ChemicalBook > CAS DataBase List > 4-Amino-3-fluorophenylboronic acid, pinacol ester

4-Amino-3-fluorophenylboronic acid, pinacol ester

Product Name
4-Amino-3-fluorophenylboronic acid, pinacol ester
CAS No.
819058-34-9
Chemical Name
4-Amino-3-fluorophenylboronic acid, pinacol ester
Synonyms
2-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline;2-fluoro-4-(4;3-Amino-5-pyridineboronic acid pinalcol ester;4-Amino-3-fluorophenylboronic acid, pinacol ester;4-AMino-3-fluorobenzeneboronic acid pinacol ester, 96%;4-Amino-3-fluorophenylboronic acid pinacol ester, 97%,;2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anil...;2-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzenaMine;2-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine;Benzenamine, 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber
CB01486481
Molecular Formula
C12H17BFNO2
Formula Weight
237.08
MOL File
819058-34-9.mol
More
Less

4-Amino-3-fluorophenylboronic acid, pinacol ester Property

Melting point:
102-104°C
Boiling point:
334℃
Density 
1.11
Flash point:
156℃
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly)
pka
2.84±0.10(Predicted)
form 
Solid
color 
Pale Orange to Light Brown
Sensitive 
Air Sensitive
InChIKey
AIXGNRNTXUKZLC-UHFFFAOYSA-N
CAS DataBase Reference
819058-34-9
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2931900090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BML00187
Product name
4-Amino-3-fluorophenylboronic acid pinacol ester
Purity
Aldrich
Packaging
1g
Price
$179
Updated
2025/07/31
TRC
Product number
A633268
Product name
4-Amino-3-fluorophenylboronic acid pinacol ester
Packaging
1g
Price
$120
Updated
2021/12/16
TRC
Product number
A633268
Product name
4-Amino-3-fluorophenylboronic acid pinacol ester
Packaging
250mg
Price
$55
Updated
2021/12/16
AK Scientific
Product number
X2273
Product name
4-Amino-3-fluorophenylboronic acid pinacol ester
Packaging
250mg
Price
$32
Updated
2021/12/16
Matrix Scientific
Product number
076514
Product name
4-Amino-3-fluorophenylboronic acid pinacol ester
Purity
95+%
Packaging
5g
Price
$899
Updated
2021/12/16
More
Less

4-Amino-3-fluorophenylboronic acid, pinacol ester Chemical Properties,Usage,Production

Synthesis

29632-74-4

73183-34-3

819058-34-9

General procedure for the synthesis of 4-amino-3-fluorophenylboronic acid pinacol ester from 2-fluoro-4-iodoaniline and bis(pinacolato) borate: 1. 2-Fluoro-4-iodoaniline (5.0 g, 21.1 mmol) and bis(pinacolato)ethylborane (5.89 g, 23.2 mmol) were dissolved in 130 mL of DMSO under argon protection. 2. Potassium acetate (6.21 g, 63.3 mmol) was added and argon was continuously passed for 10 minutes to exclude oxygen. 3. a 1:1 complex of [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (1.21 g, 1.50 mmol) with dichloromethane was added, and the reaction mixture was heated at 85 °C for 4.5 hours. 4. After the reaction was complete, it was cooled to room temperature and diluted with 500 mL of water. 5. The mixture was extracted with ethyl acetate (3 x 200 mL), the organic phases were combined, washed with water, dried over anhydrous sodium sulfate, and then concentrated to dryness under reduced pressure. 6. The crude product was purified by silica gel column chromatography with cyclohexane/ethyl acetate (90/10, v/v) as eluent. 7. 3.73 g of white powder was obtained in 75% yield. 8. The product had a melting point of 11.0%. 8. The melting point of the product was 112 °C. 9. 9. 1H NMR (400 MHz, CDCl3) data: δ (ppm): 1.2 (s, 12H); 3.8 (br s, 2H); 6.55 (t, 1H, J=7Hz); 7.25-7.35 (m, 2H).

References

[1] Patent: US2013/178472, 2013, A1. Location in patent: Paragraph 0239; 0240
[2] Patent: WO2008/32086, 2008, A1. Location in patent: Page/Page column 110
[3] Patent: WO2006/113432, 2006, A2. Location in patent: Page/Page column 66
[4] Patent: WO2008/32086, 2008, A1. Location in patent: Page/Page column 110

4-Amino-3-fluorophenylboronic acid, pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-Amino-3-fluorophenylboronic acid, pinacol ester Suppliers

