Protoporphyrin IX

Product Name: Protoporphyrin IX
CAS No.: 553-12-8
Chemical Name: Protoporphyrin IX
Synonyms: PPIX;PROTOPORPHYRIN;ZINC PROTOPORPHYRIN;ZINC PROTOPORPHYRIN-9;ZINC PROTOPORPHYRIN IX;2,18-Porphinedipropionic acid, 3,8,13,17-tetramethyl-7,12-divinyl-;ZNPP-9;185646;OOPORPHYRIN;PROTOPORPHYRIN-9
CBNumber: CB0723565
Molecular Formula: C34H34N4O4
Formula Weight: 562.66
MOL File: 553-12-8.mol

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Protoporphyrin IX Property

Melting point:: >300 °C(Solv: acetone (67-64-1))
Boiling point:: 629.06°C (rough estimate)
Density: 1.1829 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: 2-8°C
solubility: DMSO (Slightly)
form: Powder
color: purple
Water Solubility: 106.9mg/L(25 ºC)
Sensitive: light sensitive
Merck: 13,7990
BRN: 380795
Stability:: Light Sensitive
InChIKey: FEDYMSUPMFCVOD-UJJXFSCMSA-N
CAS DataBase Reference: 553-12-8
NIST Chemistry Reference: Protoporphyrin-1x(553-12-8)
EPA Substance Registry System: Protoporphyrin IX (553-12-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 8-10-23

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P8293
Product name: Protoporphyrin IX
Purity: ≥95%
Packaging: 1g
Price: $130
Updated: 2024/03/01

Strem Chemicals

Product number: 07-1820
Product name: Protoporphyrin IX
Packaging: 250mg
Price: $91
Updated: 2024/03/01

Strem Chemicals

Product number: 07-1820
Product name: Protoporphyrin IX
Packaging: 1g
Price: $267
Updated: 2024/03/01

Usbiological

Product number: 257164
Product name: Zinc protoporphyrin IX
Packaging: 10mg
Price: $375
Updated: 2021/12/16

TRC

Product number: P839138
Product name: Protoporphyrin-9
Packaging: 100mg
Price: $80
Updated: 2021/12/16

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Protoporphyrin IX Chemical Properties,Usage,Production

Uses

hepatoprotectant

Uses

Protoporphyrin IX has been used:

as a standard in protoporphyrin assays
in fluorescence spectra analysis
to treat cells in cell culture to study heme-mediated ferroportin 1 transcription

Definition

ChEBI: A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyri s.

General Description

Protoporphyrin IX belongs to the porphyrin family, which are a class of tetrapyrroles. It is the iron-free form of hemin and amphiphilic in nature. It is the precursor of heme in its biosynthetic pathway.

Biochem/physiol Actions

Protoporphyrin IX?levels are elevated in?tumor?cells due to?metabolism anomalies?compared to normal?cells.

Enzyme inhibitor

This iiron-free, immediate precusor of heme (FWfree-acid = 562.67 g/mol; CAS 553-12-8; brownish-yellow solid; soluble in a number of organic solvents; disodium and dipotassium salts solublized in the presence of Tween 80) has lmax values in 25% HCl are 602.4, 582.2, and 557.2 nm. Protoporphryrin IX is also an activator of guanylate cyclase. See also Iron Protoporphyrin IX; Heme; Hemin Target(s): aminolevulinate aminotransferase; 5-aminolevulinate synthase; glutamate: glyoxylate aminotransferase; glutathione S-transferase; glyoxalase I, or lactoylglutathione lyase; guanylate cyclase; heme oxygenase; hydroxymethylbilane synthase, or porphobilinogen deaminase; nitric-oxide synthase; porphobilinogen synthase, or 5-aminolevulinate dehydratase; succinyl-CoA synthetase; tryptophan pyrrolase, or tryptophan 2,3-dioxygenase; and uroporphyrinogen decarboxylase.

Purification Methods

Protoporphyrin IX (3,18-divinyl-2,7,13,17-tetramethylporphin-8,12-dipropionic acid, ooporphyrin) [553-12-8] M 562.7, pKEst ~ 4.8. Protoporphyrin IX is purified by dissolving (4g) in 98-100% HCOOH (85mL), diluting with dry Et2O (700mL) and keeping at 0o overnight. The precipitate is collected and washed with Et2O, then H2O, and dried in a vacuum at 50o over P2O5. It crystallises from aqueous pyridine and from Et2O in monoclinic, brownish-yellow prisms. The UV max values in 25% HCl are 557.2, 582.2 and 602.4nm. It is freely soluble in ethanolic HCl, AcOH, CHCl3, and Et2O containing AcOH. It forms sparingly soluble diNa and diK salts. [Ramsey Biochemical Preparations 3 39 1953, UV: Holden Aust J. Exptl Biol and Med Sci 15 412 1937, Garnick J Biol Chem 175 333 1948, IR: Falk & Willis Aust J Sci Res [A] 4 579 1951, Beilstein 26 IV 3042.]

