TIN PROTOPORPHYRIN IX DICHLORIDE
- Product Name
- TIN PROTOPORPHYRIN IX DICHLORIDE
- CAS No.
- 14325-05-4
- Chemical Name
- TIN PROTOPORPHYRIN IX DICHLORIDE
- Synonyms
- SnPPIX;Nsc267099;TINPROTOPORPHYRIN;Tin protoporphyrin I;tin protoporphyrin IX;TIN PROTOPORPHYRIN IX DICHLORIDE;Tin Protoporphyrin IX (chloride);Tinprotoporphyrin IX,Tin protoporphyrin IX;Tin Protoporphyrin IX dichloride (NSC 267099;Stannate(2-) dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid]
- CBNumber
- CB0148951
- Molecular Formula
- C34H36Cl2N4O4Sn
- Formula Weight
- 754.29
- MOL File
- 14325-05-4.mol
TIN PROTOPORPHYRIN IX DICHLORIDE Property
- storage temp.
- Store at RT
- solubility
- Soluble to 25 mM in 1eq. NaOH and to 5 mM in DMSO
- form
- Dark red to violet solid.
- color
- Brown to reddish brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 16375
- Product name
- Tin Protoporphyrin IX (chloride)
- Packaging
- 5mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 16375
- Product name
- Tin Protoporphyrin IX (chloride)
- Packaging
- 10mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 16375
- Product name
- Tin Protoporphyrin IX (chloride)
- Packaging
- 25mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 16375
- Product name
- Tin Protoporphyrin IX (chloride)
- Packaging
- 50mg
- Price
- $380
- Updated
- 2024/03/01
- Product number
- 0747
- Product name
- TinprotoporphyrinIXdichloride
- Packaging
- 10
- Price
- $129
- Updated
- 2021/12/16
TIN PROTOPORPHYRIN IX DICHLORIDE Chemical Properties,Usage,Production
Uses
Tin Protoporphyrin IX Dichloride is a selective inhibitor of heme oxygenase.
Uses
Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin . While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses. TIN PROTOPORPHYRIN IX DICHLORIDE(SnPPIX) is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 μM). It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). SnPPIX prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally. It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen. SnPPIX is commonly used as a tool to study the role of HO-1 activity in cells and in animals.[Cayman Chemical]
in vivo
Tin protoporphyrin IX dichloride (intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment[1].
| Animal Model: | Male and female athymic nude mice with PDAC cell-derived xenograft tumors[1] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20 |
| Result: | Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine). |
TIN PROTOPORPHYRIN IX DICHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
TIN PROTOPORPHYRIN IX DICHLORIDE Suppliers
View Lastest Price from TIN PROTOPORPHYRIN IX DICHLORIDE manufacturers
- Product
- Tin-protoporphyrin IX 14325-05-4
- Price
- US $18.00-48.00/KG
- Min. Order
- 0.01KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-19