2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE

Uses

Product Name: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE
CAS No.: 846023-24-3
Chemical Name: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE
Synonyms: SKL780;Bosutinib Impurity 29;N-(2,4-Dichloro-5-methoxyphenyl)-2-cyanoacetamide;2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE;AcetaMide,2-cyano-N-(2,4-dichloro-5-Methoxyphenyl)-
CBNumber: CB01482463
Molecular Formula: C10H8Cl2N2O2
Formula Weight: 259.09
MOL File: 846023-24-3.mol

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2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE Property

Melting point:: 180-181 °C(Solv: ethyl acetate (141-78-6))
Boiling point:: 462.4±45.0 °C(Predicted)
Density: 1.436±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -1.71±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C10H8Cl2N2O2/c1-16-9-5-8(6(11)4-7(9)12)14-10(15)2-3-13/h4-5H,2H2,1H3,(H,14,15)
InChIKey: RPWHAQJEZWBZGX-UHFFFAOYSA-N
SMILES: C(NC1=CC(OC)=C(Cl)C=C1Cl)(=O)CC#N
CAS DataBase Reference: 846023-24-3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC149891
Product name: 2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide
Packaging: 50mg
Price: $62
Updated: 2021/12/16

AK Scientific

Product number: 3010AC
Product name: 2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide
Packaging: 250mg
Price: $74
Updated: 2021/12/16

AK Scientific

Product number: 3010AC
Product name: 2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide
Packaging: 1g
Price: $85
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC149891
Product name: 2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide
Packaging: 100mg
Price: $107
Updated: 2021/12/16

AK Scientific

Product number: 3010AC
Product name: 2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide
Packaging: 5g
Price: $139
Updated: 2021/12/16

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2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE Chemical Properties,Usage,Production

Uses

2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide (cas# 846023-24-3) is a useful research chemical.

Chemical Properties

Pale yellow powder

Synthesis

98446-49-2

372-09-8

846023-24-3

Example 4 Synthesis of 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide: 2,4-dichloro-5-methoxyaniline (5.00 g, 26 mmol) was mixed with cyanoacetic acid (2.28 g, 26.8 mmol) at 50 °C. Tetrahydrofuran was added to the mixture until complete dissolution. Subsequently, the solution was heated to reflux and 1,3-diisopropylcarbodiimide (4.2 mL, 26.8 mmol) was added slowly and dropwise. After 30 minutes of reaction, the reaction mixture was cooled to about 15 °C in an ice bath. The solid product formed was collected by filtration and washed with tetrahydrofuran. The filtrate was slowly poured into water and stirred for 30 minutes. The white solid product was collected by filtration again, washed with water and dissolved in 500 mL of ethyl acetate. The resulting solution was dried over anhydrous sodium sulfate and subsequently concentrated under vacuum to afford 5.9 g (88% yield) of the target compound 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide as a white solid with a melting point of 180-181 °C.1H NMR (400 MHz, DMSO-d6) δ 3.84 (s, 3H), 4.02 (s, 2H) 7.58 (s, 1H), 7.66 (s, 1H), 10.00 (s, 1H); mass spectra (electrospray ionization) m/z 257.0, 259.0 ([M-H]-). Elemental analysis (C10H8Cl2N2O2) calculated values: C, 46.36; H, 3.11; N, 10.81. measured values: C, 46.25; H, 3.10; N, 10.85.

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 26, p. 7868 - 7876
[2] Patent: US2005/43537, 2005, A1. Location in patent: Page/Page column 3; 6
[3] Patent: WO2006/47262, 2006, A1. Location in patent: Page/Page column 13-14
[4] Letters in Drug Design and Discovery, 2011, vol. 8, # 1, p. 9 - 13

2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE Suppliers

China 109 Germany 1 India 5 South Korea 1 United Kingdom 1 United States 5 Global 122

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View Lastest Price from 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE 846023-24-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Career Henan Chemical Co

Product: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE 864023-24-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-23

Career Henan Chemical Co

Product: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE 846023-24-3
Price: US $150.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2018-07-30

846023-24-3, 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDERelated Search:

Bosutinib Impurity 15 Bosutinib Impurity Deionized water 5-Amino-2,4-dichloroanisole 2-aMino-4-(3-chloropropoxy)-5-Methoxybenzoate 4-CHLORO-7-(3-CHLORO-PROPOXY)-6-METHOXY-QUINOLINE-3-CARBONITRILE Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate 7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE Bosutinib Bosutinib Monohydrate 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy- 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine N-(2,4-DICHLORO-5-HYDROXYPHENYL)ACETAMIDE 4-Methoxy-3-(3-(4-Methylpiperazin-1-yl)propoxy)aniline 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE Bosutinib Impurity 6

2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE

AcetaMide,2-cyano-N-(2,4-dichloro-5-Methoxyphenyl)-

Bosutinib Impurity 29

N-(2,4-Dichloro-5-methoxyphenyl)-2-cyanoacetamide

SKL780

846023-24-3

46023-24-3

864023-24-3