tert-Butyl N-[4-(aminomethyl)phenyl]carbamate

Product Name: tert-Butyl N-[4-(aminomethyl)phenyl]carbamate
CAS No.: 220298-96-4
Chemical Name: tert-Butyl N-[4-(aminomethyl)phenyl]carbamate
Synonyms: 4-(Boc-aMino)benzylaMine;4-(N-Boc-amino)benzylamine;4-AMinoMethyl-N-Boc-aniline;4-(Aminomethy)-1-N-Boc-aniline;4-(AMINOMETHYL)-1-N-BOC-ANILINE;2-(4-CHLOROPHENOXY)MALONDIALDEHYDE;4-Aminobenzylamine, 4-BOC protected;4-(TERT-BUTOXYCARBONYLAMINO)BENZYLAMINE;4-Aminobenzylamine, 4-BOC protected 95+%;TERT-BUTYL 4-(AMINOMETHYL)PHENYL CARBAMATE
CBNumber: CB0148986
Molecular Formula: C12H18N2O2
Formula Weight: 222.28
MOL File: 220298-96-4.mol

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tert-Butyl N-[4-(aminomethyl)phenyl]carbamate Property

Melting point:: 64-68 °C(lit.)
Boiling point:: 300.1±25.0 °C(Predicted)
Density: 1.120±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, protect from light, stored under nitrogen
form: solid
pka: 13.68±0.70(Predicted)
color: white
CAS DataBase Reference: 220298-96-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C,Xn
Risk Statements: 36/37/38-34-22-43
Safety Statements: 26-36-45-36/37/39-22-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 737283
Product name: 4-(Boc-amino)benzylamine
Purity: 95%
Packaging: 500mg
Price: $100
Updated: 2023/06/20

TRC

Product number: B603058
Product name: 4-(Boc-amino)benzylamine
Packaging: 5g
Price: $700
Updated: 2021/12/16

AK Scientific

Product number: V0510
Product name: 4-(Aminomethy)-1-N-Boc-aniline
Packaging: 10g
Price: $631
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0015475
Product name: (4-AMINO METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $679.37
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0015475
Product name: (4-AMINO METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 5G
Price: $1143.68
Updated: 2021/12/16

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tert-Butyl N-[4-(aminomethyl)phenyl]carbamate Chemical Properties,Usage,Production

Uses

4-(Boc-amino)benzylamine is used in preparation of degradation agents for Cyclin dependent kinase useful for the treatment of cancer.

Synthesis

143090-18-0

220298-96-4

General procedure for the synthesis of 4-aminomethyl-N-Boc-aniline from N-BOC-4-aminobenzonitrile: 4-(tert-butoxycarbonylamino)benzyl cyanide (1 g, 4.58 mmol) was dissolved in a solvent mixture of THF/isopropanol (1:1, 142 mL) and 10% Pd/C (Degussa type E101, 0.56 g, 0.26 mmol) was added . The reaction system was added via syringe under nitrogen protection. After purging the reaction mixture with nitrogen, it was hydrogenated overnight under 50 psi hydrogen pressure. Upon completion of the reaction, the catalyst was removed by Celite filtration. The filter cake was washed thoroughly with isopropanol (100 mL) and THF (100 mL). The filtrate was concentrated in vacuum and the resulting crude product was purified by silica gel column chromatography and separated using a methanol solution of DCM/2M ammonia (gradient elution procedure: 1:0 to 95:5 for 30 min; 95:5 for 3 min; 95:5 to 9:1 for 30 min; 9:1 for 30 min) to afford the target product, 4-aminomethyl-N-Boc-aniline (0.364 g, 36% yield) . Mass spectrum (ES-) m/z: 220.1 ([M-H]-).

References

[1] Patent: WO2007/28083, 2007, A2. Location in patent: Page/Page column 112

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl N-[4-(aminomethyl)phenyl]carbamate Suppliers

Belgium 1 Canada 1 China 98 France 1 Germany 3 Hungary 1 India 3 Ukraine 1 United Kingdom 9 United States 16 Global 134

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View Lastest Price from tert-Butyl N-[4-(aminomethyl)phenyl]carbamate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: tert-Butyl N-[4-(aminomethyl)phenyl]carbamate 220298-96-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-10

Career Henan Chemical Co

Product: tert-Butyl N-[4-(aminomethyl)phenyl]carbamate 220298-96-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

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220298-96-4