Garenoxacin
- Product Name
- Garenoxacin
- CAS No.
- 194804-75-6
- Chemical Name
- Garenoxacin
- Synonyms
- T 3811;T-3811;Aids080974;Aids-080974;Garenoxacin;Ganefloxacin;GARENOXACIN HBR;Garenoxacin USP/EP/BP;Garenoxacin (BMS-284756);223652-82-2 (Mesylate salt)
- CBNumber
- CB01504008
- Molecular Formula
- C23H20F2N2O4
- Formula Weight
- 426.41
- MOL File
- 194804-75-6.mol
Garenoxacin Property
- Melting point:
- 226-227°; mp 234-235°
- alpha
- D27 -9.0° (c = 0.10 in N,N-dimethylformamide)
- Boiling point:
- 581.5±50.0 °C(Predicted)
- Density
- 1.421±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMF (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 6.44±0.50(Predicted)
- color
- Off-White to Pale Yellow
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C23H20F2N2O4/c1-11-15-5-2-12(8-13(15)9-26-11)16-6-7-17-19(21(16)31-23(24)25)27(14-3-4-14)10-18(20(17)28)22(29)30/h2,5-8,10-11,14,23,26H,3-4,9H2,1H3,(H,29,30)/t11-/m1/s1
- InChIKey
- NJDRXTDGYFKORP-LLVKDONJSA-N
- SMILES
- N1(C2CC2)C2=C(C=CC(C3C=CC4=C(C=3)CN[C@@H]4C)=C2OC(F)F)C(=O)C(C(O)=O)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313IF exposed or concerned: Get medical advice/attention.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 278310
- Product name
- Garenoxacin
- Packaging
- 1mg
- Price
- $396
- Updated
- 2021/12/16
- Product number
- G245500
- Product name
- Garenoxacin
- Packaging
- 250mg
- Price
- $1455
- Updated
- 2021/12/16
- Product number
- 090188
- Product name
- (R)-1-Cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $691
- Updated
- 2021/12/16
- Product number
- API0013692
- Product name
- GARENOXACIN
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $700
- Updated
- 2021/12/16
- Product number
- 090188
- Product name
- (R)-1-Cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1623
- Updated
- 2021/12/16
Garenoxacin Chemical Properties,Usage,Production
Description
Garenoxacin is a new quinolone antimicrobial agent that exhibits a
broad spectrum of activity against both Gram-negative and Gram-positive
organisms, including the important community-acquired respiratory pathogens
S.pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. In addition, it has
potent activity against several resistant strains such as multidrug-resistant
S.pneumoniae, methicillin-resistant S.aureus (MRSA), and vancomycin-resistant
enterococci (VRE). It was launched in Japan as an oral treatment for respiratory tract and otorhinolaryngological infections. As with other quinolone antibiotics marketed in recent years, the mechanism of action of garenoxacin involves dual inhibition of two essential bacterial enzymes, DNA gyrase and topoisomerase IV. The lack of 6-fluoro substituent does not adversely affect its potency of inhibiting DNA gyrase (Escherichia coli, IC50 0.17 mg/mL) or topoisomerase IV (S. aureus, IC50 2.19 mg/ mL).
In human pharmacokinetic studies, oral garenoxacin results in dose-proportionate increases of plasma Cmax and AUC values at doses ranging from 50 to 1,200 mg. Its oral bioavailability is about 95%, and the mean terminal half-life is 15.4 h.
The most common adverse events associated with garenoxacin were rash, dizziness, nausea, headache, and pruritus. Garenoxacin is chemically derived in a sequence of 14 steps, 12 of which entail the construction of a key quinolone intermediate, 7-bromo-1- cyclopropyl-8-(difluoromethoxy)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester. Subsequently, Suzuki cross-coupling reaction of this intermediate with (R)-[1-methyl-2-(trityl)isoindolin-5-yl]boronic acid, followed by deprotection of the trityl group and ester hydrolysis with hydrochloric acid gives garenoxacin. The chiral isoindoline reagent is obtained from racemic 5-bromo-2-methylisoindoline via coupling with N-CBZ-L-phenylalanine, separation of diastereomers by chromatography, cleavage of the chiral auxiliary, N-tritylation, halogen-metal exchange with butyllithium, and boronation with triisopropyl borate.
Originator
Toyama (Japan)
Uses
Des-F(6)-quinolone antibacterial; topoisomerase II inhibitor. Antibacterial.
Definition
ChEBI: A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid that is substituted by a cyclopropyl group at position 1, an oxo group at position 4, a (1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl group at po ition 7, and a difluoromethoxy group at position 8.
brand name
Geninax
Garenoxacin Preparation Products And Raw materials
Raw materials
Preparation Products
Garenoxacin Suppliers
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- @pharmaffiliates.com
- Country
- India
- ProdList
- 6754
- Advantage
- 58
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- Country
- India
- ProdList
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View Lastest Price from Garenoxacin manufacturers
- Product
- Garenoxacin 194804-75-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98% HPLC
- Supply Ability
- 500 kgs
- Release date
- 2024-05-17
- Product
- Garenoxacin 194804-75-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- Garenoxacin 194804-75-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-20