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2-CYANO-4-FLUOROBENZYL BROMIDE

Product Name
2-CYANO-4-FLUOROBENZYL BROMIDE
CAS No.
217661-27-3
Chemical Name
2-CYANO-4-FLUOROBENZYL BROMIDE
Synonyms
2-cyano-4-fluorobromobenzene;2-CYANO-4-FLUOROBENZYL BROMIDE;2-(broMoMethyl)-5-fluorobenzonitrile;Benzonitrile, 2-(bromomethyl)-5-fluoro-
CBNumber
CB01479232
Molecular Formula
C8H5BrFN
Formula Weight
214.03
MOL File
217661-27-3.mol
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2-CYANO-4-FLUOROBENZYL BROMIDE Property

Melting point:
64.9-65.9 °C
Boiling point:
263.6±25.0 °C(Predicted)
Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
liquid
color 
Colourless
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Safety

HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
B686113
Product name
2-(Bromomethyl)-5-fluorobenzonitrile
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
B686113
Product name
2-(Bromomethyl)-5-fluorobenzonitrile
Packaging
500mg
Price
$110
Updated
2021/12/16
Apolloscientific
Product number
PC500527
Product name
2-(Bromomethyl)-5-fluorobenzonitrile
Packaging
1g
Price
$51
Updated
2021/12/16
SynQuest Laboratories
Product number
3737-B-05
Product name
2-(Bromomethyl)-5-fluorobenzonitrile
Packaging
1g
Price
$56
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0070345
Product name
2-(BROMOMETHYL)-5-FLUOROBENZONITRILE
Purity
95.00%
Packaging
100MG
Price
$149.1
Updated
2021/12/16
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2-CYANO-4-FLUOROBENZYL BROMIDE Chemical Properties,Usage,Production

Synthesis

77532-79-7

217661-27-3

The general procedure for the synthesis of 2-(bromomethyl)-5-fluorobenzonitrile from 5-fluoro-2-methylbenzonitrile was as follows: first, 5-fluoro-2-methylbenzonitrile (28.51 g, 211 mmol), N-bromosuccinimide (NBS, 41.31 g, 232 mmol), and azobisisobutyronitrile (AIBN, 2.5 g, 15 mmol) were added to a carbon tetrachloride ( CCl4, 845 mL) in a mixture of nitrogen (N2) was passed for 10 min. Subsequently, the reaction mixture was heated to reflux for 8 hours. After completion of the reaction, the mixture was allowed to stand at room temperature overnight. On the following day, the reaction mixture was filtered and the filter cake was washed with carbon tetrachloride (500 mL). The filtrates were combined and the solvent was removed by evaporation to give a yellow oil. Finally, 2-(bromomethyl)-5-fluorobenzonitrile (29.74 g, 66% yield) was obtained as a light yellow oil using 5-25% ethyl acetate/hexane as eluent and purified by fast column chromatography on silica gel (SiO2). The structure of the product was confirmed by 1H NMR (500 MHz, CDCl3) with chemical shift δ: 7.55 (1H, dd, J = 8.6,5.2 Hz), 7.37 (1H, dd, J = 7.9,2.8 Hz), 7.32-7.28 (1H, m), 4.61 (2H, s).

References

[1] Patent: US2005/267105, 2005, A1. Location in patent: Page/Page column 63
[2] Patent: US2007/111984, 2007, A1. Location in patent: Page/Page column 29
[3] Patent: US2007/129379, 2007, A1. Location in patent: Page/Page column 22
[4] Patent: WO2007/64316, 2007, A1. Location in patent: Page/Page column 141
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 19, p. 3128 - 3144

2-CYANO-4-FLUOROBENZYL BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CYANO-4-FLUOROBENZYL BROMIDE Suppliers

China 44 India 1 United Kingdom 1 United States 6 Global 52
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
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58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Carbocore, Inc.
Tel
--
Fax
--
Email
sales@carbocore.com
Country
United States
ProdList
1436
Advantage
60

217661-27-3, 2-CYANO-4-FLUOROBENZYL BROMIDERelated Search:

3-Fluoro-2-(bromomethyl)benzonitrile 4-FLUORO-2-METHYLBENZYL BROMIDE 5-Fluoro-2-methylbenzonitrile 2-CYANO-4-FLUOROBENZYL BROMIDE 2-Cyanobenzyl bromide

  • 2-CYANO-4-FLUOROBENZYL BROMIDE
  • 2-(broMoMethyl)-5-fluorobenzonitrile
  • 2-cyano-4-fluorobromobenzene
  • Benzonitrile, 2-(bromomethyl)-5-fluoro-
  • 217661-27-3