citatuzumab

Product Name: citatuzumab
CAS No.: 896731-82-1
Chemical Name: citatuzumab
Synonyms: Conatumumab;citatuzumab;TRAIL-R2 mAb|||AMG 655;Research Grade Conatumumab;Research Grade Citatuzumab;Research Grade Conatumumab(DHA29103)
CBNumber: CB01518498
Formula Weight: 0
MOL File: Mol file

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citatuzumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0006504
Product name: CONATUMUMAB
Purity: 95.00%
Packaging: 5MG
Price: $499.07
Updated: 2021/12/16

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citatuzumab Chemical Properties,Usage,Production

Uses

Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. [1][2][3].

in vivo

Conatumumab (0-100 μg, i.p., twice weekly) inhibits tumor growth in mice bearing Colo205, H2122, or MiaPaCa2/T2 xenograft tumors^[2].
Conatumumab (2.5 μg, i.p., three times per week) enhances the antitumor activity of chemotherapeutics (CPT11, HY-16562) (80 mg/kg) in Colo 205 xenograft^[2].

Animal Model:	Mice bearing Colo205, H2122, or MiaPaCa2/T2 xenograft tumors^[2]
Dosage:	0, 0.1, 0.3, 1, 3, 10, 30, 100 μg
Administration:	Intraperitoneal injection (i.p.), twice weekly.
Result:	Dose-dependently inhibited tumor growth. Induced caspase-3 activation in tumors (determined by IHC).

References

[1] Herbst RS, et al. A first-in-human study of conatumumab in adult patients with advanced solid tumors. Clin Cancer Res. 2010 Dec 1;16(23):5883-91. DOI:10.1158/1078-0432.CCR-10-0631
[2] Kaplan-Lefko PJ, et al. Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types. Cancer Biol Ther. 2010 Apr 15;9(8):618-31. DOI:10.4161/cbt.9.8.11264

citatuzumab Preparation Products And Raw materials

Raw materials

Preparation Products

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citatuzumab Suppliers

China 21 United States 3 Global 24

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Guangzhou Hongyuan Chemical Co.,Ltd

Tel: 15817493340
Email: 981810490@qq.com
Country: China
ProdList: 1566
Advantage: 58

Wuhan Chemstan Biotechnology Co., Ltd.

Tel: 027-65317797 15926423062
Fax: QQ：422450190
Email: 422450190@qq.com
Country: China
ProdList: 10308
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Biolab Reagents

Tel: 027-65279366 18108604356
Email: products@biolabreagent.com
Country: China
ProdList: 9868
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Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 086-15871494362 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 6762
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Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

896731-82-1, citatuzumabRelated Search:

Blinatumomab Zolbetuximab Theralizumab Sirukumab Serclutamab Sacituzumab Pembrolizumab Vatelizumab Nurulimab Mirikizumab

citatuzumab

Conatumumab

Research Grade Conatumumab(DHA29103)

TRAIL-R2 mAb|||AMG 655

Research Grade Citatuzumab

Research Grade Conatumumab

896731-82-1