6-Hydroxy-3-methylindazole

Product Name: 6-Hydroxy-3-methylindazole
CAS No.: 201286-99-9
Chemical Name: 6-Hydroxy-3-methylindazole
Synonyms: 3-Methylindazol-6-ol;6-Hydroxy-3-methylindazole;3-methyl-6-hydroxyindazole;1H-Indazol-6-ol, 3-methyl-;3-methyl-1,2-dihydroindazol-6-one
CBNumber: CB01481916
Molecular Formula: C8H8N2O
Formula Weight: 148.16
MOL File: 201286-99-9.mol

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6-Hydroxy-3-methylindazole Property

Boiling point:: 366.0±22.0 °C(Predicted)
Density: 1.349±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: 9.26±0.40(Predicted)
Appearance: Light brown to orange Solid
InChI: InChI=1S/C8H8N2O/c1-5-7-3-2-6(11)4-8(7)10-9-5/h2-4,11H,1H3,(H,9,10)
InChIKey: WTNPPQUZRFSUQF-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(O)=C2)C(C)=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H586990
Product name: 6-Hydroxy-3-methylindazole
Packaging: 100mg
Price: $65
Updated: 2021/12/16

TRC

Product number: H586990
Product name: 6-Hydroxy-3-methylindazole
Packaging: 500mg
Price: $265
Updated: 2021/12/16

Matrix Scientific

Product number: 072394
Product name: 6-Hydroxy-3-methylindazole
Purity: 95+%
Packaging: 250mg
Price: $324
Updated: 2021/12/16

Matrix Scientific

Product number: 072394
Product name: 6-Hydroxy-3-methylindazole
Purity: 95+%
Packaging: 1g
Price: $700
Updated: 2021/12/16

AK Scientific

Product number: W4256
Product name: 6-Hydroxy-3-methylindazole
Packaging: 5g
Price: $725
Updated: 2021/12/16

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6-Hydroxy-3-methylindazole Chemical Properties,Usage,Production

Synthesis

7746-29-4

201286-99-9

General procedure for the synthesis of 3-methyl-6-hydroxyindazole from 6-methoxy-3-methyl-1H-indazole: 6-methoxy-3-methyl-1H-indazole (620 mg, 3.82 mmol) was dissolved in dichloromethane (25 mL) and cooled to 0°C. Under stirring, a dichloromethane solution of boron tribromide (1 M, 17 mL) was slowly added. The ice bath was removed and the reaction mixture was allowed to gradually warm to room temperature and stirred overnight. Upon completion of the reaction, the reaction solution was quenched by slowly pouring it into a pre-cooled saturated aqueous sodium bicarbonate solution. The organic and aqueous phases were separated and the aqueous phase was extracted with ethyl acetate (3 x 25 mL). The organic phases were combined and concentrated to give the crude product. The crude product was purified by a Biotage fast chromatography system (40S silica gel column, eluent 45-60% acetone/heptane) to give 3-methyl-1H-indazol-6-ol (458 mg, 81% yield).

References

[1] Patent: WO2009/144554, 2009, A1. Location in patent: Page/Page column 50
[2] Patent: US6303600, 2001, B1
[3] Patent: WO2008/65508, 2008, A1

6-Hydroxy-3-methylindazole Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Hydroxy-3-methylindazole Suppliers

China 66 India 1 South Korea 1 United States 7 Global 75

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6-Hydroxy-3-methylindazole

3-Methylindazol-6-ol

3-methyl-1,2-dihydroindazol-6-one

1H-Indazol-6-ol, 3-methyl-

3-methyl-6-hydroxyindazole

201286-99-9