Toxicity evaluation

protoporphyrin IX, is highly toxic in the presence of light and molecular oxygen, killing photosynthetic plants very quickly through the generation of singlet oxygen.

Protoporphyrin IX Preparation Products And Raw materials

Raw materials

Preparation Products

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Protoporphyrin IX Suppliers

China 171 Germany 3 India 3 Japan 1 Switzerland 3 United Kingdom 4 United States 22 Global 207

Shanghai Xianhui Pharmaceutical Co., Ltd.

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View Lastest Price from Protoporphyrin IX manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Protoporphyrin IX 553-12-8
Price: US $1.00-1.00/Kg/Bag
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-04-30

Hebei Yanxi Chemical Co., Ltd.

Product: Protoporphyrin IX 553-12-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-16

Hebei Yanxi Chemical Co., Ltd.

Product: Protoporphyrin IX 553-12-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-16

553-12-8, Protoporphyrin IXRelated Search:

VINYL PROPIONATE dimethyl protoporphyrin IX,Protoporphyrin IX dimethyl ester,PROTOPORPHYRIN IX DIMETHYL ESTER FROM*OX HEMIN 4-(4-CHLORO-BENZYLOXY)-PHENYLAMINE Folic acid Citric acid CHLORODIMETHYLVINYLSILANE Ethyl 2-(Chlorosulfonyl)acetate 2,2-Bis(hydroxymethyl)propionic acid PROTOPORPHYRINATO ZINC Hyaluronic acid SODIUM ORTHOSILICATE PROTAMINE SULFATE Protopine Protocatechuic acid Ascoric Acid 1,1,1-Trimethoxypentane Triethyl orthobutyrate TITANIUM ISOBUTOXIDE Protoporphyrin

KAMMERER'S PORPHYRIN

2,18-Porphinedipropionic acid, 3,8,13,17-tetramethyl-7,12-divinyl-

21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-

7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid

Kammerer's prophyrin

PROTOPORPHYRIN-'IX', FOR FLUORESCENCE

ProtoporphyrinIXforfluorescence95+%

PROTOPORPHYRINIX,FREEACID

Kammerers porphyrin, Ooporphyrin, 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid

18-porphinedipropionic acid

3,7,12,17-Tetramethyl-8,13-divinyl-2

3,3-(3,7,12,17-tetramethyl-8,13-divinylporphine-2,18-diyl)di(propionic acid)

ProtoporphyrinIXpurplepowder

OOPORPHYRIN

PROTOPORPHYRIN

PROTOPORPHYRIN-9

PROTOPORPHYRIN IX ZINC (II)

PROTOPORPHYRIN IX ZINC(II) COMPLEX

PROTOPORPHYRIN IX

PROTOPORPHYRIN-'IX'

(SP-4-2)-[7,12-DIETHENYL-3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPANOATO(4-)-N21,N22,N23,N24]-DIHYDROGEN ZINCATE(2-)

ZNPP-9

ZN(II) PROTOPORPHYRIN IX

ZINC(II) PROTOPORPHYRIN IX

ZINC PROTOPORPHYRIN

ZINC PROTOPORPHYRIN-9

ZINC PROTOPORPHYRIN IX

3,18-DIVINYL-2,7,13,17-TETRAMETHYLPORPHINE-8, 12-DIPROPIONIC ACID

3,7,12,17-TETRAMETHYL-8,13-DIVINYL-2,18-PORPHINE-DIPROPIONIC ACID

8,13-DIVINYL-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID ZINC DERIVATIVE

8,13-DIVINYL-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID

8,13-BIS(VINYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID

8,13-BIS(VINYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID ZINC(II)

7,12-DIETHENYL-3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID, ZINC COMPLEX

Protoporphyrin IX, ≥95%

3,3'-(3,8,13,17-tetramethyl-7,12-divinylporphyrin-2,18-diyl)dipropionic acid

185646

PPIX

Protoporphyrin IX USP/EP/BP

3,3'-(3,8,13,17-Ttramethyl-7,12-divinylporphyrin-2,18-diyl)dipropionic acid

rotoporphyrin IX

2H6]-Protoporphyrin IX

Protoporphyrin IX (6CI)

3,3'-(3,8,13,17-Tetramethyl-7,12-divinylporphyrin-2,18-diyl)dipropionic acid

553-12-8

15442-64-3

C34H34N4O4

Cell Signaling and Neuroscience

Cell Biology

Biochemicals and Reagents

BioChemical

Cyclic Nucleotide Metabolism

Detection

G Proteins and Cyclic Nucleotides

Guanylyl Cyclase Activators

Fluorescent Probes, Labels, Particles and Stains

Inhibitors

Natural Porphyrins and Derivitives