Canada 1 China 112 India 5 United States 14 Global 132
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shanghai HuiKe Trading Co., Ltd.
Tel
15026939015
Fax
QQ：1498609168
Email
michael.liu16@yahoo.com
Country
China
ProdList
97
Advantage
52
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
Advantage
60
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
Advantage
55
AllyChem Co., Ltd.
Tel
0411-62313318 13942603642
Fax
0411-87549748
Email
info@allychem.com
Country
China
ProdList
1028
Advantage
65
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
Shanghai ShiXian Chemical Technology Co., Ltd.
Tel
18681884732
Fax
021-51632502
Email
2245256225@qq.com
Country
China
ProdList
1729
Advantage
50
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
ShangHai AmK Pharmaceutical Technology Co., Ltd.
Tel
微信 17321281695 18019252918
Fax
17321281695
Email
sale@amkchem.com
Country
China
ProdList
15136
Advantage
55
Shanghai Rong Lin Medical Technology Co., Ltd.
Tel
18602194589
Email
lincy-110@163.com
Country
China
ProdList
863
Advantage
58
Hangzhou Milestone Pharmtech Co., Ltd.
Tel
0571-82896630 18969958410
Email
sales_hz@milestonepharmtech.com
Country
China
ProdList
4895
Advantage
55
Suzhou Chenke Biotech Co., Ltd.
Tel
18662408853
Email
2120408911@qq.com
Country
China
ProdList
981
Advantage
55
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
Chengdu Research Accelerators Technology Co., Ltd.
Tel
028-64353063
Fax
028-64353063 QQ:784253935
Email
reacchemical@163.com
Country
China
ProdList
5253
Advantage
58
Wuhan Chemwish Technology Co.， Ltd
Tel
027-67849912
Fax
027-87531808
Email
sales@chemwish.com
Country
China
ProdList
9148
Advantage
60
AgileBioChem Co., Ltd.
Tel
18055517827
Email
sales@agilebiochem.com
Country
China
ProdList
1003
Advantage
50
Zhengzhou AnMusi Chemical Products Co., Ltd.
Tel
0371-55289822 18737195735
Fax
QQ：2370407954
Email
2370407954@qq.com
Country
China
ProdList
1981
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Civic Chemical Technology Co., Ltd.
Tel
021-34053660
Fax
QQ:2881074831
Email
sale2@labgogo.com
Country
China
ProdList
2018
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15814
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
9722
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Nanjing holy chemical co., LTD
Tel
19951936396
Email
1815156226@qq.com
Country
China
ProdList
2947
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shanghai Scochem Technology Co., Ltd.
Tel
021-33758897
Email
sales@scochem.com
Country
China
ProdList
1596
Advantage
58
Cool Pharm, Ltd
Tel
021-58581007 18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
12878
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2815688 13927872512
Fax
0751-8963795
Email
3007421951@qq.com
Country
China
ProdList
9939
Advantage
58
Shanghai Thunder Biological Technology Co., Ltd.
Tel
18621609968
Email
1162686636@qq.com
Country
China
ProdList
876
Advantage
58
Allfluoro pharmaceutical co. ltd.
Tel
+86-400-0216110 +86-15958047586
Fax
0086-21-33275002
Email
sales@allfluoro.com
Country
China
ProdList
11385
Advantage
58
Changzhou Fullone Chemical Co., Ltd.
Tel
+86-13328197671 +86-13861172460
Email
sales@borenchem.cn
Country
China
ProdList
1055
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22963
Advantage
58
Zhengzhou Edward Biology Co.,Ltd
Tel
0371-63682289 15538176268
Fax
QQ：1875164801
Email
jacschem@163.com
Country
China
ProdList
9926
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
Changzhou Yinghao Technology Development Co., Ltd
Tel
15151934985
Email
sales@yingsapharm.com
Country
China
ProdList
5181
Advantage
58
Wuhan Chemwish Technology Co., Ltd
Tel
027-67849912
Email
sales@chemwish.com
Country
CHINA
ProdList
10821
Advantage
58
Shanghai jingkang bioengineering co., ltd.
Tel
021-54721350 13524668266
Fax
021-5
Email
2881505714@qq.com
Country
China
ProdList
7872
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
More
Less

View Lastest Price from 4-Amino-3-fluorophenylboronic acid, pinacol ester manufacturers

Henan Fengda Chemical Co., Ltd
Product
4-Amino-3-fluorophenylboronic acid, pinacol ester 819058-34-9
Price
US $10.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-28
Career Henan Chemical Co
Product
4-Amino-3-fluorophenylboronic acid, pinacol ester 819058-34-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-25

819058-34-9, 4-Amino-3-fluorophenylboronic acid, pinacol esterRelated Search:

5-AMINO-2-FLUOROPHENYLBORONIC ACID Boric acid Sofalcone 4-Amino-2-fluorophenylboronic acid, pinacol ester 2-AMINO-5-FLUOROBENZENEBORONIC ACID 4-Amino-3-fluorophenylboronic acid, hydrochloride 3-Amino-4-fluorophenylboronic acid, pinacol ester 3-AMino-4-fluorophenylboronic acid 4-Fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline 3-Amino-5-fluorophenylboronic acid 5-Amino-2-fluorophenylboronic acid, HCl 2-Amino-5-fluorophenylboronic acid, HCl 3-Fluorophenylboronic acid 4-Amino-3-fluorophenylboronic acid, pinacol ester N-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 4-(Boc-aMino)-3-fluorobenzeneboronic acid pinacol ester 7-FLUORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)INDOLIN-2-ONE 1-[2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]-1H-PYRAZOLE

  • 4-Amino-3-fluorophenylboronic acid, pinacol ester
  • 4-AMino-3-fluorobenzeneboronic acid pinacol ester, 96%
  • 2-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzenaMine
  • 2-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine
  • 2-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline
  • 2-fluoro-4-(4
  • Benzenamine, 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anil...
  • 4-Amino-3-fluorophenylboronic acid pinacol ester, 97%,
  • 3-Amino-5-pyridineboronic acid pinalcol ester
  • 819058-34-9