotinonitrile
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 043552
- Product name
- 6-Amino-5-bromonicotinonitrile
- Purity
- >95%
- Packaging
- 1g
- Price
- $112
- Updated
- 2021/12/16
- Product number
- 043552
- Product name
- 6-Amino-5-bromonicotinonitrile
- Purity
- >95%
- Packaging
- 500mg
- Price
- $73
- Updated
- 2021/12/16
- Product number
- OR2759
- Product name
- 6-Amino-5-bromonicotinonitrile
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
2-Amino-3-bromo-5-cyanopyridine Chemical Properties,Usage,Production
Synthesis
4214-73-7
477871-32-2
The general procedure for the synthesis of 6-amino-5-bromonicotinonitrile from 2-amino-5-cyanopyridine is as follows: Step 1: To a solution of 6-aminonicotinonitrile (102 mg, 0.86 mmol) in acetic acid (2 mL) was added a solution of bromine in acetic acid (0.86 mmol). The mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by rapid chromatography on silica gel (eluent: hexane/ethyl acetate, 3:1, v/v) to afford the title compound 6-amino-5-bromonicotinonitrile (110 mg, 65% yield). The product characterization data are as follows: 1H-NMR (DMSO, 300 MHz): δ 8.26 (d, 1H, J = 2.0 Hz), 8.10 (d, 1H, J = 2.0 Hz), 7.24 (bs, 2H). MS (APCI Neg): m/z 196, 198.
References
[1] Patent: WO2005/90337, 2005, A1. Location in patent: Page/Page column 42-43
[2] Patent: WO2008/60907, 2008, A2. Location in patent: Page/Page column 38
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 9, p. 2073 - 2078
[4] Patent: US2015/266872, 2015, A1. Location in patent: Paragraph 0783; 0784
[5] Patent: EP3372601, 2018, A1. Location in patent: Paragraph 0743; 0744
2-Amino-3-bromo-5-cyanopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-3-bromo-5-cyanopyridine Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 2-Amino-3-bromo-5-cyanopyridine manufacturers
- Product
- 2-Amino-3-bromo-5-cyanopyridine 477871-32-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 2-Amino-3-bromo-5-cyanopyridine 477871-32-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09