Protoporphyrin IX
- Product Name
- Protoporphyrin IX
- CAS No.
- 553-12-8
- Chemical Name
- Protoporphyrin IX
- Synonyms
- PPIX;PROTOPORPHYRIN;ZINC PROTOPORPHYRIN;ZINC PROTOPORPHYRIN-9;ZINC PROTOPORPHYRIN IX;2,18-Porphinedipropionic acid, 3,8,13,17-tetramethyl-7,12-divinyl-;ZNPP-9;185646;OOPORPHYRIN;PROTOPORPHYRIN-9
- CBNumber
- CB0723565
- Molecular Formula
- C34H34N4O4
- Formula Weight
- 562.66
- MOL File
- 553-12-8.mol
Protoporphyrin IX Property
- Melting point:
- >300 °C(Solv: acetone (67-64-1))
- Boiling point:
- 629.06°C (rough estimate)
- Density
- 1.1829 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly)
- form
- Powder
- color
- purple
- Water Solubility
- 106.9mg/L(25 ºC)
- Sensitive
- light sensitive
- Merck
- 13,7990
- BRN
- 380795
- Stability:
- Light Sensitive
- InChIKey
- FEDYMSUPMFCVOD-UJJXFSCMSA-N
- CAS DataBase Reference
- 553-12-8
- NIST Chemistry Reference
- Protoporphyrin-1x(553-12-8)
- EPA Substance Registry System
- Protoporphyrin IX (553-12-8)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P8293
- Product name
- Protoporphyrin IX
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 07-1820
- Product name
- Protoporphyrin IX
- Packaging
- 250mg
- Price
- $91
- Updated
- 2024/03/01
- Product number
- 07-1820
- Product name
- Protoporphyrin IX
- Packaging
- 1g
- Price
- $267
- Updated
- 2024/03/01
- Product number
- 257164
- Product name
- Zinc protoporphyrin IX
- Packaging
- 10mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- P839138
- Product name
- Protoporphyrin-9
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
Protoporphyrin IX Chemical Properties,Usage,Production
Uses
hepatoprotectant
Uses
Protoporphyrin IX has been used:
- as a standard in protoporphyrin assays
- in fluorescence spectra analysis
- to treat cells in cell culture to study heme-mediated ferroportin 1 transcription
Definition
ChEBI: A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyri s.
General Description
Protoporphyrin IX belongs to the porphyrin family, which are a class of tetrapyrroles. It is the iron-free form of hemin and amphiphilic in nature. It is the precursor of heme in its biosynthetic pathway.
Biochem/physiol Actions
Protoporphyrin IX?levels are elevated in?tumor?cells due to?metabolism anomalies?compared to normal?cells.
Enzyme inhibitor
This iiron-free, immediate precusor of heme (FWfree-acid = 562.67 g/mol; CAS 553-12-8; brownish-yellow solid; soluble in a number of organic solvents; disodium and dipotassium salts solublized in the presence of Tween 80) has lmax values in 25% HCl are 602.4, 582.2, and 557.2 nm. Protoporphryrin IX is also an activator of guanylate cyclase. See also Iron Protoporphyrin IX; Heme; Hemin Target(s): aminolevulinate aminotransferase; 5-aminolevulinate synthase; glutamate: glyoxylate aminotransferase; glutathione S-transferase; glyoxalase I, or lactoylglutathione lyase; guanylate cyclase; heme oxygenase; hydroxymethylbilane synthase, or porphobilinogen deaminase; nitric-oxide synthase; porphobilinogen synthase, or 5-aminolevulinate dehydratase; succinyl-CoA synthetase; tryptophan pyrrolase, or tryptophan 2,3-dioxygenase; and uroporphyrinogen decarboxylase.
Purification Methods
Protoporphyrin IX (3,18-divinyl-2,7,13,17-tetramethylporphin-8,12-dipropionic acid, ooporphyrin) [553-12-8] M 562.7, pKEst ~ 4.8. Protoporphyrin IX is purified by dissolving (4g) in 98-100% HCOOH (85mL), diluting with dry Et2O (700mL) and keeping at 0o overnight. The precipitate is collected and washed with Et2O, then H2O, and dried in a vacuum at 50o over P2O5. It crystallises from aqueous pyridine and from Et2O in monoclinic, brownish-yellow prisms. The UV max values in 25% HCl are 557.2, 582.2 and 602.4nm. It is freely soluble in ethanolic HCl, AcOH, CHCl3, and Et2O containing AcOH. It forms sparingly soluble diNa and diK salts. [Ramsey Biochemical Preparations 3 39 1953, UV: Holden Aust J. Exptl Biol and Med Sci 15 412 1937, Garnick J Biol Chem 175 333 1948, IR: Falk & Willis Aust J Sci Res [A] 4 579 1951, Beilstein 26 IV 3042.]
Toxicity evaluation
protoporphyrin IX, is highly toxic in the presence of light and molecular oxygen, killing photosynthetic plants very quickly through the generation of singlet oxygen.
Protoporphyrin IX Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Protoporphyrin IX manufacturers
- Product
- Protoporphyrin IX 553-12-8
- Price
- US $1.00-1.00/Kg/Bag
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-04-30
- Product
- Protoporphyrin IX 553-12-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-16
- Product
- Protoporphyrin IX 553-12-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-16