ChemicalBook > CAS DataBase List > 2,4-Dichloro-6-methoxyquinazoline

2,4-Dichloro-6-methoxyquinazoline

Product Name: 2,4-Dichloro-6-methoxyquinazoline
CAS No.: 105763-77-7
Chemical Name: 2,4-Dichloro-6-methoxyquinazoline
Synonyms: 2,4-Dichloro-6-methoxyqui...;6-Methoxy-2,4-dichloroquinazoline;2,4-Dichloro-6-methoxyquinazoline;Quinazoline,2,4-dichloro-6-methoxy-
CBNumber: CB01504497
Molecular Formula: C9H6Cl2N2O
Formula Weight: 229.06
MOL File: 105763-77-7.mol

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2,4-Dichloro-6-methoxyquinazoline Property

Melting point:: 171 °C
Boiling point:: 315.9±24.0 °C(Predicted)
Density: 1.450
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.67±0.30(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C9H6Cl2N2O/c1-14-5-2-3-7-6(4-5)8(10)13-9(11)12-7/h2-4H,1H3
InChIKey: WEAMQTSRMCCGSJ-UHFFFAOYSA-N
SMILES: N1=C2C(C=C(OC)C=C2)=C(Cl)N=C1Cl

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN2811
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D438438
Product name: 2,4-Dichloro-6-methoxyquinazoline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: X8777
Product name: 2,4-Dichloro-6-methoxyquinazoline
Packaging: 1g
Price: $211
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-5-0V
Product name: 2,4-Dichloro-6-methoxyquinazoline
Packaging: 1g
Price: $525
Updated: 2021/12/16

Matrix Scientific

Product number: 057335
Product name: 2,4-Dichloro-6-methoxyquinazoline
Purity: 95%
Packaging: 1g
Price: $849
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0049826
Product name: 2,4-DICHLORO-6-METHOXYQUINAZOLINE
Purity: 95.00%
Packaging: 1G
Price: $1510.74
Updated: 2021/12/16

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2,4-Dichloro-6-methoxyquinazoline Chemical Properties,Usage,Production

Synthesis

32618-84-1

105763-77-7

Method F1: Synthesis of 2,4-dichloro-6-methoxyquinazoline (xa) To a mixture of 6-methoxyquinazoline-2,4(1H,3H)-dione (9.63 g, 50.2 mmol) and phosphorus trichloride (POCl3, 150 mL) was added N,N-dimethylaniline (0.5 mL). The reaction mixture was stirred at 120 °C for 2 hours. Upon completion of the reaction, the excess POCl3 was removed by distillation under reduced pressure. the residue was slowly poured into ice water and the pH was adjusted to about 7 by slowly adding saturated sodium bicarbonate (NaHCO3) solution at 0 °C, where a precipitate was formed. The precipitate was collected and dried under vacuum to give 2,4-dichloro-6-methoxyquinazoline (11.2 g, 98% yield) as a brown solid. LCMS m/z = 229.1, 231.0 [M + 1] (Method B) (retention time = 1.87 min). 1H-NMR (400 MHz, DMSO-d6): δ 7.89 (d, J = 9.2 Hz, 1H), 7.71 (dd, J = 8.8, 2.4 Hz, 1H), 7.38 (d, J = 1.6 Hz, 1H), 3.91 (s, 3H).

References

[1] Patent: US2015/307477, 2015, A1. Location in patent: Paragraph 1497
[2] Patent: JP6121658, 2017, B2. Location in patent: Paragraph 1096; 1099
[3] Patent: US2010/68197, 2010, A1. Location in patent: Page/Page column 17
[4] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 11, p. 2439 - 2444
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7717 - 7727

2,4-Dichloro-6-methoxyquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-Dichloro-6-methoxyquinazoline manufacturers

Career Henan Chemical Co

Product: 2,4-Dichloro-6-methoxyquinazoline 105763-77-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

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