4-Amino-3-fluorophenylboronic acid, pinacol ester
- Product Name
- 4-Amino-3-fluorophenylboronic acid, pinacol ester
- CAS No.
- 819058-34-9
- Chemical Name
- 4-Amino-3-fluorophenylboronic acid, pinacol ester
- Synonyms
- 2-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline;2-fluoro-4-(4;3-Amino-5-pyridineboronic acid pinalcol ester;4-Amino-3-fluorophenylboronic acid, pinacol ester;4-AMino-3-fluorobenzeneboronic acid pinacol ester, 96%;4-Amino-3-fluorophenylboronic acid pinacol ester, 97%,;2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anil...;2-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzenaMine;2-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine;Benzenamine, 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber
- CB01486481
- Molecular Formula
- C12H17BFNO2
- Formula Weight
- 237.08
- MOL File
- 819058-34-9.mol
4-Amino-3-fluorophenylboronic acid, pinacol ester Property
- Melting point:
- 102-104°C
- Boiling point:
- 334℃
- Density
- 1.11
- Flash point:
- 156℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly)
- pka
- 2.84±0.10(Predicted)
- form
- Solid
- color
- Pale Orange to Light Brown
- Sensitive
- Air Sensitive
- InChIKey
- AIXGNRNTXUKZLC-UHFFFAOYSA-N
- CAS DataBase Reference
- 819058-34-9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- BML00187
- Product name
- 4-Amino-3-fluorophenylboronic acid pinacol ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- A633268
- Product name
- 4-Amino-3-fluorophenylboronic acid pinacol ester
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- A633268
- Product name
- 4-Amino-3-fluorophenylboronic acid pinacol ester
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- X2273
- Product name
- 4-Amino-3-fluorophenylboronic acid pinacol ester
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 076514
- Product name
- 4-Amino-3-fluorophenylboronic acid pinacol ester
- Purity
- 95+%
- Packaging
- 5g
- Price
- $899
- Updated
- 2021/12/16
4-Amino-3-fluorophenylboronic acid, pinacol ester Chemical Properties,Usage,Production
Synthesis
29632-74-4
73183-34-3
819058-34-9
General procedure for the synthesis of 4-amino-3-fluorophenylboronic acid pinacol ester from 2-fluoro-4-iodoaniline and bis(pinacolato) borate: 1. 2-Fluoro-4-iodoaniline (5.0 g, 21.1 mmol) and bis(pinacolato)ethylborane (5.89 g, 23.2 mmol) were dissolved in 130 mL of DMSO under argon protection. 2. Potassium acetate (6.21 g, 63.3 mmol) was added and argon was continuously passed for 10 minutes to exclude oxygen. 3. a 1:1 complex of [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (1.21 g, 1.50 mmol) with dichloromethane was added, and the reaction mixture was heated at 85 °C for 4.5 hours. 4. After the reaction was complete, it was cooled to room temperature and diluted with 500 mL of water. 5. The mixture was extracted with ethyl acetate (3 x 200 mL), the organic phases were combined, washed with water, dried over anhydrous sodium sulfate, and then concentrated to dryness under reduced pressure. 6. The crude product was purified by silica gel column chromatography with cyclohexane/ethyl acetate (90/10, v/v) as eluent. 7. 3.73 g of white powder was obtained in 75% yield. 8. The product had a melting point of 11.0%. 8. The melting point of the product was 112 °C. 9. 9. 1H NMR (400 MHz, CDCl3) data: δ (ppm): 1.2 (s, 12H); 3.8 (br s, 2H); 6.55 (t, 1H, J=7Hz); 7.25-7.35 (m, 2H).
References
[1] Patent: US2013/178472, 2013, A1. Location in patent: Paragraph 0239; 0240
[2] Patent: WO2008/32086, 2008, A1. Location in patent: Page/Page column 110
[3] Patent: WO2006/113432, 2006, A2. Location in patent: Page/Page column 66
[4] Patent: WO2008/32086, 2008, A1. Location in patent: Page/Page column 110
4-Amino-3-fluorophenylboronic acid, pinacol ester Preparation Products And Raw materials
Raw materials
Preparation Products
4-Amino-3-fluorophenylboronic acid, pinacol ester Suppliers
- Tel
- +1-2266000236
- sales@rdscientific.com
- Country
- Canada
- ProdList
- 1920
- Advantage
- 58
View Lastest Price from 4-Amino-3-fluorophenylboronic acid, pinacol ester manufacturers
- Product
- 4-Amino-3-fluorophenylboronic acid, pinacol ester 819058-34-9
- Price
- US $10.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-28
- Product
- 4-Amino-3-fluorophenylboronic acid, pinacol ester 819058-34-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25